hrp0094p1-164 | Growth B | ESPE2021

Long-term efficacy and safety of rhGH in children with SHOX deficiency: preliminary data of a national Italian survey (on behalf of ISPED Study Group on Growth Factors and Puberty).

Bruzzi Patrizia , Vannelli Silvia , Scarano Emanuela , Street Maria Elisabeth , Parpagnoli Maria , Trettene Adolfo Andrea , Wasniewska Malgorzata , Madeo Simona Filomena , Iughetti Lorenzo ,

Background: The phenotypic spectrum of short stature homeobox-containing gene deficiency disorders (SHOX-D) ranges from non-specific short stature to Leri-Weill dyschondrosteosis. Current guidelines support rhGH in SHOX-D children, but long-term data are still lacking. Moreover, no correlation has been established yet between the severity of phenotype, including the response to rhGH, and the underlying SHOX pathogenic variant.Aims: To ev...

hrp0094p2-124 | Diabetes and insulin | ESPE2021

Psychological changes in youth with diabetes: comparison between preadolescents and adolescents

Longaretti Roberta , Pozzi Clara , Trezzi Cecilia , Achutegui Irune , Docente Chiara , Langone Marta , Favalli Valeria , Frontino Giulio , Rigamonti Andrea , Di Tonno Raffaella , Bonfanti Riccardo ,

Background: The course of type one diabetic disease (T1DM) varies according to the period of life and in response to various external or internal factors. Adolescence is an evolutionary phase that involves important developmental changes and identity construction. Diabetes disease and its management, especially in this life period, can lead to psychological distress and impact on Self-redefinition.Method: We conducted a ...

hrp0097fc3.6 | Fat, metabolism and obesity 1 | ESPE2023

Impact of Setmelanotide on Future Metabolic Syndrome Risk in Pediatric Patients With Bardet-Biedl Syndrome

Haqq Andrea , Poitou Christine , K. Chung Wendy , Iqbal Anoop , Forsythe Elizabeth , Malhotra Sonali , Touchot Nicolas , Clément Karine , Argente Jesús

Background: Children with metabolic syndrome carry an increased risk for development of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in adulthood. Patients with rare syndromic obesity, such as Bardet-Biedl syndrome (BBS), experience early-onset, severe obesity, which may convey an increased risk for developing obesity-related comorbidities and metabolic syndrome later in life. In clinical trials, treatment with the melanocortin-4 receptor a...

hrp0097rfc9.1 | Diabetes and insulin 2 | ESPE2023

The association of dietary glycemic index and load with insulin sensitivity and secretion from early childhood to late adolescence: the QUALITY cohort

Cattrysse Pascaline , Harnois-Leblanc Soren , Sallah Drammeh Pa , Drapeau Vicky , A. Barnett Tracie , Mathieu Marie-Ève , Suissa Karine , Benedetti Andrea , Henderson Mélanie

Introduction: With the increasing prevalence of obesity, prediabetes and type 2 diabetes (T2D) in youth are on the rise. Prevention is paramount for these multifactorial diseases. Dietary interventions targeting a reduction of dietary glycemic index (GI) and glycemic load (GL) are potential strategies for improving insulin resistance. However, the association between GI and GL and T2D risk in children remains uncertain.Objectives...

hrp0097p1-46 | Diabetes and Insulin | ESPE2023

Associated autoinmmunity in children and adolescents with type 1 diabetes mellitus

Reinoso Andrea , García Rusca Elizabeth , Rosa Moreno Maria , Claudia Pérez María , Fasano Victoria , Balbi Viviana , Morín Analía , Pietropaolo Guadalupe

Introduction: Autoimmune thyroid diseases (ATD) are the most common autoimmune disorders associated with type 1 diabetes (T1D). Most patients present hypothyroidism. Although hyperthyroidism is less frequent, severe forms of thyrotoxicosis coexisting with diabetic ketoacidosis (DK) have been described in children with either preexisting diabetes, thyroid disease, or both. Celiac disease (CD) incidence is higher and ranges from 0.6-16.4%....

hrp0097p1-92 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Relationship between birth body weight<10.th centile (sga) and insulin-like growth factor binding protein-3: relevance of birth chest circumference / birth body weight ratio independently of birth gestational age, insulin-like growth factor binding protein-1 and -2 in the not-life threatened newborn

Terzi Cesare , Virdis Raffaele , Magnani Cristiana , Tridenti Gabriele , Cerioli Andrea , Riani Marco , Garavelli Lidia , Luigi De Angelis Gian , Bernasconi Sergio , F. Blum Werner , Banchini Giacomo

Birth chest circumference(CC) shows often, like birth gestational age(GA), tight direct relations to birth body weight(BW). However distinct connections of hypoxia/undernutrition with different body structures might be suspected based on brain-, heart- and adrenal-sparing following intrauterine growth restriction and, postnatally, on higher chest size for body mass observed at high altitude. Growth retarded fetuses gestated by hypoxic pregnant animals may present increments of...

hrp0097p1-484 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Relationships between birth body weight<10.th centile (SGA) and insulin-like growth factor-ii / insulin-like growth factor binding protein-3 ratio in the not-life threatened newborn: relevance of birth chest circumference / birth body weight ratio and oxygen supplementation

Terzi Cesare , F. Blum Werner , Magnani Cristiana , Tridenti Gabriele , Cerioli Andrea , Riani Marco , Chesi Elena , Luigi De Angelis Gian , Bernasconi Sergio , Virdis Raffaele , Banchini Giacomo

Direct relationships of estimated birth brain weight(BRW) to birth body weight (BW) ratios (BBR) and of BW<=10.th centile for GA(SGA) with blood serum Insulin-like Growth Factor-II(IG2) to blood serum Insulin-like Growth Factor Binding Protein-3 (IB3) ratios (IG2/IB3R), and inverse relations between BW-SDS and birth chest circumference(CC) / BW ratio (i.e., CC through BW; CC/BWR) have been detected by our group in the human newborn(NWB). We evaluated the possibility that CC...

hrp0097p1-583 | Thyroid | ESPE2023

Was newborn screening for congenital hypothyroidism affected by COVID19 lockdown?

Vitale Laura , Esposito Mariela , Francesca Jesica , Victoria Fasano María , Balbi Viviana , Tournier Andrea , Borrajo Gustavo , González Verónica , Morín Analía

Mandatory lockdown during COVID 19 pandemic obstaculized access to medical attention. Newborn screening (NBS) for congenital hypothyroidism (CH) in Buenos Aires province has been obligatory since 1995 and performed sustainedly. CH causes mental delay if not diagnosed and treated early.Objectives: The aim of this study was to determine if mandatory lockdown changed time of established NBS diagnosis steps.Mat...

hrp0098fc13.5 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

Rising in body mass index during childhood in girls with idiopathic CPP: a 20-year experience in a tertiary Belgian centre.

Vicinanza Alfredo , Baro Keno Deressa Obsse , Nebbioso Andrea , Ulgiati Fiorenza , Lambert Sophie , Tenoutasse Sylvie , Boros Emese , Heinrichs Claudine , Brachet Cécile

Introduction: Numerous studies highlighted a secular trend toward earlier puberty. Several factors, including nutrition and migration, may explain this trend. It is known that girls born small for gestational age (SGA) start puberty at a younger age compared to those born average for gestational age (AGA) and that overweight in childhood may be a risk factor for central precocious puberty (CPP), especially in girls. This study mainly aims to compare the evolut...

hrp0098p1-184 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Assessment of hypogonadotropic hypogonadism using a gonadotropic-gonadal stimulation test with subcutaneous Triptorelin: preliminary results.

Freire Analía , Arcari Andrea , Gabriela Ballerini María , Grinspon Romina , Castro Sebastian , Eugenia Rodriguez María , Gryngarten Mirta , Keselman Ana , Braslavsky Débora , Bergadá Ignacio , Rey Rodolfo , Gabriela Ropelato María

Introduction: Comprehensive evaluation of the gonadotropic axis, including pituitary and gonadal assessment, using a diagnostic test with aGnRH (Triptorelin) could be useful in the differential diagnosis between hypogonadotropic hypogonadism (HH) and self-limited delayed puberty (SLDP) or amenorrhea of unknown cause.Objective: To assess the performance of the Triptorelin test for the diagnosis of HH and to compare it wit...