hrp0097p1-149 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Evaluation of new cutt-off points of the LHRH stimulation test in the diagnosis of central precocious puberty

Valls Llussà Aina , Murillo Vallés Marta , Martinez Couselo Silvia , Sol Ventura Paula

Introduction: Central precocious puberty (PPC) is defined by the appearance of sexual characters at a chronological age lower than -2.5DS of the average for the reference population. Diagnostic is clinical but the hormonal assessment is essential. Basal gonadotropin values are not enough for the diagnosis. Gonadotropin-releasing hormone (GnRH) stimulation tests evidence the activation of the hypothalamic-pituitary-gonadal axis, however there is controversy abo...

hrp0097p1-192 | Thyroid | ESPE2023

Remission in pediatric hyperthyroidism treated with methimazole

Ricci Jaime , Castro Bethania , Sabino Franco , Fasano Victoria , Tournier Andrea , Balbi Viviana , González Verónica , Morin Analía

Introduction: Hyperthyroidism (HT) is a condition characterized by inappropriately high thyroid hormone (TH) activity at receptor level, due to high synthesis and secretion of TH by thyroid gland. Antithyroid drugs as methimazole (MMI) are used as the first-line therapy in children. However, the optimal treatment duration and the predictive remission factors are still controversial.Objective: To investigate outcome of MM...

hrp0097p1-583 | Thyroid | ESPE2023

Was newborn screening for congenital hypothyroidism affected by COVID19 lockdown?

Vitale Laura , Esposito Mariela , Francesca Jesica , Victoria Fasano María , Balbi Viviana , Tournier Andrea , Borrajo Gustavo , González Verónica , Morín Analía

Mandatory lockdown during COVID 19 pandemic obstaculized access to medical attention. Newborn screening (NBS) for congenital hypothyroidism (CH) in Buenos Aires province has been obligatory since 1995 and performed sustainedly. CH causes mental delay if not diagnosed and treated early.Objectives: The aim of this study was to determine if mandatory lockdown changed time of established NBS diagnosis steps.Mat...

hrp0097p2-19 | Growth and Syndromes | ESPE2023

Gonadotropin and Estradiol levels in Turner Syndrome: does an old dog teach new tricks?

Casalini Emilio , Fava Daniela , Alessia Angelelli , Patti Giuseppa , Napoli Flavia , Elsa Maria Allegri Anna , Gastaldi Roberto , Tedesco Caterina , Passarella Tommaso , Pistorio Angela , Maghnie Mohamad , Di Iorgi Natascia

Background: Hypergonadotropic hypogonadism (HH) is an hallmark of Turner Syndrome (TS) and hormone replacement therapy (HRT) is often required for pubertal induction; this retrospective study highlights the pituitary-gonadal axis during infancy (<5 years), childhood (5–10.9 years) and adolescence (> 11 years) in a cohort of TS patients enrolled between February 1999 to March 2023. Our aim is to underline the diagnostic role of Gonadotropins as a ma...

hrp0098fc8.6 | Adrenals and HPA Axis 2 | ESPE2024

Plasma concentrations of renin and ACTH in children and adolescents from the general population: new reference intervals according to sex, age, and pubertal stage

Edström ernille , A. Holmboe Stine , Vilmann Lea , R. Grøndahl Veronica , E. Thomsen Charlotte , Ø. Fritzbøger Andrés , Aksglaede Lise , P. Hagen Casper , H. Petersen Jørgen , R. Jørgensen Niklas , Juul Anders , Holm Johannsen Trine

Introduction: Management of children with adrenal disorders such as congenital adrenal hyperplasia involves thorough clinical monitoring, including measurements of plasma renin concentrations (PRC) and ACTH. However, sex- and age-related reference intervals (RIs) for PRC and ACTH using novel immunoassays are needed.Aim: To evaluate circulating concentrations of renin and ACTH in children and adolescents from the general ...

hrp0098fc9.4 | Sex Endocrinology and Gonads | ESPE2024

Prenatal exposure to paracetamol is associated with smaller testis volume and decreased levels of steroid metabolites during infancy in healthy males: A COPANA cohort study of 287 boys

Mola Gylli , Bistrup Fischer Margit , Frederiksen Hanne , Scheel Lone , Bak Wraae Katrine , Lilleøre Rom Ane , Kristine Hegaard Hanne , Møbjerg Kristensen David , Juul Anders , Hagen Casper

Background: Paracetamol is bought over the counter and frequently used by pregnant women. Studies suggest that paracetamol is endocrine-disruptive, affecting for example germ cell proliferation. Fetal male masculinization is initiated in early gestation (GW 8-14).Primary aim: To assess if prenatal exposure to paracetamol was associated with testicular function.Design: Prospective, ...

hrp0098rfc7.1 | GH and IGFs | ESPE2024

Understanding the molecular basis of short stature in Fanconi Anemia: Impact of pappalysins and stanniocalcins on IGF-I bioavailability

Corredor Beatriz , Martín Alvaro , Zubicaray Josune , Sevilla Julián , Barrios Vicente , Argente Jesús

Introduction: The stanniocalcins (STCs) are inhibitory factors of the growth-promoting effects of IGFs through inactivation of pappalysins that favor the release of IGFs from their binding proteins (IGFBPs). STC1 can be involved in the cellular response to stress and plays an important role in cell cycle regulation. Patients with Fanconi Anemia (FA) are more sensitive to oxidative stress that could alter the expression of STC1. Our aim was to assess whether pa...

hrp0098p1-300 | Late Breaking 1 | ESPE2024

The Diagnostic and Therapeutic Monitoring Value of Morning Urinary Gonadotropins for Central Precocious Puberty in Girls with Different BMI

Xu Huijiao , Yuan Xin , Wu Wenyong , Hu Zhijian , Chen Ruimin , Luo Xiaoping

Objective: To explore the diagnostic value of morning urinary gonadotropins for assessing central precocious puberty (CPP) in girls with varying BMI and the potential use of first morning voided urinary luteinizing hormone (FMV ULH) in monitoring CPP treatment.Methods: A total of 335 precocious puberty girls were selected. Data of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), gonadotropin-releasing ...

hrp0098p2-70 | Diabetes and Insulin | ESPE2024

Efficacy of Advanced Hybrid Closed-Loop System Medtronic MiniMed™ 780G in Japanese children with type 1 diabetes mellitus (T1DM)

Ujita Nagisa , Yamada Mihoko , Horikawa Reiko

Background: MiniMed™ 780G was launched in Japan in November 2023 and is expected to further improve glycemic control.Objectives and Methods: 】Subjects of this study were 29 patients with T1DM, aged 2-18 years (average 8.8 years old), who have been treated by SAP using MiniMed™ 770G for at least 3 months prior to switching to 780G smart guard system. We divided subjects into 2 groups by HbA1c levels ove...

hrp0098p2-114 | Fat, Metabolism and Obesity | ESPE2024

The Association between Metabolic markers, Liver function enzymes, Vitamin D level, and Lung Function Tests in Overweight/obese Children with and without Asthma

Noor Safa , Hamdoun Elwaseila , Shailesh Harshita , Hani Yahya , Belavendra Antonisamy , Hasabelgawi Lina , Janahi Ibrahim

Introduction: The coexistence of asthma and obesity presents a significant clinical challenge, as both conditions independently contribute to systemic inflammation, metabolic dysregulation, and impaired respiratory function. Metabolic markers can potentially provide insights into the pathophysiological mechanisms that link obesity and asthma. The aimof this study was to investigate the association between metabolic markers, vitamin D and lung function in child...