hrp0095p2-121 | Fat, Metabolism and Obesity | ESPE2022

Age-related cardiometabolic risk in children and adolescents

Bizerea-Moga Teofana-Otilia , Loredana Pantea Cristina , Olah Orsolya , Marginean Otilia

Obesity, the silent pandemic of the 21st century, is being observed at increasingly younger ages. Included in the metabolic syndrome (MetS), it creates a favorable environment for the development of other components, such as impaired glucose tolerance (IGT), insulin resistance (IR), dyslipidemia (DysL) and arterial hypertension (HT). The aim of this study was to asses the influence of birth weight for gestational age (BW-GA) and age on the occurence of MetS and its components....

hrp0095p2-154 | GH and IGFs | ESPE2022

Predictive Factors of Adult Height After 2 Years of GH Replacement Therapy in Children with Growth Hormone Deficiency (GHD)

Mastromauro Concetta , Polidori Nella , Gentile Cristina , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: Growth Hormone Deficiency (GHD) represents the most common hormone deficiency during childhood accounting for 3% of causes of short stature. Although growth hormone (GH) replacement therapy is available, several studies have shown a different response in terms of height. Therefore, some reports have tried to characterize predictive factors able to define growth gain during treatment.Objective: Therefore, th...

hrp0095p2-274 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Congenital hypogonadotropic hypogonadism caused by a novel mutation of GnRHR gene: a case report

Cristina Maggio Maria , Venezia Renato , Maria Di Blasio Anna , Corsello Giovanni

Hypogonadotropic hypogonadism is characterized by low levels of gonadotropins and delayed or absent sexual development. Most of the patients reach the diagnosis in late adolescence or in adulthood. A timely, appropriate diagnosis implicates a better clinical outcome and treatment timing. We describe the clinical case of a 15-year-old girl with primary amenorrhea. Stature and weight were in accordance with mid parental height; Tanner stage: PH2 B1. FSH, LH, oestradiol showed pr...

hrp0092p1-95 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The role of Physical Activity on Postural Stability and Fitness Characteristics in Pediatric Patients with GH Deficiency

Brusa Jessica , Maggio Maria Cristina , Bellafiore Marianna , Corsello Giovanni , Palma Antonio , Messina Giuseppe

Purpose: Patients with growth hormone deficiency (GHD) show low fitness levels before GH treatment is started. Muscular strength, flexibility and postural stability are related to health and quality of life. Since it is widely recognized that physical activity increases GH secretion and GH could ameliorate fitness, if a high adherence to treatment is documented (1), the purpose of this study is to investigate any difference on posturographic parameters and mus...

hrp0092p1-192 | Fat, Metabolism and Obesity (1) | ESPE2019

Changes in Objectively Measured Sleep Quality After an Integral Intervention in Patients with Abdominal Obesity

Azcona Cristina , Catalán Ana , Morell Lydia , Ojeda Ana , Chueca María , Marti Amelia

Aim: to study sleep quality, using accelerometry in children and adolescents with abdominal obesity after a multidisciplinary intervention.Patients, Material and Methods: we included 122 children and adolescents, range age: 7 to 16 years old, diagnosed with abdominal obesity (waist circumference > p90) who participated in an 8-week intervention program to lose weight, with a 2-year follow-up period. Participants were...

hrp0092p1-202 | Fat, Metabolism and Obesity (1) | ESPE2019

Visceral Adiposity Index as a Marker of Metabolic Risk in Survivors of Paediatric Hematopoietic Stem Cell Transplantation After Chemotherapy-Only Conditioning

Cima Luminita-Nicoleta , Nedelea Lavinia , Soare Iulia , Barbu Carmen Gabriela , Zaharia Cristina , Colita Anca , Fica Simona

Background: Hematopoietic stem cell transplantation (HSCT) recipients exhibit excess adiposity that may result in an increased metabolic risk. Studies have shown that BMI is a poor predictor of body fatness in pediatric HSCT survivors population where diminished lean mass has been documented. The visceral adiposity index (VAI) has recently been proposed as a predictor of cardio-metabolic risk in both adults and children. However, the predictive value of this i...

hrp0092p1-392 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

Do Children and Adolescents with Idiopathic short Stature show Postural Alterations? Possible Influence of SHOX Haploinsufficiency in a Pilot Study

Maggio Maria Cristina , Messina Giuseppe , Brusa Jessica , Bellafiore Marianna , Corsello Giovanni , Palma Antonio

Purpose: Needs in terms of quality of life (QoL), consisting of physical, emotional and social domains, represent a hot spot in idiopathic short stature (ISS). Between ISS, it is estimated that 12% can have SHOX deficiency. Furthermore, SHOX deficiency can affect posture and GH treatment ameliorate their QoL. Although scientific research has investigated many fields of the physical domain, very few studies highlighted how this pathological condition may af...

hrp0092p2-160 | GH and IGFs | ESPE2019

Metabolic Outcome in Adolescents with Growth Hormone Deficiency During Transition Phase

Improda Nicola , Moracas Cristina , Paolo Ciccarelli Gian , Capalbo Donatella , Salerno Mariacarolina

Background: It is well known that GH deficiency (GHD) in adulthood is associated with detrimental cardiovascular (CV) effects. Although data are controversial, adolescents with childhood-onset GHD (COGHD) and reconfirmed GHD may have increased metabolic risk after GH treatment withdrawal at final height (FH).Aim: Aim of our study is to compare growth response and metabolic profile in idiopathic COGHD adolescents with rec...

hrp0092p3-120 | Fat, Metabolism and Obesity | ESPE2019

Toward a Simple Marker of Hepato-Visceral Adiposity and Insulin Resistance:The Z-Score Change from Weight-at-Birth to BMI-in-Childhood

Malpique Rita , de Zegher Francis , Garcia-Beltran Cristina , Ibáñez Lourdes

Insulin resistance and hepato-visceral (central) fat excess are thought to contribute to an earlier timing of adrenarche/pubarche and puberty/menarche; this earlier timing in turn relates often to a mismatch between pre- and postnatal weight gain, which can be estimated by calculating the Z-score change from birth weight (BW) to body mass index (BMI) in childhood. We tested the hypothesis that this calculation may serve as a proxy of insulin resistance and hepato-visceral adip...

hrp0092p3-144 | GH and IGFs | ESPE2019

A Case of Paediatric GH-secreting Pituitary Adenoma Apoplexy

Partenope Cristina , Gallo Dario , Pitea Marco , Pajno Roberta , Weber Giovanna , Barera Graziano , Cinzia Pozzobon Gabriella

Background: Paediatric pituitary adenomas comprise rare but challenging pathologies in children and adolescents related to their endocrine and neurological characteristics.Objective and Hypotheses: We aimed to describe a case report of growth hormone (GH)-secreting pituitary adenoma apoplexy.Method: a 11-year-old girl presented with fever, sudden headache with vomiting. She abruptl...