ESPE Abstracts

Results of epidemiological studies of 540 9–17 years old school children in Ternopil city are presented in this article. The aim is to determine the incidence of overweight, obesity, metabolic syndrome and hypertension among Ternopil schoolchildren and to trace clinical and phenotypic features of these pathological conditions among them. The results showed that the incidence of overweight among schoolchildren is 11.1% and obesity is 4.8% (11.8% of girls and 14.8% of boys)...

Introduction: Approximately 42 million children under the age of five are overweight or obese worldwide. Being overweight or obese at a young age is linked to several health and economic consequences and it is, therefore, important to study causes and risk factors and identify the best prevention and treatment strategies. The result of previous epidemiological study of 277 school boys in Ternopil city demonstrated that the prevalence of overweight and obesity among pupils are ...

Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disease characterised by neonatal/earlier-onset non-immune insulin –requiring diabetes associated with skeletal dysplasia and growth retardation. WRS is caused by mutations in the gene encoding eukaryoutic translation initiation factor 2 a kinase (EIF2AK3), which plays a key role in translation control during the unfolded protein response. In the endocrinological department of Ternopil Childrens’ Hospital ...

Introduction: The prevalence of obesity constantly increases worldwide and definitely increases the risk of premature death in early adulthood. Metabolic dysfunction-associated fatty liver disease (MAFLD) – a new term for fatty liver disease accompanied by other components of metabolic syndrome (MetS) connected with increase cardiovascular risk either in adult or children. Whereas there is no yet treatment with proven efficacy for the metabolic clamp suc...

Introduction: Thyroid disorders (such as endemic and nodular goiter, thyroiditis, congenital and acquired hypothyroidism) are one of the most common endocrine problems in children and adolescents in Ternopil Region (Ukraine) during the last decades. The main causes of goiter in children may include autoimmune diseases and iodine deficiency.Purpose: The aim of current study is to assess goiter according to etiology in the...

Background: Disorders of carbohydrate metabolism in children and adolescents with cystic fibrosis occur from 5 to 12.6%, significantly increasing during the teenage period and reaching 24–50% in adults.Method: An analysis of 499 medical records was conducted. All the patients were treated in the Russian Children’s Clinical Hospital in 2012. The survey was carried out on carbohydrate metabolism and indications according to children after 12 year...

Introduction: Diagnosing growth hormone deficiency (GHD) in children is complex. Spontaneous growth hormone (GH) pulses during late night may influence the pituitary GH response to provocation tests. We evaluated refractoriness during arginine-insulin-tolerance test (AITT) when having a GH-peak during a short spontaneous nocturnal profile in children with short stature.Methods: Altogether 257 children 0-18 years were exa...

Introduction: In the last years, the relationship between clinical markers and blood parameters has been evaluated closely as part of transversal studies, but a longitudinal approach might be more useful in explaining its complexity.Aim: The study aims to evaluate the relationship between changes in the values of clinical markers and of the inflammatory, biochemical and hormonal profiles of obese and overweight children ...

Background: Low stress resilience in late adolescence and psychosocial traumatic events in adulthood have been linked to a higher risk of developing type 2 diabetes (T2DM) later on in life. However, limited data is available regarding whether prior stressors are related to the risk of developing T2DM in adolescence.Objective: We sought to determine the potential association between prior toxic stressors and T2DM in adolescence.Desi...

Background: On reviewing practical aspects of intravenous bisphosphonate use in our tertiary Children’s Hospital, we noted disparity between departments who prescribed these drugs. This included issues pertinent to patient safety and hospital management, e.g. the need for overnight admission for the first infusion, blood tests and monitoring for adverse events (AEs). We therefore decided to survey the practices of other tertiary Paediatric Endocrinology Centres.<p cla...