hrp0098p1-43 | Fat, Metabolism and Obesity 1 | ESPE2024

BIO-STREAMS: Multi-Pillar Framework for children Anti-Obesity Behavior building on an EU biobank, Micro Moments and Mobile Recommendation Systems

Kassari Penio , Genitsaridi Sofia-Maria , Ramouzi Eleni , Giannopoulou Eleni , Kokkou Eleni , Papadopoulou Marina , Koutaki Diamanto , Stefanou Garyfallia , Nikitas Christos , Bibas Athanasios , Prasinos Marios , Brisimi Theodora , Pitoglou Stavros , Georga Eleni , Mlakar Ιzidor , Kontogianni Meropi , Matsopoulos George , Koutsouris Dimitris , Charmandari Evangelia , behalf of BIO-STREAMS Consortium on

Introduction: The World Health Organization (WHO) European Regional Obesity Report 2022 stated that obesity rates have reached epidemic proportions across the European Union (EU). Obesity affects nearly one in three children (29% of boys and 27% of girls), and is associated with adverse psychological and psychosocial outcome and increased risk for noncommunicable diseases (NCDs). In addition, none of the 53 Member States are on track to meet the target of stop...

hrp0098p2-320 | Late Breaking | ESPE2024

Screening for celiac disease in children and adolescents with type 1 diabetes, what to do?

Pilar Achón Buil Ana , García-Boente Marina , Constanza Matus Sáez Tania , García Cuartero Beatriz , Alkadi Fernández Khusama , Martín Frías María , Corredor Andrés Beatriz , Roy Ariño Garbiñe , Yelmo Valverde Rosa , Belén Roldán Martín María

Introduction: The reported prevalence of celiac disease (CD) in paediatric patients with type 1 diabetes mellitus (T1D) ranges from 1.6 to 16.4%, with a tendency to increase in recent years. Most clinical guidelines recommend screening for CD at the diagnosis of T1D but conclude different recommendations regarding subsequent screening, hence the importance of providing new data in this population group.Methods: We presen...

hrp0095p1-420 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Skeletal phenotype in patients with the monogenic Mulibrey nanism disorder

Karlberg Susann , Toiviainen-Salo Sanna , Lipsanen-Nyman Marita , Mäkitie Outi

Background: Mulibrey nanism (MUL) is a monogenic growth disorder with typical craniofacial features, perimyocardial heart disease, infertility and predisposition to tumors. MUL is caused by mutations in the TRIM37 gene encoding TRIM37 protein possessing E3 ubiquitin-ligase activity.Objective and hypotheses: MUL patients have pre- and postnatal growth failure with an average birth length SDS of -3.1 and birth weight SDS o...

hrp0082p2-d2-379 | Fat Metabolism & Obesity (1) | ESPE2014

Severe Childhood-Onset Obesity and Testicular Function After Puberty

Laakso Saila , Viljakainen Heli , Lipsanen-Nyman Marita , Turpeinen Ursula , Saukkonen Tero , Makitie Outi

Background: Obesity has in males been associated with reduced testosterone levels during and after puberty. However, the onset and progress of puberty into fertility in obese boys remain inadequately evaluated.Objective and hypotheses: We aimed to study testicular function at the end of pubertal development (15–24 years) in males with severe childhood-onset obesity (height-adjusted relative weight exceeding 160% before the age of 7 years).<p cla...

hrp0084p3-1085 | Perinatal | ESPE2015

Circadian Variation in Cortisol Concentration in Mother’s Milk

van der Voorn Bibian , Heijboer Annemieke , de Waard Marita , Verheijen Hester , Rotteveel Joost , Finken Martijn

Background: In mammals, maternal glucocorticoids are transmitted through breast milk, particularly under stressful circumstances. In humans, it is unclear whether milk cortisol levels are dependent on stressful perinatal circumstances, such as preterm birth.Objective and hypotheses: Our aim was to compare cortisol concentrations in breast milk of mothers of very preterm infants (GA <32 weeks) to breast milk cortisol concentrations of mothers of full-...

hrp0097p2-177 | Fat, Metabolism and Obesity | ESPE2023

Correlations between the degrees of obesity and dyslipidemia in a pediatric population from Romania

Amalia Ioana Arhire , Papuc Teodora , Miruna Sanziana Chiper , Chiriac Malina , Stoica Alexandra , Tambrea Elena

Keywords: pediatric obesity, metabolic syndrome, dyslipidemia, abdominal obesity, cardiovascular risk.Introduction: The prevalence of pediatric obesity is rising globally as well as in Romania and so are the complications of obesity. Dyslipidemia is one of the most frequent complications and is associated with cardiovascular risk even in children or teenagers. Evaluating the degree of obesity and the correlations between...

hrp0092p3-55 | Diabetes and Insulin | ESPE2019

The Role of Patient Adherence to Insulin Pump Therapy with Long-Term Treatment of Type 1 Diabetes

Turkunova Mariia , Bashnina Elena , Tsargasova Irina , Klitsenko Olga , Berseneva Olga

Background: Insulin pumps are widely used in the treatment of type 1 diabetes mellitus (T1D) in children because of numbers of advantages in compare with multiple daily insulin injections (MDI). However, the long-term efficacy of continuous subcutaneous insulin infusion therapy (CSII) in achieving and maintaining of diabet stability is still not resolved.Purpose: Determine the feffectiveness-related factors of glycemic c...

hrp0092p3-150 | GH and IGFs | ESPE2019

Features of Somatropin Replacement Therapy in a Patient with Floating Harbor Syndrome

Berseneva Olga , Bashnina Elena , Turkunova Mariia , Serebryakova Elena

Background: Growth hormone (GH) deficiency in children, confirmed by stimulation diagnostic tests, in some cases is accompanied by low effectiveness of somatropin replacement therapy, which may be associated with rare genetic syndromes.Aim: To study the growth effects of GH therapy in treating a patient with Floating-Harbor SyndromeMethods: A GH deficiency was diagnosed in a patien...

hrp0084p1-56 | DSD | ESPE2015

Immunohistochemical Detection of Estrogen α and Androgen Receptors in Genital Tissues in Girls with Congenital Adrenal Hyperplasia

Kopylova Irina , Orlova Elizaveta , Sysoeva Veronika , Glybina Tatyana , Kareva Mariia

Background: Introital stenosis in CAH girls could occur due to poor estrogenisation of vaginal tissue. It is unknown whether CAH genital skin is equally capable of responding to estrogens and androgens, depending on form and degree of external virilisation.Objective and hypotheses: To determine the levels of oestrogen α (ERa) and androgen receptors (AR) immunoreactivity in genital tissues of girls with CAH.Method: Surgical was...

hrp0097p1-118 | Growth and Syndromes | ESPE2023

The effect of growth hormone therapy on body composition in girls with Turner syndrome – a 10-year follow-up.

Błaszczyk Ewa , Shulhai Anna-Mariia , Gieburowska Joanna , Gawlik Aneta

Background: Obesity and a thicker layer of subcutaneous adipose tissue are more common in Turner syndrome (TS), however, it is assumed that growth hormone (GH) treatment has beneficial effect on their body composition (BC). Objective: To investigate the effect of GH therapy on BC and its relation with metabolic syndrome components in girls with TS during a 10 year-follow-up.Patients and Methods: 21 girls with TS were des...