hrp0098p3-326 | Late Breaking | ESPE2024

Effect of IM Depot Estradiol on Pubertal Progression and Uterine Development in Turner Girls

Anwar Ghada , Saber Rania , Maher Ghada , Mohammed Walaa , Antoune Marise

Introduction: Estrogen treatment is crucial for girls with TS to induce puberty. To mimic normal physical development, initiation of treatment should begin at 11–12 years of age if gonadotropins are elevated, or AMH is low. Different estrogen preparations can be used for this purpose, however only IM depot estradiol is available in Egypt.Aim: To evaluate progression of puberty and uterine development using IM depot...

hrp0089p2-p078 | Diabetes & Insulin P2 | ESPE2018

Protein and Fat Effects on Post - Prandial Glucose Responses among Egyptian Children and Adolescents with Type 1 Diabetes Mellitus

Arafa Noha , Hafez Mona , Anwar Ghada , Abdou Marise , Ibrahim Rania

Background: In the light of emerging recent researches and the use of continuous glucose monitoring it was shown that other nutritional properties of food, including fat, protein, and glycemic index (GI), can significantly affect postprandial glucose excursions. These findings highlight the need for alternative mealtime insulin dosing algorithms and have important implications for nutrition education and counseling in patients with diabetes.Objective and...

hrp0089p2-p031 | Adrenals and HPA Axis P2 | ESPE2018

The Relationship Between Vitamin D Status and Metabolic Abnormalities in Females with Classical Congenital Adrenal Hyperplasia: A Pilot Study

Hassan Mona , Ibrahim Amany , Abdou Marise , Atty Sahar Abdel , Nabil Diana

Congenital adrenal hyperplasia (CAH) patients have a higher frequency of obesity, visceral adiposity, hyperinsulinism, insulin resistance and hyperandrogenism. There is increasing evidence that low vitamin D status is associated with impaired β-cell function, insulin resistance and impaired glucose tolerance.Objectives: This pilot aimed to determine the status of serum 25 (OH) D levels in CAH female patients who are followed up in Diabetes Endocrine...

hrp0092p1-151 | Thyroid | ESPE2019

Iodine Status in Newborns and Mothers in Georgia

Patsatsia Ekaterine , Gordzeladze Marine

Background and Aims: For years Georgia belonged to a iodine deficiency endemic region, though as a result of a long-term actions aimed at improving the iodine status the country today is a non-iodine deficient region. For this reason it was decided to study present iodine status of newborns and their mothers leaving in the capital of Georgia, which is no longer non-iodine region.Materials and Methods: In total 87 newborn...

hrp0082p3-d1-711 | Diabetes | ESPE2014

Autoimmune Thyroiditis in Georgian Children and Adolescents with Type 1 Diabetes Mellitus

Abdushelishvili Nino , Gordeladze Marine

Background: Over the recent years there have been more and more cases with DM type 1 and thyroid autoimmune diseases.Objective: To study course of autoimmune thyroiditis in children and adolescents with DM type 1.Methods: From 758 children with DM type 1 we identified high risk cohort (thyroid gland palpation and clinical symptoms) and performed thyroid US and TSH, fT4, anti-TPO, anti-TG, and HbA1c testing. Cohort group,...

hrp0097fc5.6 | Diabetes and insulin 1 | ESPE2023

Post-Hypoglycemic Hyperglycemia Are Highly Relevant Markers For Stratification Of Glycemic Variability and Remission Status Of Pediatric Patients With New-Onset Type 1 Diabetes.

Harvengt Antoine , Pollé Olivier , Lysy Philippe

Aims: Recently, our team introduced the concept of post-hypoglycemic hyperglycemia (PHH) in the context that recovery of hypoglycemia impacts cardiovascular risk. GLUREDIA study aimed to evaluate whether PHH parameters correlated with glycemic homeostasis during the first year after type 1 diabetes onset and helped to distinguish pediatric patients undergoing partial remission or not.Methods: In the GLUREDIA study, longi...

hrp0095p2-55 | Diabetes and Insulin | ESPE2022

A case of de novo ABCC8 gene mutation resulting in Transient Neonatal Diabetes

Clemente Marisa Ferreira

Neonatal diabetes is characterised by hyperglycaemia in the first 6 months of life. Transient neonatal diabetes (TND) is differentiated from permanent neonatal diabetes by its remission in infancy/early childhood, with possible relapse during adolescence in 50% of the cases. Incidence of neonatal diabetes is thought to range from 1:90,000 to 1:160,000. A gene mutation affecting pancreatic beta cells synthesis/secretion of insulin is present in more than 80% of the cases. Overe...

hrp0098p2-79 | Diabetes and Insulin | ESPE2024

Linking diabetes and severe cardiac malformations: a GATA6 mutation

Clemente Marisa , Weerasinghe Kamal

Introduction: GATA6 is a gene that encodes a zinc transcription factor with a key role in the development of several organ systems, as evidenced by the many congenital malformations that have been associated with its mutation. GATA6 plays a role in gut, lung, pituitary, and heart development, with broad expression in developing heart tissue and close link with pancreatic agenesis/hypoplasia. Most cases present with neonatal Diabetes, but a small proportion dev...

hrp0098p3-259 | Thyroid | ESPE2024

Brain-Lung-Thyroid Syndrome: differences in clinical spectrum in two case reviews

Clemente Marisa , Weerasinghe Kamal

Introduction: Brain-lung-thyroid syndrome (BLTS) is a rare autosomal dominant or de novo condition that occurs in early childhood, associated with mutations of the NKX2-1 (Thyroid transcription factor 1) gene present in chromosome 14q13. This protein plays a critical role during organogenesis of basal ganglia, lungs, including surfactant production and homeostasis, and thyroid. The clinical spectrum varies from the complete triad of brain-lung-thyroid...

hrp0084p3-861 | Fat | ESPE2015

Decreased Insulin Sensitivity and Secretion in Obese Youth with High OGTT Derived 1 h Blood Glucose

Loredana M Loredana M , Marisi Elsa , Di Giovanni Ilaria , De Leonibus Chiara , Chiarelli Francesco , Mohn Angelika

Background: Obese adults with normal glucose tolerance (NGT) but 1-h post load glucose (1 hPG)≧155 mg/dl have an increased cardiometabolic risk. In children, preliminary data suggest that 1hPG≧132.5 mg/dl might identify those at higher risk of type 2 diabetes.Objective and hypotheses: To assess whether NGT obese youth with 1hPG ≧132.5 mg/dl (High-NGT) have worse insulin sensitivity and secretion compared to obese youth with 1hPG &#60...