ESPE Abstracts

Background: The theory of ‘Metabolically healthy obese individuals’ is become very popular in researchers across the world. Nevertheless, obese persons are at increased risk for adverse long-term outcomes compared with metabolically healthy normal-weight individuals.Objective: To determine the obesity-related cardiovascular comorbidities in metabolically healthy obese adolescents comparatively to lean and metabolically unhealthy ones.<p cla...

Background: Epidemiologic studies have shown strong associations between high carotenoids levels and reduced risk of developing various forms of cancer, cardiovascular system diseases, etc.Objective and hypotheses: Carotenoids are hydrophobic substances and are contained in blood in lipoprotein particles. Their conformation depends on their molecular environment. By evaluating the conformation of carotenoids we can obtain various information about the li...

Background: The effects of recombinant GH therapy on development of oxidative stress and insulin resistance in girls with Turner syndrome (TS) were observed.Objective and hypotheses: The aim of this study is to examine the longitudinal relationships of oxidative stress markers with the development of insulin resistance during GH treatment in girls with TS.Method: Ten prepubertal girls (aged 12–14 years; median 13.0 years) with...

The main pitfall of weight management programs is effective and safe fitness regimen choice. According to HELENA Study (2013) physical activity readiness is negatively correlated with markers of insulin resistance (IR) and central adiposity in adolescent population. Meanwhile, very little is known about cardiorespiratory fitness effectiveness in relation to hepatic, peripheral and whole body insulin sensitivity (IS).Methods: 64 adolescents aged 13.56+2.4...

Background: Obesity epidemic is associated with diabetes and it’s complications at young age. Meanwhile, there is no recommendation concerning stratification as a risky for the overweight without dysglycemia by WHO criteria.Objective and hypotheses: Insulin response during OGTT might be dependent on BMI and can reflect preclinical stage of dysglycemiaMethod: 72 otherwise healthy adolescents aged 13.56±2.47 y.o. were exami...

Background: Exercise performance is dependent on glucose supply as fuel to working muscles.Objective and hypotheses: We hypothesised that postprandial insulin secretion impacts exercise induced glucose and insulin response.Method: 27 sedentary obese adolescent males aged 15.31+1.33 were examined. Standard 2 h oral glucose tolerance test (OGTT) with further calculation AUC for glucose and insulin for increments: 0–30 m...

Background: There is a high incidence of acute cardiovascular events in obese subjects.Objective and hypotheses: We hypothesised that exercise tolerance is different in metabolically healthy (MHO) and metabolically unhealthy (MUO) obese adolescents.Method: 45 obese adolescents aged 10–17 (23 males and 22 females) were examined with an anthropometry, fasting blood glucose, insulin and lipids. IDF criteria were used for grouping...

Background: Childhood obesity is a serious medical condition that may well be prevented by the life style modification. Therefore school-age children awareness of the problem is crucial for the educational programs.Subjects Methods: This work is a part of the complex project "Assessment of the current nutritional status, nutrition-related health problems in school-age children in Ukraine". 392 school-age children...

Introduction: About 20 thousands of new cases of obesity (Ob) are first registered in children and adolescents in Ukraine annually (morbidity 2.72/1000, prevalence 13.50/1000 of the corresponding population on 01.01.2016). Adolescent Ob shows catastrophic rise (prevalence 8.9/1000 in 2001 vs 28.3/1000 in 2015). Completely unclear the role of Ghr in the etiopathogenesis of obesity in adolescents.Methodology: A total of 39 obese children with HD (14 boys, ...

Actuality: Standard methods for determining the compensation of the disease don't always reliably reflect the level of the glycemic control of the patient, which leads to decompensation diabetes and reduce the quality and duration of life for patients. Evaluation of glycemic variability indices allows the physicians to predict the risk of developing life-threatening conditions and compensate the diabetesAim: To condu...