ESPE Abstracts

Background: Bronchiectasis is a result of recurrent pulmonary infections and chronic inflammation.Objective and hypotheses: Chronic inflammation may lead some endocrinological disorders. The consequences of the bronchiectasis on the endocrinological system and on the bone health in childhood were investigated in this study.Method: The medical records of the 64 children with bronchiectasis (32 females and 32 males) at the mean age o...

Background: Endothelial dysfunction underlies lung and other organ complications developing in associated with diabetes. Endothelial dysfunction leads to an increase in cytokine levels and oxidative stress. Studies have shown that the endothelin plays significant roles in the development of diabetic complications.Objective and hypotheses: The aim of this study is to show the effect of a new mechanism on endothelin receptors in the physiopathology of diab...

Background: No large study comparing efficiency of prednisolone, alendronate and pamidronate has been conducted so far in children with hypercalcemia due to vitamin D intoxication.Objective and hypotheses: To perform a multicentre, retrospective study assessing clinical characteristics and treatment results.Method: A standard questionnaire was uploaded to an online national database system (www.favorsci.org) to collect data of chil...

Background: Osteoporosis is very rare in childhood and main reasons are growth retardation, immobilisation, calcium and vitamin D deficiency, long term steroid therapy. There is no concensus about the treatment of children and adolescents with osteoporosis. Biphosphonates have been important in the treatment of osteoporosis.Objective and hypotheses: To evaluate the efficacy and safety of oral alendronate on bone mineral density (BMD) in children and adol...

Introduction: DKA is one of the most common pediatric emergencies. Hypertriglyceridemia and acute pancreatitis are infrequent complications of DKA. We present a 9-year-old female with new-onset DKA who presented with acute pancreatitis and hypertriglyceridemia and resolved on follow-up.Case presentation: A 9-year-old female, previously healthy, non-obese, presented to the hospital with breathing difficulty, abdominal pai...

Background: It has been reported that there is a relationship between circulating leptin and sex steroid hormones and leptin is able to stimulate estrogen secretion by increasing aromatase activity in adipose stromal cells and breast tissue. Leptin receptors have been also shown in mammary epitheleal cells and it has been suggested that leptin is involved in the control of the proliferation of both normal and malignant breast cells.Objective and hypothes...

Background: Thyroid nodules are rare in children compared to adults. Although most thyroid nodules are benign, the risk of malignancy is greater in pediatric patients.Case: We described a 10-year-old boy who presented with a right sided thyroid nodule that was 12×8 mm. He had not cervical lymphadenopathy. His fine needle aspiration biopsy cytology was benign. It was subsequently diagnosed as a Hurthle cell adenoma after thyroidectomy. In histopathol...

Objectives: We explored the alternative of using overnight fold change in gonadotropin levels by comparing the last-night-voided and first-morning-voided urine concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as a conceptual analogy to the invasive gonadotropin-releasing hormone (GnRH) stimulation test setting.Methods: We investigated the nocturnal changes in the immunoreactivity levels o...

Background: Adipose tissue acts as an endocrine organ, secreting biologically active molecules in response to external stimuli or lipid overloading. These adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin (4). On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between weight gain and serum...

Background: The exact mechanisms on growth are not fully eluciated, but they involve insulin resistance, fetal hyperleptinemia, hypothalamic changes. The adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin. On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between growth and serum insulin, ...