hrp0082p2-d1-451 | Growth | ESPE2014

Eleven Years of Letrozole Treatment in a Child with 11-β Hydroxylase Deficiency: Effect on Bone Age and Height Prognosis

Bereket Abdullah , Atay Zeynep , Guran Tulay , Haliloglu Belma , Abali Saygin , Bas Serpil , Turan Serap

Background: Aromatase inhibitors (AI) are being used in clinical trials in children related to peripheral precocious puberty, and idiopathic short stature to improve height prognosis.Case report: A 2 11/12 year-old boy was referred to our center for evaluation of penile enlargement and pubic hair development. Physical examination revealed a well-developed muscular boy with a body weight of 22 kg (>97p), height of 110.1 cm (>97p), with ...

hrp0082p2-d1-519 | Pituitary | ESPE2014

Hyperthyroidism Due to TSH Secreting Pituitary Adenoma in a 7-Year-Old Boy

Abali Saygin , Atay Zeynep , Haliloglu Belma , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Pituitary adenomas in childhood are 2–6% of all surgically treated pituitary adenomas at all ages. It has been estimated that TSH secretion is rare (<1% of all pituitary adenomas). Therefore, TSH secreting adenoma is very rare in childhood. Here we present the youngest patient with TSH secreting adenoma.Case: A 7-year-old boy was referred to our clinic with thyroid dysfunction by the psychiatry clinic, during his evaluation of hypera...

hrp0082p2-d1-595 | Thyroid | ESPE2014

Papillary Thyroid Cancer with Diffuse Pulmonary Metastasis: How to Manage?

Bas Serpil , Abali Saygin , Gokdemir Yasemin , Haliloglu Belma , Atay Zeynep , Karadag Bulent , Bereket Abdullah , Turan Serap

Background: Papillary thyroid cancer (PTC) is the most common endocrine malignancy in children. PTC shows more aggressive progress in children than in adults in respect to local and distant metastases. Here we presented a PTC case with primary pulmonary symptoms and pulmonary metastasis.Case: A 15.5-year-old male patient presented to the clinics with cyanosis and respiratory difficulty for the last 2 years. He had dyspnea, central cyanosis, clubbing, and...

hrp0082p3-d2-779 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Younger Age and BMI >3SD are Risk Factors for Mortality in Children with Hypothalamic Obesity

Haliloglu Belma , Turan Serap , Atay Zeynep , Guran Tulay , Abali Saygin , Bas Serpil , Bereket Abdullah

Background: Hypothalamic obesity is the most flagitious endocrinologic problem following surgical intervention for childhood brain tumors. Thus, recognition of this condition and identification of risk factors for mortality is important.Objective and hypotheses: In this study, we have shared our single center experience in obesity-related mortality in children with hypothalamic obesity.Method: We retrospectively analyzed 20 patient...

hrp0082p3-d1-930 | Puberty and Neuroendocrinology | ESPE2014

Final Height in Girls with Idiopathic Central Precocious Puberty Treated with GNRH Analog: Comparison with Untreated Controls

Atay Zeynep , Abali Saygin , Guran Tulay , Haliloglu Belma , Bas Serpil , Turan Serap , Bereket Abdullah

Background: Studies evaluating the gain in final height in patients with idiopathic central precocious puberty (ICPP) report variable outcomes and mostly lack comparison with untreated controls.Objective and hypotheses: To compare the final height of ICPP patients treated with GnRH analog with and untreated control group.Method: 48 girls with ICPP treated with GnRH analog and 52 untreated girls with ICCP (due to late referral or re...

hrp0084p2-274 | Diabetes | ESPE2015

Friedreich’s Ataxia Presenting with Diabetes Mellitus in an Adolescent

Bas Serpil , Abali Saygin , Atay Zeynep , Gurbanov Ziya , Turkdogan Dilsad , Turan Serap , Bereket Abdullah

Background: FriedreichÂ’s ataxia (FA) is an autosomal recessive neurodegenerative disorder characterised by progressive ataxia with limb muscle weakness, absent lower limb reflexes, extensor plantar responses, dysarthria, decreased vibratory sense and proprioception. The most common molecular abnormality is a GAA trinucleotide repeat expansion in intron 1 of the frataxin (FXN) gene. Patients with FA are at risk of getting increased blood sugar levels, or ...

hrp0084p2-559 | Thyroid | ESPE2015

Central or Primary Hypothyroidism? How to Differentiate in Patients with Low T4 but Mildly Elevated TSH Levels

Turan Serap , Gurbanov Ziya , Bas Serpil , Abali Saygin , Atay Zeynep , Bereket Abdullah

Background: Central hypothyroidism (CH) is caused by TSH and/or TRH deficiency leading to hypothyroxinemia with low, normal or mildly elevated TSH levels. Differentiation of CH with mildly elevated TSH levels from primary hypothyroidism (PH) can be difficult. However, this differentiation has important clinical implications (i.e. cortisol replacement before L-thyroxine).Objective and hypotheses: In this study, we constructed a nomogram all...

hrp0084p3-831 | Fat | ESPE2015

Evaluation of Renal Functions in Obese Children and Adolescents with Cystatin-C and Creatinin Based GFR: is Increasing GFR Reflected Hyperfiltration and Possible Renal Damage in Future?

Salman Dilsah Onerli , Siklar Zeynep , Ilarslan Nisa Eda Cullas , Kocaay Pinar , Ozcakar Birsin , Berberoglu Merih

Introduction: There is a growing interest in the relationship between obesity and renal damage. Chronic kidney disease is accepted as an important complication of obesity in adulthood. However, information on association between childhood obesity and renal functions is limited. In this study, It is aimed to investigate the renal functions in obese children and adolescents.Patients and methods: We enrolled 107 obese children and adolescents as a study gro...

hrp0084p3-969 | GH &amp; IGF | ESPE2015

Evaluating First Year Response and Final Height to Growth Hormone Treatment in Growth Hormone Deficiency Based on Peak GH Levels on Testing

Abali Saygin , Bas Serpil , Akbarzade Azad , Atay Zeynep , Haliloglu Belma , Guran Tulay , Turan Serap , Bereket Abdullah

Background: Diagnosis of GH deficiency (GHD) is a complicated issue especially in isolated GH deficiency. Auxological evaluation, IGFI, IGFBP3 levels and GH response to provocative testing are all considered in the diagnosis. However, cut-off values for GH levels at stimulation tests are controversial. We aimed to evaluate the response to rhGH treatment in patients with different GH peak levels in stimulation test.Objective: We aimed to evaluate the resp...

hrp0084p3-975 | GH &amp; IGF | ESPE2015

Factors Effecting Response to Growth Hormone Treatment in Children with Turner Syndrome

Bas Serpil , Abali Saygin , Atay Zeynep , Haliloglu Belma , Gurbanov Ziya , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Short stature is the most common presenting symptom in Turner Syndrome (TS). GH treatment helps alleviating short stature in TS, although response to treatment varies significantly.Objective and hypotheses: We aimed to evaluate the response to GH treatment and factors affecting this response in children with TS.Method: Forty-nine patients with TS diagnosed by cytogenetic analysis and who had been followed minimum of 1-y...