hrp0097rfc5.3 | Diabetes and insulin 1 | ESPE2023

3 Screen ICA ELISA–A new tool to identify pre-clinical diabetes in first-degree relatives of patients with type 1 diabetes (pre-d1abetes study)

Bossowski Artur , Noiszewska Klaudyna , Polkowska Agnieszka , Zasim Aneta , Jamiolkowska Milena , Mysliwiec Malgorzata , Szadkowska Agnieszka , Mazur Artur , Jarosz-Chobot Przemyslawa , Szypowska Agnieszka , Chobot Agata , Nazim Joanna , Zubkiewicz Agnieszka , Ben-Skowronek Iwona , Niechcial Elzbieta , Walczak Mieczyslaw , Jozwa Anita , Mincewicz-Wysocka Marta , Robak-Kotna Katarzyna , Chen Shu , Furmaniak Jadwiga , Smith Bernard

Introduction: Overt clinical symptoms of type 1 diabetes (T1D) are often preceded by a pre-clinical stage of varying duration. Diagnosis of the pre-clinical stage is difficult and is based on the presence of specific islet autoantibodies in the subject's blood. Objectives: Apparently healthy first-degree relatives of patients with T1D were tested using the 3 Screen ICAELISA (RSR Ltd) for combined testing for autoantibodies to GAD65 (glutamic acid decarbox...

hrp0097p1-436 | Diabetes and Insulin | ESPE2023

Should the diagnostic criteria of childhood obesity depend on the nutritional status of national pediatric population? A lesson form assessment of Ukrainian children with type 1 diabetes in Poland after Russian aggression against Ukraine.

Smyczyńska Joanna , Suchowiński Michał , Kopeć Kacper , Seliga Przemysław , Olejniczak Aleksandra , Szadkowska Agnieszka

Introduction: Childhood overnutrition is a global challenge of public health. Both WHO and different countries have prepared BMI charts for pediatric population. Proper assessment of nutritional status is particularly important in children with type 1 diabetes (DM1). Due to Russian aggression, some Ukrainians with DM1 have to continue treatment in Poland.Aim: to compare HbA1 concentrations and the incidence of overnutrit...

hrp0098fc3.3 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2024

Analysis of clinical factors affecting retinal ganglion cell complex thickness reduction in patients with childhood onset craniopharyngioma.

Bogusz-Wójcik Agnieszka , Rakusiewicz Klaudia , Tutka Aleksandra , Hautz Wojciech , Jaworski Maciej , Moszczyńska Elżbieta

Background: Visual impairment is a critical component of aftercare in survivors of childhood onset craniopharyngioma (CP). This study aims to evaluate retinal ganglion cell complex thickness (GCC) and correlation with clinical parameters in patients with CP using optical coherence tomography (OCT).Methods: Sixty eyes of 37 patients with childhood onset craniopharyngioma and 90 eyes of 45 age and sex-matched healthy volun...

hrp0098p1-72 | Multisystem Endocrinology | ESPE2024

Serum nesfatin-1 and GLP-1 concentrations in adolescent patients with anorexia nervosa/obesity.

Blaska Małgorzata , Zachurzok Agnieszka , Gołąb-Jenerał Katarzyna , Ziora Katarzyna

Introduction: Anorexia nervosa (AN) is a psychiatric disorder affecting mainly adolescents and young women, characterized by a restriction of energy intake leading to malnutrition, serious medical complications and high mortality. Until now the etiology of AN remains unknown and seems to be multifactorial. Patients with AN develop endocrine disorders related to disturbances of energy metabolism. Nesfatin-1 and glucagon-like peptide-1 (GLP-1) are involved in th...

hrp0098p1-188 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Childhood-onset craniopharyngioma: 26 years of experience at Children's Memorial Health Institute (CMHI)

Moszczyńska Elżbieta , Bogusz-Wójcik Agnieszka , Tutka Aleksandra , Baszyńska-Wilk Marta

Introduction: Childhood onset craniopharyngioma (CP) is a rare, low-grade (WHO I) embryonic malformation arising from remnants of the craniopharyngeal duct in the sellar and parasellar regions.Methods: This retrospective study included 167 children (53% boys, 47% girls) diagnosed with CP at the CMHI, Warsaw, Poland, from 1998 to 2024. We evaluated anthropometric data, hormonal test results pre- and post-surgery, brain ma...

hrp0098p3-115 | Fat, Metabolism and Obesity | ESPE2024

Bariatric surgery in adolescents - one center experience

Szeliga Kamila , Pietrusik Agnieszka , Krakowczyk Dominika , Basek Dariusz , Koszutski Tomasz , Gawlik-Starzyk Aneta

Background: Obesity is one of these chronic diseases that makes difficulties in achieving a therapeutic effect and maintaining the obtained effect both in respect of lost kilograms and preventing from the development of its associated diseases. The children's population has the primacy of development of this disease. Surgical treatment is an alternative and in many cases the only right solution to ineffective conservative treatment. It is one of the stage...

hrp0098p1-255 | Growth and Syndromes 3 | ESPE2024

Health and life risks in children with achondroplasia – multicenter study.

Wrobel Wiktoria , Bossowski Artur , Cichon-Kotek Monika , Erazmus Michal , Gawlik-Starzyk Aneta , Mysliwiec Malgorzata , Petriczko Elzbieta , Pietrusik Agnieszka , Pyrzak Beata , Stawerska Renata , Smigiel Robert , Walczak Mieczyslaw , Wojcik Malgorzata , Zachurzok Agnieszka , Ben-Skowronek Iwona

Background: Achondroplasia is a genetic disorder that belongs to a large group of skeletal dysplasias that is caused by a missense mutation in the gene encoding FGFR-3 resulting in its constitutive upregulating. This interferes with the receptor's tyrosine kinase domain causing inhibition of cartilage tissue cells and the formation of abnormalities in the bone growth plate leading to defective skeletal development and a disproportionately short stature wi...

hrp0095p2-84 | Diabetes and Insulin | ESPE2022

Assessment of serum concetrations of decorin, vaspin and kallistatin in children with type 1 diabetes

Polkowska Agnieszka , Bossowski Filip , Żelazowska-Rutkowska Beata , Marcinkiewicz Katarzyna , Nesterowicz Miłosz , Leoniuk Rafał , Bossowski Artur

The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study included 88 ch...

hrp0092p3-280 | Late Breaking Abstracts | ESPE2019

Short, but Daily and Controlled Physical Activity of Children with Obesity has a Positive Effect on The Irisin and Chemerin Levels

Wójcik Małgorzata , Kozioł-Kozakowska Agnieszka , Januś Dominika , Furtak Aleksandra , Starzyk Jerzy

Therapeutic interventions in obesity in addition to the weight loss, seek to improve the profile of cytokines. It is believed that physical activity, even in the absence of significant weight loss, may favorably increase the concentration of irisin and decrease the concentration of chemerin. The aim of the study was to compare the impact of a standard lifestyle intervention (SI) with an intense intervention (II) including controlled increase of daily physical ...

hrp0089p1-p059 | Diabetes & Insulin P1 | ESPE2018

Impact of Diabetes During Pregnancy in Women Affected with GCK-MODY on Neonatal Health Outcome

Brandt Agnieszka , Wołoszyn-Durkiewicz Anna , Buraczewska Marta , Kopacz-Petranyuk Katarzyna , Myśliwiec Małgorzata

Introduction: Gestational diabetes is one of the most common medical disorders and may cause numerous maternal and fetal complications. It constitutes one of the most frequent pregnancy health problems and may cause wide range of complications such as: preterm births, congenital defects, sacral agenesis, hypertrophic cardiomyopathy, metabolic changes and macrosomia in neonates. Therefore, early detection and implementation of guideline-based screening tests, are crucial. One o...