ESPE Abstracts

Background: Congenital hypothyroidism (CH) can be categorized into two types: transient CH (group T) and permanent CH (group P). Several studies have recently demonstrated that the levothyroxine (LT4) dosage is useful for predicting LT4 requirement; however, none of the studies followed up their patients to puberty.Objective: To determine the cutoff value for the LT4 dosage as a predictor of LT4 requirement after puberty...

Abstract: Diabetic ketoacidosis(DKA) is a potentially fatal complication in patients with type 1 diabetes mellitus(T1DM). The mainstay of treatment for DKA is correction of dehydration and correcting hyperglycaemia with insulin. Intravenous(IV) insulin is preferred over subcutaneous(SC) insulin as onset of action is rapid and the dose can be titrated based on blood glucose.Aims: To compare efficacy and hospitalisation co...

Introduction: Vitamin D activity is controlled by its receptor (VDR). Increased risk of obesity and metabolic disturbances among certain VDR alleles has been proven. This study was conducted to assess the association between Cdx2 (rs11568820) polymorphism of VDR gene (genotypes: AG, GG) and genetic susceptibility to components of the lipid profile in survivors of acute lymphoblastic leukemia (ALL) treated during childhood.<stron...

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessively transmitted disease and 95% of CAH cases are due to 21-hydroxylase deficiency (21-OHD). There are more than 100 mutations that cause CAH due to 21-OHD and the clinical expression of the disease is reported to correlate with mutated alleles.The aim: The aim of this study was to investigate responsible mutations and then to evaluate genotype...

Objective: The aim of this study was to compare the psychometric and psychosocial profile of children and adolescents survivors of pediatric cancer to that of healthy controls.Methods: Children and adolescents survivors of pediatric cancer, aged 7–17 years, who attended the Hematology-Oncology Unit of the First Department of Pediatrics, and healthy controls who visited the Centre for Adolescent Medicine and UNESCO Chair on Adolescent Health Care of ...

Objective: To know more about the etiology and mechanism of antibody-negative diabetes, screening MODY pathogenicity genes and deepening understanding of islet autoantibody-negative diabetes, so as to individualized precision treatment.Methods: A total of 31 subjects with diabetes who had negative islet autoantibodies and C-peptide ≥0.3 ng/ml were collected. Another group was the type 1 diabetes control group, After informed consent obtained patien...

Aim: To determine the efficiency of α-lipoic acid in metabolic syndrome treatment in children.Materials and methods: 44 children with metabolic syndrome are observed. The diagnosis of metabolic syndrome is made on the base of obesity, arterial hypertension, disorders of carbohydrate and lipid metabolism according to the ATP III (2001) &icy; IDF (2005) recommendations. All patients are randomized into 2 groups: 22 ch...

Background: Pediatric hypertension is a risk factor for adult hypertension and cardiovascular disease which entails the necessity of early detection.Aim: To investigate how nutrition habits are correlated with systolic blood pressure (SBP) in health children and adolescent population.Methods: 1395 children and adolescents from Greece were enrolled to participate in the research. A specially designed questionnaire regarding to eatin...

Introduction: The impact of gestational diabetes mellitus (GDM) on fetal development and the future health of the child need further studying. In accordance to the criteria by Hyperglycemia and Adverse Pregnancy Outcome Study, GDM can lead to a number of negative consequences, including the impact on disturbance of metabolic parameters.Aim: To compare the impact of glycemia during pregnancy on the children’s metabolic status.M...

Introduction: Delayed or absent puberty is thought to be common in boys with Duchenne Muscular Dystrophy (DMD).Objective: To evaluate testicular development, function and puberty in DMD in a 12 months prospective longitudinal study.Methods: Thirty-four boys had assessment of puberty and testes volume by a single endocrinologist. Testes volumes were converted to Z-scores adjusted for bone age. Boys were divided into group A [Baselin...