hrp0098p3-61 | Diabetes and Insulin | ESPE2024

Case report neonatal DM

Wafeeq Rasha

• Kamelia, 10 months, known case of neonatal diabetes diagnosed at 5 months of age.• Presented to our pediatric ICU in Mansoura Health Insurance Hospital by hyperglycemia associated with high grade fever.• She was diagnosed diabetic at age of 5 months associated with hypothyroidism at initial diagnosis in Mansoura university children hospital.• Discharged on NPH 3 times daily on 0.7 units/...

hrp0082p2-d2-581 | Sex Development (1) | ESPE2014

Rare Disease Registries: Perception of Parents and Young People

Jayasena Arundathi , Muscarella Miriam , Ahmed Faisal

Background: Rare-disease registries are considered to be the key for improving patient care through research and audit. In the field of paediatric endocrinology, the views of parents and affected young people about such registries are unclear.Objective: To conduct a survey to understand the views of parents and young people with rare conditions.Method: A structured questionnaire was completed by two groups of clinic attendees, thos...

hrp0097p1-444 | Diabetes and Insulin | ESPE2023

From human insulin to insulin analogues: what impact on the BMI of children with type 1 diabetes?

Marzouk Asma , Laajili Mariem , Zouari Noura , Bouguila Jihene , Bouaziz ASma

Introduction:Despite the widely proven value of insulin analogs in the treatment of children with type 1 diabetes (T1D), pediatric studies of Increased weight gain in T1D are complicated by the age-dependency and gender-dependency of BMI, and also by a trend towards obesity in the general population.Objective: to assess the impact of switching from Humain Insulin (HI) to insulin analogues on the BMI of children with T1D....

hrp0095lb25 | Late Breaking | ESPE2022

Challenges of Gender Assignment in Disorder of Sex Development (DSD) in Developing Countries

Aftab Sommayya , Manzoor Jaida , Shaheen Tahir , Hira Noore , Talat Nabila , Bilal Muahmmad , Iqbal Nasir Sajid , Tahir Warda , Usama Aziz Muhammad , Bari Attia , Ullah Ehsan , Mansoor Bugvi Saima , Bashir Shabnam , Akber Maida

Background: Gender assignment in children with disorder of sex development (DSD) is a key step in their management and needs detailed assessment. In developing countries, children with DSD are often presented late, due to lack of awareness and social stigmatization, which makes management more challenging.Methodology: Retrospective review of complex DSD cases (karyotyping different from current sex of rearing), presented...

hrp0097p2-133 | Fat, Metabolism and Obesity | ESPE2023

Integrated care for childhood obesity within the medical and municipal domain

van Mil Edgar , Koetsier Leandra , Seidell Jaap , Sijben Marian , Stroo Judith , van der Velde Marian , Halberstadt Jutka

Childhood obesity is a chronic disease with detrimental effects on health and wellbeing. Treatment was traditionally focused on reducing caloric intake and increasing energy expenditure. However, considering the global increase in prevalence in obesity, especially in the paediatric age range, this approach is insufficient and transition to new initiatives is needed. Obesity is a complex disease resulting from the interaction of multiple underlying factors, including personal c...

hrp0086p2-p841 | Syndromes: Mechanisms and Management P2 | ESPE2016

Safety and Efficacy of Growth Hormone (GH) in Combination with the Gonadotrophin Releasing Hormone Agonist Leuprorelin in Pubertal Children with Idiopathic Short Stature

Benabbad Imane , Tauber Maite , Rosilio Myriam , Paris Emmanuel , Berggren Lovisa , Patel Hiren , Carel Jean-Claude

Background: Due to delays in diagnosis of Idiopathic Short Stature (ISS), puberty has often started when Growth Hormone (GH) is initiated.Objective and hypotheses: To compare GH+leuprorelin (GH+L) with GH alone in patients with ISS and at Tanner puberty stage 2 or 3. We hypothesised that co-administration of GH+L for 2–3 years would delay puberty, prolong GH efficacy and increase adult height.Method: A phase 3, randomised, ope...

hrp0084p3-832 | Fat | ESPE2015

The French Experience in Bariatric Surgery ‘Laparoscopic Adjustable Gastric Banding’ in Adolescence

Dabbas Myriam , Khen-Dunlop Naziha , De Filippo Jean Paul , Bougneres Pierre , Goulet Olivier , Revillon Yann

Background: Because the success rate of lifestyle interventions is modest in severely obese adolescents, surgical treatments are now proposed. Laparoscopic adjustable gastric banding (LAGB) represents an attractive treatment with minimal morbidity and reversible procedure.Method: All adolescents were included in prospective longitudinal assessment and entirely managed by a pediatric team. Surgery was proposed only after at least 1-year lifestyle interven...

hrp0098p2-259 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

Fostering Resilience: Exploring Family Support Groups for Girls with Turner Syndrome - A Pilot Study

Shemesh-Iron Moran , Safrai Myriam , Shapira Moran , Meirow Dror , Gruber Noah

Introduction: Parents of girls with Turner syndrome (TS) are coping with various challenges associated with caring for a child with a chronic disease.Aims: Explore the logic and importance of group support for parents of girls with TS.Methods: Group support sessions for parents of girls with TS were divided into meetings regarding psychological aspects, medical aspects, and social ...

hrp0098rfc6.2 | Fat, Metabolism and Obesity 1 | ESPE2024

Genetic Diagnostic Yield of Obesity

Künzel Robert , Faust Helene , Blüher Matthias , Wenzel Eric , Abou Jamra Rami , Jasaszwili Mariami , Kirstein Anna , Kobelt Albrecht , Körner Antje , Lemke Johannes , Stein Robert , Garten Antje , Le Duc Diana

Background/Objectives: Obesity poses a major public health concern. Although studies estimate that the heritability of BMI lies around 40–50%, the underlying genetics are still poorly understood. In monogenic obesity, solitary genetic variations significantly increase obesity risk. We therefore aim to (1) report the diagnostic yield of monogenic obesity using exome-wide data in a large cohort of over 500 individuals and aim to (2) improve future diagnost...

hrp0095p2-120 | Fat, Metabolism and Obesity | ESPE2022

Evaluation of Thyroid Function among children and adolescents with obesity

Nourbakhsh Mona , Ramezani Nastaran , Nourbakhsh Mitra , Razzaghy Azar Maryam

Introduction: Obesity is a rapidly growing health problem, with increasing worldwide prevalence. Obesity is accompanied by numerous metabolic and endocrine dysregulation. Thyroid dysfunction is one of the many metabolic aberrations that are associated with obesity. Thyroid dysfunction can be related to obesity, insulin resistance, and dyslipidemia. We aimed to study the thyroid function in children and adolescents with obesity and the metabolic parameters....