hrp0084p2-209 | Bone | ESPE2015

Sclerostin and Its Associations with Energy Metabolism in Children and Adolescents

Wedrychowicz Anna , Starzyk Jerzy

Background: The recent evidence has shown that the skeleton can in turn affect carbohydrate metabolism.Objective and hypotheses: To analyse associations between serum level of sclerostin and as well other bone-related molecules as adipokines and some markers of glucose and lipid metabolism in children and adolescents.Method: 57 patients, 40 with type 1 diabetes mellitus (T1DM), 17 with obesity, and 11 control, healthy age- and BMI-...

hrp0086p1-p367 | Gonads & DSD P1 | ESPE2016

Ovarian Reserve Assessment in Girls and Women after Hematopoietic Stem Cell Transplantation Treatment Underwent in Childhood

Wedrychowicz Anna , Wojtys Joanna , Starzyk Jerzy B.

Background: Hypogonadism is one of the most frequent endocrine complication after hematopoietic stem cell transplantation (HSCT). In some patients hypogonadism could be transient, but very often coexists with prematury ovarian failure. Classical methods used in the diagnostics of hypogonadism have limitations for the prognosis of ovarian reserve.Objective: The aim of the study was to assess ovarian reserve in patients after HSCT using ev...

hrp0082p2-d2-374 | Fat Metabolism & Obesity (1) | ESPE2014

The Role of Bone and Fat Tissue in Glucose Metabolism in Two Different Metabolic Conditions: Obesity and Diabetes Mellitus Type 1: Pilot Study

Wedrychowicz Anna , Sztefko Krystyna , Starzyk Jerzy

Background: Recent studies have shown a new link between skeleton, fat tissue, and insulin action. However, clinical data are still limited, especially in children.Objective: The aim of the presented study was to investigate the relationship between bone and fat hormones and glucose metabolism in children with type 1 diabetes mellitus (T1DM) and obesity.Methods: Forty-six T1DM children, mean age 12.2±4.6 years, mean BMI 20.0&#...

hrp0084p3-890 | Fat | ESPE2015

Does Vitamin D Influence Energy Metabolism in Children and Adolescents?

Wedrychowicz Anna , Sztefko Krystyna , Starzyk Jerzy

Background: Recent years bring a lot of data of the important role of vitamin D in different physiological processes, including a prevention from pathological states.Objective and hypotheses: The aim of the study was to analyze associations between serum level of vitamin D and some markers of glucose and lipid metabolism but also as well bone-related molecules as adipokines and in children and adolescents.Method: 57 patients, 40 wi...

hrp0089p3-p266 | Multisystem Endocrine Disorders P3 | ESPE2018

Assessment of Ovarian Reserve in Young Women with Hashimoto Disease – The Pilot Study

Wedrychowicz Anna , Wojtyś Joanna , Stelmach Malgorzata , Starzyk Jerzy B

Introduction: Human ovary is commonly the target of an autoimmune attack in cases of organ- or non-organ-specific autoimmune disorders. Hashimoto’s thyroiditis (HT) is likely to be associated with ovarian dysfunction and diminished ovarian reserve. The classical hormonal test assessing ovarian reserve as early follicular phase serum levels of FSH, inhibin B and estradiol (E2), which are interdependent, and the calculation of the number of antral follicles by transvaginal ...

hrp0086p1-p600 | Growth P1 | ESPE2016

The Influence of Recombinant Human Growth Hormone Treatment on Very Small Embryonic/Epiblast Like Stem Cells

Wedrychowicz Anna , Sielatycka Katarzyna , Kubis Ewa , Roztoczynska Dorota , Starzyk Jerzy B. , Ratajczak Mariusz Z.

Background: Present knowledge on the effects of growth hormone (GH) on aging and lifespan are controversial. Clinical data indicate that normal or high levels of GH may accelerate aging and increase the risk of cardio-vascular diseases. Very small embryonic-like stem cells (VSELs) are a population of developmentally early stem cells residing in adult tissues, which could have the potential role in aging and organ rejuvenation.Objective: The aim of the st...

hrp0082p3-d2-830 | Growth (1) | ESPE2014

Prader–Willi Syndrome and GH Therapy: valuable Effects and Adverse Events

Wilk Magdalena , Wzorek Katarzyna , Tobor Ewa , Dejniak Barbara , Wedrychowicz Anna , Dolezal-Oltarzewska Katarzyna , Zygmunt-Gorska Agata , Starzyk Jerzy

Background: Prader–Willi syndrome (PWS) is a genetic disorder with hypothalamic–pituitary dysfunction, in which obesity, excess fat to lean body mass cause metabolic complications. For the purpose of these disorders normalization, PWS patients have been treated with recombinant human GH (rhGH). Long-term tolerance in PWS children treated with rhGH is not well known and the data are still required.Objective and hypotheses: To evaluate effects of...

hrp0097p2-191 | Adrenals and HPA Axis | ESPE2023

Should we routinely assess hypothalamo-pituitary-adrenal axis in pediatric patients with Prader-Willi Syndrome?

Anna Wedrychowicz , Katarzyna Dolezal-Oltarzewska , Agata Zygmunt-Gorska , Anna Kalicka-Kasperczyk , Malgorzata Wojcik , Dominika Janus , Adrianna Kot , Agnieszka Lecka-Ambroziak , Elzbieta Petriczko , Joanna Wielopolska , Jerzy B Starzyk

Background: It was reported recently that central adrenal insufficiency (CAI) in pediatric patients (pts) with Prader-Willi Syndrome (PWS), presented in up to 60% of them, could be a potential cause of sudden death. Moreover it has been suggested that CAI could be aggravated by rhGH recombinant human growth hormone (rhGH) treatment.Objective: To prevent both over- and undertreatment with hydrocortisone, we assessed the p...