hrp0098rfc14.2 | Fetal and Neonatal Endocrinology | ESPE2024

Does gestational diabetes mellitus influence mitochondrial dynamics in offspring?

Abali Saygin , Oz-Arslan Devrim , Guner-Yilmaz Bengisu , Celik Musa , Koç Berkcan , Muftuoglu Meltem , Pata Ozlem , Korkmaz-Toygar Ayse , Semiz Serap , Kan Beki , Beken Serdar

Introduction: Gestational diabetes mellitus (GDM) is a common problem in pregnancy with metabolic consequences for the fetus and the postnatal period. The aim of this study was to investigate the effects of GDM on mitochondrial structure and function in cord blood mononuclear cells and placental tissue, and the relationship between clinical data and mitochondrial dynamics.Method: In this prospective cohort study, singlet...

hrp0092p3-65 | Diabetes and Insulin | ESPE2019

Insulin-Induced Oedema in a Child with Newly Diagnosed Diabetes Mellitus

Cakir Meltem Didem , Baysal Ozlem

Oedema is a care complication of insulin therapy. It affects mainly patients with newly diagnosed type 1 diabetes mellitus, poorly controlled diabetes mellitus or patients on large doses of insulin. There are only a few case report showing that it is an uncommon and probably an under-reported complication. Two mecanisms are known: the sodium and water retention and vasoactive mediators release. The oedema tends to develop shortly after initiation of insulin therapy and resolve...

hrp0084p3-797 | DSD | ESPE2015

Screening for Y Microdeletions in Patients with Hypergonadotropic Hypogonadism due to Disorder of Sexual Development

Karaoglan Murat , Keskin Mehmet , Keskin Ozlem

Introduction: Hypergonadotropic hypogonadism is mainly characterised by streak or dysgenetic gonads. It is primer gonadal insufficiency which occurs as a result of chromosome abnormalities, gonad developmental and steroid synthesis defects. However, Y microdeletions associated hypergonadotropic hypogonadism due to disorder of sexual development has been reported, there are no many studies. Moreover, it is not known enough to contribution for development of sexual ambiquity. Ai...

hrp0089p3-p276 | Multisystem Endocrine Disorders P3 | ESPE2018

Autoimmunepolyendocrinopathy-Candidiasis-Ectodermal Dystrophy: A Case Report

Celik Tanju , Nalbantoglu Ozlem , Gursoy Semra , Sangun Ozlem , Arslan Gulcin , Ozkan Behzat

Introduction: Autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED) is a rare hereditary disorder with autoimmun manifestations affecting both endocrine and non-endocrine tissues. It is caused by mutations in the autoimmune regulatory (AIRE) gene which is defined by the presence of two of the three major components: Chronic mucocutaneous candidiasis, autoimmune hypoparathyroidism and Addison’s disease. Clinical manifestations may be developed during...

hrp0086p1-p233 | Diabetes P1 | ESPE2016

Higher-Than-Conventional Subcutaneous Regular Insulin Doses Following Diabetic Ketoacidosis are Associated with Better Short-term Glycemic Control

Bag Ozlem , Tunc Selma , Nalbantoglu Ozlem , Ecevit Cigdem , Ozturk Aysel , Ozkan Behzat , Demir Korcan

Background: While some guidelines recommend 0.5–1.0 units/kg per day of subcutaneous insulin following resolution of diabetic ketoacidosis (DKA), up to 2 units/kg/day are used in various centers.Objective and hypotheses: To test the hypothesis that higher initial insulin doses would be more efficient during first 48 h of subcutaneous insulin therapy after DKA in cases with new-onset type 1 diabetes.Method: Records of patients ...

hrp0086p2-p286 | Diabetes P2 | ESPE2016

Atypical Cystic Fibrosis Adolescent Case Study (with Normal Sweat Test) Referring with Diabetes Mellitus Symptoms Found to Carry Homozygous R352Q Mutation

Keskin Mehmet , Keskin Ozlem , Bilgic Eltan Sevgi , Fatih Deveci Mehmet

Background: Cystic fibrosis is an autosomal recessive genetic disorder affecting typically the lungs, the pancreas, the gastrointestinal tract and tissues that produce mucus secretion, such as sweat glands. Impaired glucose tolerance and cystic fibrosis-related diabetes are the most common complications of cystic fibrosis. Cystic fibrosis-related diabetes is another type of diabetes mellitus and carries some of the characteristics of type1 and type2 diabetes.<p class="abst...

hrp0086p2-p526 | Fat Metabolism and Obesity P2 | ESPE2016

Prevalence of Overweight and Obesity in Children and Adolescents in Izmir, Western Turkey

Nalbantoglu Ozlem , Ozkan Behzat , Tunc Selma , Apa Hursit

Background: Although the highest prevelance rates of childhood obesity and overweihgt have been observed in developed countries, its prevelance is reported to be increasing in developing countries as well. Prevelance of obesity and overweight in different regions of Turkey ranges between 1.6–7.8 and 9.9–17.6 respectively.Objective and hypotheses: The purpose of this study was to investigate the prevelance of obesity and overweight among student...

hrp0082p2-d3-489 | Endocrine Oncology | ESPE2014

Immunogenetics and Clinical Characteristics of Patients with the Most Common Organ-Specific Autoimmune Diseases: Evaluation in Respect of Gender and Autoimmunity

Karaoglan Murat , Keskin Mehmet , Keskin Ozlem , Ozturk Sibel

Background: Most of autoimmune disease such as type 1 diabetes (T1DM), autoimmune thyroiditis (AIT) and coeliac disease (CD) often coexist in the same patient. Although there are a lot of number of studies on autoimmunity against the thyroid glands and small bowel in patients with type 1 diabetes, little is known about pancreatic β-cell immunity in patients with AIT and CD.Objective and hypotheses: We studied autoimmune markers in children patients ...

hrp0082p3-d3-650 | Autoimmune Endocrine Disease | ESPE2014

Coexistence of Unusual and Distinctive İnitial Clinical Manifestations of Systemic Lupus Erythematosus (SLE): a Child Case Presentation and Evaluation of Polyglandular Autoimmune Syndrome in SLE

Karaoglan Murat , Keskin Mehmet , Ozturk Sibel , Kesin Ozlem

Background: Involvement of multiple spesific endocrine organs in systemic lupus erythematosus (SLE), as initial manifestations, are quite rare. These manifestations can appear singly or combined. But they have been usually reported singly. We report a child case who coexists many of rare clinical features of SLE at the same time at onset.Objective and hypotheses: Polyglanduler autoimmune syndrome may be a part of SLE. Coexistence of many polyglanduler au...

hrp0084p2-273 | Diabetes | ESPE2015

Utility of Estimated Glucose Disposal Rate and Fat Mass Percentage for Predicting Metabolic Syndrome in Children and Adolescents with Type 1 Diabetes

Koken Ozlem , Kara Cengiz , Yilmaz Gulay Can , Aydin Murat

Objective: To determine the prevalence of metabolic syndrome (MetS) and the clinical utility of fat mass percentage (%fat) and estimated glucose disposal rate (eGDR) for predicting MetS in children and adolescents with type 1 diabetes (T1D).Method: We conducted a descriptive, cross sectional study including T1D patients between 8–18 years of age. Modified criteria of IDF, WHO and NCEP were used to determine the prevalence of MetS. eGDR, a validated ...