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Purpose: A decline in the age of pubertal onset and increases in the prevalence of central precocious puberty (CPP) have recently been widely reported throughout the world. Based on national population data, this study was conducted to analyze Korea's CPP incidence rate.Methods: Between 2012 and 2020, data from the Korean national health insurance service for girls aged 8 years and younger and boys aged 9 years and ...

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hrp0097p2-62 | Diabetes and Insulin | ESPE2023

Growth patterns according to glycemic control, CGM apply, and diabetic complications in type 1 diabetes mellitus patients

Suh Junghwan , Kim Sujin , Lee Myeongseob , Song Kyungchul , Kwon Ahreum , Wook Chae Hyun , Kim Ho-Seong

Introduction: Chronic diseases such as type 1 diabetes mellitus (T1DM) may alter linear growth, but previous reports regarding growth in children with T1DM has been inconsistent. This study aims to investigate height and growth velocity of T1DM patients after diagnosis of diabetes and whether they are affected by various factors.Methods: This retrospective study, included 151 patients (male, 45.0%; mean age at diagnosis,...

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hrp0097p2-32 | Fat, Metabolism and Obesity | ESPE2023

The prevalence and risk factors of non-alcoholic fatty liver disease in obese and normal weight children in Latvia

Gailite Jurgita , Petrosina Eva , Gardovska Dace , Dzivite-Krisane Iveta

Background: Public health research shows that the prevalence of obesity is increasing rapidly not only among adults, but especially among adolescents and children. Obese children and adolescents are at risk of early chronic complications such as cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus, various types of tumors, orthopedic problems, serious psychological and neurological problems.<strong...

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hrp0095fc8.1 | Diabetes and Insulin | ESPE2022

Clinical effectiveness of Liraglutide 3.0 mg for weight management as an adjuvant therapy in obese adolescents with type 1 diabetes: A single-center pilot study

Elbarbary Nancy

Background: Recent data from multiple international registries showed higher rates of overweight and obesity in adolescents with type 1 diabetes (T1DM) compared with their non-diabetic peers. Management of weight gain should be emphasized as obesity is a modifiable cardiovascular risk factor. Liraglutide is a glucagon like peptide&dash;1 receptor agonist approved for chronic weight management in adolescents with body weight above 60 kg and body mass index (BMI...

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hrp0095rfc9.1 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a national observational study

Kjersgaard Jakobsen Louise , Beck Jensen Rikke , Holtum Birkebæk Niels , Hansen Dorte , Rønholt Christensen Ann-Margrethe , Thybo Christesen Henrik

Background: Congenital combined pituitary hormone deficiency (cCPHD) is the loss of ≥2 pituitary hormones caused by genetic or prenatal factors.Methods: For the period 1996–2020, patients with cCPHD were identified from the Danish National Patient Registry and the registries at the four Danish hospitals approved for the management of cCPHD. Retrospective hospital file reviews were performed to validate the diagn...

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hrp0095t12 | Section | ESPE2022

Assessment of non-alcoholic fatty liver disease with non-invasive indices in adolescents with polycystic ovary syndrome

Context: Polycystic ovary syndrome (PCOS) is a complex disorder affecting women from adolescence until menopause. PCOS in adolescent years shares common features with clinical presentation in adulthood, including the adverse metabolic profile. Non-alcoholic fatty liver disease (NAFLD) is a spectrum of hepatic changes, from liver steatosis to severe inflammation and fibrinogenesis.Objective: To assess NAFLD in an adolesce...

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hrp0095p1-13 | Adrenals and HPA Axis | ESPE2022

Clinical characteristics and pubertal development in Greek girls with premature adrenarche.

Athina Vlachopapadopoulou Elpis , Dikaiakou Eirini , Kosteria Ioanna , Athanasouli Fani , Kafetzi Maria , Michalacos Stefanos

Background: Premature adrenarche (PA) is characterized by the appearance of pubic and axillary hair associated with an increase in adrenal androgen production, in the absence of central puberty, steroidogenic enzyme defects, or virilizing tumors, before the age of 8 years in girls and 9 years in boys. Studies have shown increased likelihood of PA for children with obesity and those born small for gestational age (SGA).Aim:</stron...

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hrp0095p1-211 | Adrenals and HPA Axis | ESPE2022

Effect of maternal steroid medication prescribed during pregnancy on neonatal adrenal function

Ahmed Aneeq , Hattangadi Ibani , Gopalakrishna Nagapratheek , De Silva Shamani , Elder Charlotte , Ferguson Elspeth

Background: There is limited data supporting concerns that systemic corticosteroids, prescribed in pregnancy for maternal health reasons, can suppress the neonatal Hypothalamic-Pituitary-Adrenal (HPA) axis. Our study aimed to determine if neonates born to mothers on long-term or high dose steroids are at risk of adrenal suppression.Methodology: Neonates who underwent assessment of adrenal function over a seven-year perio...

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hrp0095p1-402 | Adrenals and HPA Axis | ESPE2022

Glucose regulation and cardiovascular health in children and young people with primary adrenal insufficiency

Park Julie , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Hypoglycaemia and poor cardiovascular outcomes are described in children and young people (CYP) with primary adrenal insufficiency (PAI). In this study, we described cortisol exposure during hydrocortisone replacement therapy, glucose regulation by continuous glucose monitoring (CGM) and cardiovascular function. Here, we present the final study data.Methods: CYP with PAI underwent CGM for 7 days using Dexcom ...

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hrp0095p1-37 | Diabetes and Insulin | ESPE2022

The role of insulin resistance and pancreatic β-cell dysfunction in the development of prediabetes in obese adolescents

MinkovaNadezda , Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Romaykina Daria , Samsonova Lubov

Background: The pathophysiology of type 2 diabetes mellitus (T2DM) is based on defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Young people have a more aggressive course of the disease. However, the impact and sequence of pathological mechanisms involved in the development of T2DM in adolescents hasn’t been established. Diagnosis of the prediabetes in time can be u...

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ESPE Abstracts

The incidence of central precocious puberty in Korea between 2012 and 2020, population-based study.

Growth patterns according to glycemic control, CGM apply, and diabetic complications in type 1 diabetes mellitus patients

The prevalence and risk factors of non-alcoholic fatty liver disease in obese and normal weight children in Latvia

Clinical effectiveness of Liraglutide 3.0 mg for weight management as an adjuvant therapy in obese adolescents with type 1 diabetes: A single-center pilot study

The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a national observational study

Assessment of non-alcoholic fatty liver disease with non-invasive indices in adolescents with polycystic ovary syndrome

Clinical characteristics and pubertal development in Greek girls with premature adrenarche.

Effect of maternal steroid medication prescribed during pregnancy on neonatal adrenal function

Glucose regulation and cardiovascular health in children and young people with primary adrenal insufficiency

The role of insulin resistance and pancreatic β-cell dysfunction in the development of prediabetes in obese adolescents

BiosciAbstracts