hrp0086p2-p526 | Fat Metabolism and Obesity P2 | ESPE2016

Prevalence of Overweight and Obesity in Children and Adolescents in Izmir, Western Turkey

Nalbantoglu Ozlem , Ozkan Behzat , Tunc Selma , Apa Hursit

Background: Although the highest prevelance rates of childhood obesity and overweihgt have been observed in developed countries, its prevelance is reported to be increasing in developing countries as well. Prevelance of obesity and overweight in different regions of Turkey ranges between 1.6–7.8 and 9.9–17.6 respectively.Objective and hypotheses: The purpose of this study was to investigate the prevelance of obesity and overweight among student...

hrp0089p2-p376 | Thyroid P2 | ESPE2018

Long Term Monitoring of Graves Disease in Children and Adolescents: Single Center Experience

Tunc Selma , Koprulu Ozge , Ortac Hatice , Nalbantoğlu Ozlem , Dizdarer Ceyhun , Demir Korcan , Ozkan Behzat

Introduction: Antithyroid Drugs (ATD) are generally preferred at the onset of treatment with no consensus on the duration of ATD (propylthiouracil, methymasole) treatment Graves disease in children.Objective: Examining the effectiveness of ATD treatment on children and adolescents and determining the risk factors of remission and relapse.Method: A total of 45 cases with ages varying between 1–18 years diagnosed with Graves dis...

hrp0086p1-p233 | Diabetes P1 | ESPE2016

Higher-Than-Conventional Subcutaneous Regular Insulin Doses Following Diabetic Ketoacidosis are Associated with Better Short-term Glycemic Control

Bag Ozlem , Tunc Selma , Nalbantoglu Ozlem , Ecevit Cigdem , Ozturk Aysel , Ozkan Behzat , Demir Korcan

Background: While some guidelines recommend 0.5–1.0 units/kg per day of subcutaneous insulin following resolution of diabetic ketoacidosis (DKA), up to 2 units/kg/day are used in various centers.Objective and hypotheses: To test the hypothesis that higher initial insulin doses would be more efficient during first 48 h of subcutaneous insulin therapy after DKA in cases with new-onset type 1 diabetes.Method: Records of patients ...

hrp0084p1-12 | Bone | ESPE2015

Genetic Diagnosis Using Whole Exome Analysis in Two Cases with Malign Infantile Osteopetrosis

Demir Korcan , Nalbantoglu Ozlem , Karaer Kadri , Korkmaz Huseyin Anil , Yildiz Melek , Tunc Selma , Ozkan Behzat

Aim: Osteopetrosis is caused by autosomal mutations occurring in nine genes (TNFRSF11A, TNFSF11, TCIRG1, CLCN7, OSTM1, SNX10, PLEKHM1, CA2, and LRP5). Detecting the aetiology and providing genetic counselling via individual mutation analysis of all these genes is expensive and time consuming. Whole exome sequencing is currently increasingly used given that the cost and the time needed are similar to that of single gene sequencing analysis. Here, two newborns,...

hrp0086p2-p493 | Fat Metabolism and Obesity P2 | ESPE2016

Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents

Tunc Selma , Demir Korcan , Tukun F Ajlan , Topal Cihan , Hazan Filiz , Saglam Burcu , Nalbantoglu Ozlem , Yildiz Melek , Ozkan Behzat

Background: Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity but there is no data for Turkish children.Objective: To determine the prevalence of MC4R mutations in a group of Turkish morbid obese children and adolescents.Method: MC4R gene was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1–18 years) who presented dur...

hrp0084p2-216 | Bone | ESPE2015

A Case with Acrodysostosis and Hormone Resistance

Tunc Selma , Demir Korcan , Hazan Filiz , Kirbiyik Ozgur , Soyaltin Eren , Nalbantoglu Ozlem , Yildiz Melek , Korkmaz Huseyin Anil , Ozkan Behzat

Aim: Acrodysostosis is a rare genetic syndrome characterized by small hands and feet with short, stubby fingers and toes, cone shaped epiphyses, broad nasal root, various abnormalities of mandible, skull, and vertebra, short stature, and mental retardation. Because of the hormone resistance that would accompany, acrodysostosis can be confused with pseudohypoparathyroidism. Mutations of PRKAR1A and PDE4D are reported to be responsible for the disease in less t...

hrp0084p2-541 | Puberty | ESPE2015

Distribution of Mutations in Genes Known to be Associated with Familial Idiopathic Hypogonadotropic Hypogonadism in a Large Cohort

Kotan L. Damla , Mengen Eda , Gurbuz Fatih , Ozsu Elif , Tunc Selma , Kor Yilmaz , Cakir Esra P. , Abaci Ayhan , Demir Korcan , Akcay Teoman , Kirel Birgul , Kinik Sibel T. , Ozen Samim , Ucakturk Ahmet , Bideci Aysun , Durmaz Erdem , Unluhizarci Kursad , Turan Ihsan , Yuksel Bilgin , Topaloglu A. Kemal

Background: Idiopathic hypogonadotropic hypogonadism (IHH) is characterised by failure of initiation or maintenance of puberty due to insufficient gonadotropin release, which is not associated with anosmia/hyposmia.Objective and hypotheses: The objective of this study was to determine the distribution of causative mutations in an hereditary form of IHH.Method: In this prospective collaborative study, families with more than one aff...