hrp0082p2-d1-415 | Growth Hormone | ESPE2014

IGF1 is Associated with a More Favourable Pattern of Body Composition in Obese Children

Inzaghi Elena , Pampanini Valentina , Alessio Paola , Fiori Rossana , Ferroli Barbara Baldini , Cianfarani Stefano

Background: Recent studies have suggested a role of IGF1 as a candidate prognostic marker for cardiometabolic complications of obesity.Objective: To investigate the relationship between IGF1 serum levels and both biochemical and metabolic parameters as well as body composition in a cohort of obese children.Methods: obese subjects (130F/157M), aged 11.2±2.7 years, were studied. Anthropometry, biochemical and metabolic parameter...

hrp0098p2-95 | Fat, Metabolism and Obesity | ESPE2024

The Effect of Vitamin D Supplementation on Fatty Liver Disease and Insulin Resistance

Anil Korkmaz Huseyin , Barisik Vatan , Atila Dincer , Cekdemir Yasin

Background: Vitamin D deficiency has been shown to increase fatty liver disease (FLD) incidence in patients with obesity (4,5). This study aim ed to determine the effects of a single dose of 300,000 IU cholecalciferol on insulin resistance and fatty liver disease (FLD) in children with obesity with vitamin D deficiency.Methods: In this clinical study, 128 patients aged 8-18 years with obesity and vitamin D deficiency wer...

hrp0095p1-153 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Urinary gonadotrophins as markers of puberty in girls and boys during late childhood and adolescence: Evidence from the SCAMP Cohort

Spiers Alexander , Patjamontri Supitcha , B Smith Rachel , Shen Chen , B. Toledano Mireille , Faisal Ahmed S

Introduction: Urinary gonadotrophins measurement is a noninvasive method for evaluation of pubertal development and may have utility in population studies.Objectives: To investigate the utility of urinary gonadotrophins as a noninvasive biomarker of puberty in boys and girls.Methods: School-based adolescent cohort study with two time points for collecting school time urine samples ...

hrp0089p2-p159 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum NAMPT Levels are not Associated with Parameters of Liver Function in Children and Adolescents

Penke Melanie , Schuster Susanne , Dietz Yvonne , Garten Antje , Grafe Nico , Karlas Thomas , Wiegand Johannes , Korner Antje , Kiess Wieland

Background/Aim: Serum NAMPT (nicotinamide phosphoribosyltransferase) levels are altered in adult patients with non-alcoholic fatty liver disease (NAFLD). However, less is known about NAMPT serum levels children and adolescents and their association with parameters of liver function.Methods: Blood and anthropometric data of 416 children and adolescents who participated in the LIFE Child Study Leipzig were collected. Serum NAMPT (Adipogen) and cytokeratin-...

hrp0095p1-464 | Fat, Metabolism and Obesity | ESPE2022

Triglyceride glucose index is associated with the severity of ultrasonographic fatty liver indicator in pediatric non-alcoholic steatohepatitis

Gyeol Kim Bit , Seo Yoon Jong , Tae Hwang Il

Background: Triglyceride glucose (TyG) index is known as a reliable insulin resistance surrogate marker to identify non-alcoholic fatty liver disease (NAFLD). Ultrasound fatty liver indicator (US-FLI) is proposed as a non-invasive, semi-quantitative method for predicting hepatitis in children with NAFLD and may reflect the severity of liver histological changes. US-FLI ≥4 has been suggested as a predictive finding for severe NASH. US-FLI correlates signific...

hrp0089p1-p061 | Diabetes & Insulin P1 | ESPE2018

The Prevalence of Autonomic and Peripheral Neuropathy in Children and Adolescents with Type 1 Diabetic Mellitus (T1D) and Its Association with the Homozygous Status of Z-2/Z-2 Polymorphism of the Aldose Reductase Gene (AKR1B1) in the Polyol Pathway

Kallinikou Dimitra , Tsentidis Charalampos , Kekou Kyriaki , Louraki Maria , Kanaka-Gantenbein Christina , Kanavakis Emmanouil , Karavanaki Kyriaki

Introduction: Diabetic neuropathy (DN) significantly reduces patients’ quality of life and increases cardiovascular death risk. However, it is the least recognized complication of diabetes. Z-2/Z-2 polymorphism of the aldose reductase (AKP1B1) gene increases the expression of the relative enzyme and is likely to contribute to DN expression.Purpose: To study the prevalence of DN in T1D children and adolescents and its associations with the h...

hrp0086p1-p484 | Fat Metabolism and Obesity P1 | ESPE2016

Fetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children

Joung Oh Yeon , Hee Yi Kyung , Jae Kang Min , Woo Baek Joon , Yang Seung , Tae Hwang Il

Background: Fetuin-A plays a role in insulin resistance and cardiovascular disease.Objective and hypotheses: The aim of present study was to determine the relation between fetuin-A levels and caridiometabolic risk factors and to investigate effect of serum fetuin-A to insulin sensitivity indices for determining whether fetuin-A is additional marker of insulin resistance in prepubertal children.Method: Ninety-nine prepubertal Korean...

hrp0086p1-p823 | Syndromes: Mechanisms and Management P1 | ESPE2016

Effects of a Stressful Environment (SE) on Height, BMI and Menarche

German Alina , Mesch Gustavo , Shmoish Michael , Hochberg Ze'ev

Background: Children’s exposure to stress predicts poor health. Poor growth and maturation are recognized indicators of poor health.Objective and hypotheses: SE correlates with height, BMI and menarche. We correlated seven indicators of SE with countries’ average adult height, BMI and menarche age.Method: Data for 57 countries of average men and women’s height, BMI and menarche age were collected from WHO report. The...

hrp0094p1-152 | Fetal Endocrinology and Multisystem Disorders B | ESPE2021

Impact of gestational weight gain on methylation of imprinted genes in umbilical cord and its relationship with postnatal growth and metabolism

Mas-Pares Berta , Carreras-Badosa Gemma , Gomez-Vilarrubla Ariadna , Xargay-Torrent Silvia , Maroto Anna , Prats-Puig Anna , Puerto-Carranza Elsa , Zegher Francis de , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel ,

Introduction: Imprinted genes are critical for placental function and normal fetal growth and development. Very little is known about the impact of maternal obesity on imprinted genes and their role in postnatal growth and metabolism.Objectives: 1) To identify umbilical cord DNA methylation sites (CpG) associated with gestational weight gain (GWG); 2) to identify which of these CpGs lie within imprinting control regions ...

hrp0095lb4 | Late Breaking | ESPE2022

The association between glycated albumin and HbA1c in pediatric acute leukemia patients

Yeun Sim Soo , Bae Ahn Moon , Suh Byung-Kyu

Introduction: Traditionally, HbA1c has been used as a preferred glycemic index in diabetes patients. However, as many acute leukemia patients often present with anemia and/or pancytopenia, HbA1c may not accurately represent blood glucose level in this group. Glycated albumin represents the average level of blood glucose in recent 2-3 weeks, independent of red blood cell life. In this study, we aim to evaluate the usefulness of glycated albumin as glycemic moni...