hrp0084p3-893 | Fat | ESPE2015

Experience with Sleeve Gastrectomy in Adolescent Obese Subjects and in Prader-Willi Syndrome

Fintini Danilo , Bocchini Sarah , Caccamo Romina , Grugni Graziano , Cappa Marco , De Peppo Francesco , Crino Antonino

Background: Prader Willi syndrome (PWS) results from the loss of paternally imprinted genes on chromosome 15q11–15 and is characterized by neonatal hypotonia, short stature, hypogonadism, aggressive food-seeking behavior, hyperphagia, and obesity with difficult in losing weight only with nutritional approach.Objective and hypotheses: We report our experience on sleeve gastrectomy in PWS and obese subjects during 12 months of follow-...

hrp0094fc9.4 | Growth Hormone and IGFs | ESPE2021

Optimising adherence using a connected injection device can improve growth outcomes: Evidence from real-world data on 11 million injections in 20,000 patients with growth disorders

Koledova Ekaterina , Bagha Merat , Arnaud Lilian , Piras Francesco , van Dommelen Paula ,

Background: For early identification of patients requiring adherence support, objective, real-time adherence data are needed. The easypod™ electromechanical injection device, in combination with the easypod™ connect ecosystem, electronically records and transmits, in real time, accurate records of the date, time and dose injected for patients receiving recombinant human growth hormone (r-hGH) to treat growth disorders. Healthcare professionals can us...

hrp0097rfc8.6 | Fat, metabolism and obesity 2 | ESPE2023

Leukocytes and Neutrophil–Lymphocyte Ratio as Indicators of decreased insulin sensitivity in NGT Overweight and Obese Children with high 1-hour post-load plasma glucose levels

Mastromauro Concetta , Lauriola Federico , Matonti Lorena , Trisi Giulia , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: Obese children with normal glucose tolerance (NGT) but with 1-hour post-load plasma glucose (1hPG) ≥ 132.5 mg/dl are at higher risk of developing type 2 diabetes (T2D) and cardiometabolic complications. In addition, new markers of systemic inflammation derived from blood cell count could be used as indicators of insulin resistance, thus predicting worse metabolic profile.Objective: The aim of our study w...

hrp0097p1-202 | Adrenals and HPA Axis | ESPE2023

Increased adiposity and insulin resistance negatively affect growth in pre-pubertal heterozygote carriers of 21-Hydroxylase deficiency

Mascioli Ilaria , Mastromauro Concetta , Lauriola Federico , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: 21-Hydroxylase deficiency (21-OHD) is the archetype of congenital adrenal hyperplasia (CAH). Deficiency of 21-Hydroxylase results in an impairment of cortisol synthesis, which is critical in stressful conditions when higher output is required to restore homeostasis. In addition, an increased androgen production, might results in undesirable manifestations of hyperandrogenism, as menstrual abnormalities, infertility and cosmetic annoyances and gro...

hrp0097p1-52 | Fat, Metabolism and Obesity | ESPE2023

Effects of Relaxation of COVID-19 restriction measurements on glucose and insulin metabolism in overweight and obesity youth

Matonti Lorena , Trisi Giulia , Mastromauro Concetta , Di Pietro Giada , Chiarelli Francesco , Giannini Cosimo , Mohn Angelika

Background: COVID-19 restriction measurements have determined profound alterations in glucose and insulin metabolism in children with overweight and obesity. However, to date few data have explored the effects of the relaxation of restrictions in the pediatric population. Thus, we compared anthropometric and OGTT data in children with overweight and obesity during the two years after (2021-2023) compared to the two years during (2020-2021) and before (2018-201...

hrp0097p1-80 | Fat, Metabolism and Obesity | ESPE2023

Leukocyte, platelet counts and the neutrophil-to-lymphocyte ratio (NLR) are related to insulin resistance in obese and overweight children

Lauriola Federico , Mastromauro Concetta , Mascioli Ilaria , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Background and aims: The development of insulin resistance (IR) may be influenced by inflammation in overweight/obese individuals. To identify indicators of IR, new markers of inflammation and systemic inflammation such as leukocyte (WBC) and platelet counts (PLT), the neutrophil-to-lymphocyte ratio (NLR) have been suggested. This study aims to investigate the association between these markers and IR in a group of overweight and obese.<s...

hrp0098p2-89 | Diabetes and Insulin | ESPE2024

Testing a new “accelerator hypothesis” covid-19 pandemic-related in new onset pediatric type 1 diabetes: a retrospective analysis 2010-2022

Iannucci Daniela , Mastromauro Concetta , Cicolini Ilenia , Chiarelli Francesco , Giannini Cosimo , Blasetti Annalisa

Background: An increased incidence of Type 1 diabetes has been observed worldwide over the past 30 years. Obesity is a well-documented risk factor for Type 2 diabetes (T2D), but poor studies have postulated an association between the obesity and overweight and the rate of T1D in these age groups. This is known as Accelerator Hypothesis. In addition, a further effect seems to be exerted COVID-19 pandemic which is related to raised rate of T1D onset and obesity....

hrp0098p2-122 | Fat, Metabolism and Obesity | ESPE2024

The role of obesity on lung function in children and adolescents with asthma

Attanasi Marina , Di Filippo Paola , Mastromauro Concetta , Lauriola Federico , Di Pillo Sabrina , Chiarelli Francesco , Giannini Cosimo

Introduction: Children with obesity are at higher risk of asthma. It is known the relationship between asthma and obesity in children demonstrated by altered lung function in obese compared to normal weight children. However, few studies have evaluated changes in lung function in obese asthmatic patients undergoing therapy.Objective: The aimwas to evaluate the role of weight gain in the development of spirometry alterati...

hrp0092lb-20 | Late Breaking Posters | ESPE2019

Introduction of Flash Glucose Monitoring in Children with Type 1 Diabetes: Experience of a Single-Centre in Spain

Leiva-Gea Isabel , Garcia Vázquez Javier , Rocío Liñán Jurado Francisca , Angel Maese Ruiz Miguel , Jiménez Hinojosa Jose , Pedro López-Siguero Juan

Flash glucose monitoring is now included in the Portfolio of Services of the Public Health System of Andalusia in Spain. We enrolled 145 paediatric T1D diabetes patients into a prospective, interventional study of the impact of the FreeStyle Libre system on HbA1c levels in this population, as well as additional measures of glycemic health, such as Time in Range (TIR) and Time Below Range (TBR). Subjects were trained in use of the FreeStyle Libre system at the start of the stud...

hrp0089rfc1.6 | Adrenals &amp; HPA Axis | ESPE2018

A Laboratory Harmonization Strategy for Steroid Hormone Profiling by MoM-Transformed, Normalized Reference Ranges Independent of Age, Sex and Units

Kulle Alexandra E , Zalas Dominika , Reinehr Thomas , Niedziela Marek , Borzikowsky Christoph , Pinto Francisca , Baumann Juliane , Flader Maciej , Simic-Schleicher Gunter , Akkurt Halit Ilker , Heger Sabine , Hornig Nadine , Holterhus Paul-Martin

Background/aims: The high complexity of Pediatric reference ranges across age, sex and units impairs clinical application and comparability of steroid hormone data, e.g., in CAHs. We developed a Multiples-of-Median (MoM) normalization tool to overcome this major drawback in Pediatric Endocrinology.Methods: LC–MS/MS data comprising 10 steroid hormones representing 905 controls (555 males, 350 females, 0 to >16 years) from two previous datasets we...