hrp0092p1-178 | Diabetes and Insulin (1) | ESPE2019

The Efficacy and Safety of Predictive Low Glucose Suspend Feature in Decreasing Hypoglycemia in Children with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Alotaibi Ahlam , Alkhalifah Reem , McAssey Karen

Background: Hypoglycemia is a common side effect of insulin replacement therapy in patients with type 1 diabetes mellitus (T1DM). With the advancement of diabetes technology, sensor-augmented pump therapy (SAP) with predictive low glucose suspend feature offers a potential solution for hypoglycemia in patients with T1DM. However, evidence from randomized trials about the efficacy and safety of PLGS is limited.Method: We ...

hrp0094p2-91 | Bone, growth plate and mineral metabolism | ESPE2021

Two-year experience of burosumab therapy in pediatric XLH patients in Saudi Arabia

AlJuraibah Fahad , Aldubayee Mohamed , Alsagheer Afaf , Shaikh Adnan Al ,

Background: X-linked hypophosphatemia (XLH) is a rare, often debilitating genetic disorder caused by mutations in the phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) that is characterized by excess fibroblast growth factor 23 (FGF23), hypophosphatemia, skeletal deformities, and growth impairment.1,2 Conventional therapy with the combination of phosphate and active vitamin D is associated with poor treatment adh...

hrp0097rfc8.4 | Fat, metabolism and obesity 2 | ESPE2023

Understanding the genetics of early onset obesity in a cohort of children from Qatar

Mohammed Idris , Haris Basma , Al-Barazenji Tara , Vasudeva Dhanya , Tomei Sara , Al Azwani Iman , Dauleh Hajar , Shehzad Saira , Chirayath Shiga , Mohamadsalih Ghassan , Petrovski Goran , Khalifa Amel , love Donald , Al-Shafai Mashael , Hussain Khalid

Context: Monogenic obesity (MO) is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early-onset obesity. Mutations in the MC4R and Leptin genes are the commonest causes of MO. Determining the genetic causes has important clinical benefits as novel therapeutic interventions were developed for some forms of MO.Objective:<...

hrp0089p2-p061 | Diabetes &amp; Insulin P2 | ESPE2018

The Prevalence of Double Diabetes in Children and Adolescents in Qatar

Soliman Ashraf , Alyafei Fawzia , Wasfy Reem , Aldarsy Nagwa

The incidence of both type 1 (T1DM) and type 2 diabetes (T2DM) has shown a rise in Qatar in parallel with a notable increase in the incidence of a new expression of the disease in children and adolescents, with the characteristics of a mixture of the two types of diabetes and referred to as ’double diabetes’ (DD). Insulin resistance and obesity, together with the presence of markers of pancreatic autoimmunity - namely, autoantibodies to islet cell antigens - typicall...

hrp0097p1-378 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Infant with 45, XO DSD presented with Li Fraumeni syndrome, a case report from Kuwait.

Alfadhli Maryam , Alhenaidi Razan , Elshafie Reem , Alkandari Hessa , Alhomaidah Doha

Background: X-chromosome monosomy is the most common sex abnormality in females, with a higher prevalence of cancer than the general population. Virilizing adrenocortical tumors are rarely seen in patients with Turner’s Syndrome. There have been 2 reported cases of simultaneous TP53 mutations (Li Fraumeni’s syndrome) and Turner’s syndrome. Here we report first case with this rare association from Kuwait.Clinical...

hrp0098fc6.1 | Fat, Metabolism and Obesity 1 | ESPE2024

Corneal Nerve Loss and regeneration after GLP-1 Therapy in Children with Simple and Monogenic Obesity

Gad Hoda , Dauleh Hajar , Chirayath Shiga , Amin Rasha , Mohamadsalih Ghassan , Pasha Maheen , Mohammed Idris , Al-Barazenji Tara , Khalifa Amel , Petrovski Goran , Hamdoun Elwaseila , Al Bureshad Khalid , Ibrahim Marwa , A. Malik Rayaz , Hussain Khalid

Background: Obesity is highly prevalent in the MENA region, especially in children and it has been associated with neurodegeneration. We have undertaken corneal confocal microscopy (CCM) to assess for evidence of neurodegeneration in children with simple obesity and monogenic obesity (MC4R gene mutation) and further assessed the effect of glucagon-like peptide 1 agonist (GLP-1) therapy on corneal nerve regeneration.Methods:</stro...

hrp0098p1-35 | Diabetes and Insulin 2 | ESPE2024

Diabetes Mellitus in Woodhouse -Sakati syndrome

Amin Rasha , Khalifa Amel , Petrovski Goran , Mohammed Elwaseila , Dauleh Hajar , Haris Basma , Chirayath Shiga , Mohamadsalih Ghassan , Al Bureshad Khalid , Ibrahim Marwa , Hussain Khalid

Background: Woodhouse-Sakati syndrome (WSS) is a rare, autosomal recessive genetic disorder with variable clinical manifestations mainly affecting the endocrine and nervous systems. Diabetes mellitus is one endocrine manifestation but there are no comprehensive data on the epidemiology, clinical features, underlying mechanisms, and management, particularly within the Qatari population.Methods: This retrospective study wa...

hrp0089p2-p060 | Diabetes &amp; Insulin P2 | ESPE2018

Incidence of Childhood Type 1 and Type 2 Diabetes Mellitus in Qatar between 2012–2016

Alyafei Fawziya , Soliman Ashraf , Alkhalaf Fawziya , Waseef Reem , Abdulkayoum Anas , Sayed Ahmed , Eldarsy Nagwa , Sabt Aml

Introduction: The overall age-adjusted incidence of type 1 diabetes (T1DM) varied from 0.1/100,000 per year in China and Venezuela to 36.8/100,000 per year in Sardinia and 36.5/100,000 per year in Finland. This represents a 350-fold variation in the incidence among the 100 populations Worldwide. In the early 1990s, T2DM it was representing about 3 percent only of pediatric diabetes in the United States, but by 2003, T2DM reached about 20 percent of pediatric diabetes.<p cl...

hrp0089p3-p080 | Diabetes &amp; Insulin P3 | ESPE2018

Clinical and Biochemical Characteristics of Familial Type 1 Diabetes Mellitus (FT1DM) Compared to Non-Familial Type 1 DM (T1DM)

Alyafei Fawzia , Soliman Ashraf , Alkhalaf Fawziya , Sabt Amal , Waseef Reem , Eldarsy Nagwa , Abdulkayoum Anas , Umer Fareeda

Introduction: The clinical and genetic characteristics of T1D cases with and without affected family members have been previously studied with varying results. Some investigators found a similarity of presenting features whereas others reported significant differences between the two groups.Patients and methods: This was a cross sectional descriptive study to determine the clinical presentation and prevalence of beta cell autoimmunity (Anti GAD, anti-isl...

hrp0089p3-p081 | Diabetes &amp; Insulin P3 | ESPE2018

Prevalence of Beta-cell Antibodies and Associated Autoimmune Diseases in Children and Adolescents with Type 1 (T1DM) vs Type 2 Diabetes Mellitus (T2DM) in Qatar

Alyafei Fawzia , Soliman Ashraf , Alkhalaf Fawziya , Sabt Aml , Waseef Reem , Eldarsy Nagwa , Algamal Mona

Introduction: Type 1 diabetes (T1DM) is an autoimmune disease with abnormal immune responses to specific β-cell autoantigens, resulting in insulin deficiency. Children and adolescents with T1DM may also develop organ-specific autoimmunity. The most frequently reported disorders are thyroid dysfunction and celiac disease. There are limited previous studies on the prevalence of associated autoimmunity, especially multiple, in children with T1DM.Aim: T...