hrp0092p1-63 | Fat, Metabolism and Obesity | ESPE2019

Altered Gut Microbiota in Obese Children: Sex-associated Signature

Chen Ruimin , Ai Zhuanzhuan , Yang Xiaohong , Zhang Ying , Yuan Xin

Background: The incidence of obesity, especially in children, have dramatically increased over the last few decades. Recently, studies highlighted the involvement of gut microbiota in the pathophysiology of obesity. Gender-related differences have been reported in animal and adult. Nonetheless, reports related on the features of gut microbiota in children with obesity is limited and no one reported the different composition of gut microbiota at different sex o...

hrp0092p1-191 | Fat, Metabolism and Obesity (1) | ESPE2019

Effect of Probiotics Intake on Obese Children

Chen Ruimin , Ai Zhuanzhuan , Yang Xiaohong , Zhang Ying , Yuan Xin

Background: Childhood obesity has been a worrisome public health issues today. Recent studies conducted in adult populations and animals have suggested beneficial effects of probiotics on obesity, while, the experience is limited in the pediatric age group and the results are conflict.Object: The primary objective was to determine the effect of Probiotics consumption on weight change. The secondary objective was to deter...

hrp0092p1-224 | Growth and Syndromes (to include Turner Syndrome) (1) | ESPE2019

The Efficacy and Adverse Reactions of the Letrozole or Gonadotropin Releasing Hormone Analog Combined with Recombinant Human Growth Hormone in Short Pubertal Boys

Chen Ruimin , Zhang Ying , Chen Shijun , Yang Xiaohong , Yuan Xin

Objective: To explore the therapeutic effects and adverse reactions of a combination of letrozole or Gonadotropin releasing hormone analog (GnRHa) and recombinant human growth hormone (rhGH), compared with rhGH alone, in pubertal short boys.Methods: Sixty-four pubertal short boys were divided into three groups, one group were treated with rhGH (rhGH group, n=21), one group were treated with the combination o...

hrp0092p3-208 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

The Early Predictors of Serum IGF-1, DHEAS, AMH and BMP-6 in Rapidly Progressive Puberty Girls

Chen LinQi , Zhang Dandan , Wang Xiaoyan , Xie Rongrong , Wu Haiying

Objective: To investigate the early predictors of serum IGF-1, DHEAS, AMH and BMP-6 in rapidly progressive puberty girls.Methods: 750 cases of central precocious puberty(CPP), early puberty(EP) and rapidly progressive puberty(RPP) in Children's hospital of Soochow university were recruited from August 2017 to December 2018. After follow-up six months to one year, 138 girls were divided into CPP(n=32), EP...

hrp0092p3-272 | Late Breaking Abstracts | ESPE2019

The Effect of Aromatase Inhibitors on Treating Adolescent Boys with Short Stature: A Meta-Analysis of Randomized Controlled Trials

Liu Shufang , Zhou Bo , Zhang Zhixin , Niu Wenquan

Objectives: Recently, aromatase inhibitors are increasingly prescribed as an alternative off-label therapy for short stature in boys, yet its efficiency is controversial. This study aimed to evaluate the effect of aromatase inhibitors on the treatment of short statured boys in adolescence by a comprehensive meta-analysis of published randomized controlled trials.Methods: Literature search, quality assessment and data ext...

hrp0089p1-p062 | Diabetes & Insulin P1 | ESPE2018

Establishment of Iron Overload Insulin Cell Model and the Effect Induced by Iron Overload on Oxidative Stress

Zhang Lina , Liang Liyang , Meng Zhe , Hou Lele , Liu Zulin

Objective: To establish INS-1 cell iron overload model, and study the effect on proliferation, insulin-secretion and oxidative stress change.Methods: INS-1 cells were cultured in either normal or high glucose medium. Both groups were treated with different concentrations of (5, 10, 20, 40, 80 μmol/l respectively) of ferric ammonium citrate (FAC). Number and state of the cells were detected by trypan blue staining. Labile iron pool (LIP) were calcula...

hrp0086rfc15.5 | Late Breaking | ESPE2016

Effect of Melatonin on Proliferation and Differentiation of Human Dental Pulp Cells

He Hongwen , Liu Qin , Huang Fang , Zhang Fuping

Background: Melatonin is known to regulate a variety of biological processes. The investigation and application of melatonin in oral development have got a lot of attention. The study was performed to investigate the effects of melatonin on development of human dentin formation.Objective and hypotheses: To investigate the role of melatonin in proliferation and differentiation of human dental pulp cells(hDPCs).Method: HDPCs were obt...

hrp0086p2-p271 | Diabetes P2 | ESPE2016

Abnormal Glucose Level in Patients with Thalassemia Major

Lao Wenqin , Liang Liyang , Ou Hui , Meng Zhe , Zhang Lina

Background: Abnormalities in glucose homeostasis are fairly common complications in thalassemia major (TM) patients. This study aimed at determining the incidence of diabetes mellitus (DM) and studying the potential factors responsible for secondary DM of TM patients.Objective and hypotheses: A total of 54 (33 male) transfusion-dependent TM patients were in the ‘TM group ’; 25 age- and gender-matched healthy children were recruited as the &#145...

hrp0086p2-p797 | Pituitary and Neuroendocrinology P2 | ESPE2016

Report Two Cases of Dopa-Responsive Dystonia

Zhuannan Jiang , Liyang Liang , Zhe Meng , Lina Zhang , Lele Hou

Background: Dopa-responsive dystonia is a genetic disease that rarely reported in domestic and foreign. Its clinical characteristics is so complex and diverse that it is easy to lead to misdiagnosis and delayed treatment. However, early diagnosis and timely and appropriate treatment can completely improve symptoms. Fortunately, now we can take advantage of gene sequencing to diagnose this rare disease.Objective and hypotheses: Understand the research pro...

hrp0082p1-d1-67 | Diabetes | ESPE2014

Protective Effects of Combined Intervention with Adenovirus Vector Mediated il10 and igf1 Genes on Endogenous Islet β Cells in Nonobese Diabetes Mice with Onset of Type 1 Diabetes Mellitus

Li Tang , Zhang Lijuan , Chen Yanyan , Li Cheng , Lin Xiaojie

Introduction: To investigate the protective effects of combined intervention with adenovirus vector mediated interleukin 10 (IL10) and IGF1 genes on islet β cells in nonobese diabetes (NOD) mice with type 1 diabetes mellitus (T1D) at early stage.Methods: Twenty-four female NOD mice at onset of diabetes and aged 17–20 weeks old were randomly divided into four groups. Mouse 1, 2, and 3 groups were i.p. injected 0.1 ml of Ad-mIGF1, Ad-mIL10, and c...