hrp0086rfc5.1 | Management of Disorders of Insulin Secretion | ESPE2016

Adiponectin and Leptin in Children with Type 1 Diabetes for 3-5 years with or without Residual β cell Function

Birkebaek Niels H , Sorensen Jesper S , Kristensn Kurt , Pociot Flemming , Frystyk Jan

Background: Studies in adults with type 1 diabetes (T1D) have indicated that adiponectin is negatively associated and leptin positively associated with measures of a residual beta cell function (RBF).Objective and hypotheses: To compare serum adiponectin and leptin levels and their ratio in children with T1D for 3–5 years with and without RBF and in healthy children.Method: We included 342 children (173 females) with T1D, here...

hrp0086p2-p574 | Perinatal Endocrinology P2 | ESPE2016

Use of a Cord Blood F-Dex Monocyte Binding Assay to Study the Glucocorticoid Sensitivity in Premature Neonates

Madubuko Adaora , Giuliano Michael , Al-Khan Abdulla , Alvarez Manuel , Alvarez-Perez Jesus , Balboul Sarah , Aisenberg Javier , Ghanny Steven

Background: Glucocorticoids play an important role in the developing fetus; the most important of which is lung maturation by increasing surfactant production and release. Glucocorticoid receptor (GR) functioning changes throughout the fetal period, especially during the transition to extrauterine life. Given the importance of glucocorticoids in lung development and functioning, studying glucocorticoid sensitivity (GS) in this population would be helpful, especially in the pre...

hrp0086p1-p608 | Growth P1 | ESPE2016

Pubertal Height Gain in Females with Isolated Growth Hormone Deficiency Treated with rhGH Alone or in Combination with GnRHan

Voutetakis Antonis , Chiotis Dimitris , Gryparis Alexandros , Kanaka-Gantenbein Christina , Dacou-Voutetakis Catherine

Background: A significant component of total linear growth is height gain achieved after the initiation of puberty. Children with Isolated GH Deficiency (IGHD) frequently come for evaluation around the peripubertal stage. Therefore, increasing pubertal height gain in IGHD children entering puberty with a relatively low height is important. Researchers have tried to assess effectiveness of treatment in such patients based on various key measurements and a variety of end-points....

hrp0086p1-p620 | Growth P1 | ESPE2016

Efficacy of Growth Hormone Treatment in Patients with Type 1 Diabetes Mellitus and Growth Hormone Deficiency

Bonfig Walter , Lindberg Anders , Cutfield Wayne , Dunger David , Camacho-Hubner Cecilia , Holl Reinhard W

Background: The combination of type 1 diabetes mellitus (T1DM) and GH deficiency is uncommon. In a previous study (1) we found that in children with T1DM and GHD with adequate adaptation of insulin dosage, the metabolic control of T1DM did not worsen during GH treatment. However, decreased catch-up growth was observed and no data on GH dose was available.Objective: To analyse first year treatment growth response and GH dosage in prepubertal patients with...

hrp0086p2-p855 | Syndromes: Mechanisms and Management P2 | ESPE2016

The Usefulness of Magnetic Resonance Imaging of the Heart and Aorta in the Diagnostic Work-up in Girls with Turner Syndrome

Obara-Moszynska Monika , Rozmiarek Szymon , Lanocha Magdalena , Kociemba Anna , Rabska-Pietrzak Barbara , Janus Magdalena , Siniawski Andrzej , Mrozinski Bartlomiej , Niedziela Marek , Pyda Malgorzata

Background: Congenital heart defects are found in 50% of girls with Turner syndrome (TS). The evaluation of cardiovascular system is an important element in the diagnostic work-up of TS and is of particular significance of cardiologic monitoring, safety aspects of rGH treatment and any pregnancy planning.Objective and hypotheses: Assess the cardiovascular system in TS girls with magnetic resonance imaging of the heart and aorta (CMR and angioMR).<p c...

hrp0086p1-p903 | Thyroid P1 | ESPE2016

HABP2 as Genetic Susceptibility Factor for Familial Differentiated Thyroid Carcinoma

de Randamie Rajdee , Martos Gabriel , Lumbreras Cesar , Regojo Rita Maria , Mendiola Marta , Argente Jesus , Moreno Jose Carlos

Background: HABP2 is an extra-cellular matrix protein involved in cell proliferation. Recently, HABP2 was proposed as responsible for the familial clustering of Differentiated Thyroid Carcinoma (FDTC). However, its involvement was questioned by subsequent studies revealing high prevalence HAPB2 polymorphisms (SNPs) in the general population, leaving its pathogenic role uncertain.Objective and hypotheses: To identify genetic HABP2</e...

hrp0086p1-p930 | Thyroid P1 | ESPE2016

Seasonality of Month of Birth in Children and Adolescents with Hashimoto Thyroiditis

Kyrgios Ioannis , Giza Styliani , Kotanidou Eleni , Maggana Ioanna , Galli-Tsinopoulou Assimina

Background: A number of studies have previously described seasonality of birth in children with type 1 diabetes, thus suggesting that the autoimmune process may begin during fetal development. However, there is a lack of data regarding autoimmune thyroid disease in childhood.Objective and hypotheses: The aim of this study was to analyse the seasonal birth month pattern in young patients with Hashimoto thyroiditis and compare it with that of youth healthy...

hrp0082p2-d2-329 | Diabetes (1) | ESPE2014

Lipid Profile is Related to Androgen Level in Adolescent Girls with Type 1 Diabetes Mellitus

Zachurzok Agnieszka , Deja Grazyna , Gawlik Aneta , Drosdzol-Cop Agnieszka , Malecka-Tendera Ewa

Background: The mechanisms underlying dyslipidaemia in the context of polycystic ovary syndrome may include not only metabolic aberrations but also hormonal factors, in particular hyperandrogenaemia.Objective and hypotheses: The aim of the study was to establish whether dyslipidaemia and metabolic control disturbances are related to hyperandrogenaemia in adolescent girls with type 1 diabetes mellitus (T1DM).Method: We studied 54 gi...

hrp0082p3-d1-926 | Puberty and Neuroendocrinology | ESPE2014

The Significance of GnRH Stimulation Test, Leptin, and Pelvic Ultrasound Findings for Differentiating Idiopathic Central Precocious Puberty from Premature Telarche

Ersoy Betul , Yazici Pinar , Onur Ece , Ozkol Mine

Background: We aimed to investigate the differences of serum leptin, gonadotropin hormones levels on GnRH stimulation test, and pelvic ultrasound (US) findings between girls with idiopathic central precocious puberty (ICPP) and premature telarche (PT). Additionally, we aimed to determine correlations between leptin and other parameters.Method: Thirty-nine girls who had the breast budding before the age of 8 years and 19 healthy age-matched pre-pubertal g...

hrp0082p3-d1-976 | Thyroid | ESPE2014

Adiposity and Pubertal Status Effects on Thyroid Function in Overweight Children and Adolescents

Giannakopoulos Aristeidis , Pervanidou Panagiota , Lazopoulou Natalia , Chrousos George , Kanaka-Gantenbein Christina

Background: In recent years, studies have consistently demonstrated higher TSH concentrations in overweight/obese children and adults compared with normal weight individuals, whereas the levels of thyroid hormones in peripheral blood remain within normal range. This euthyroid hyperthyrotropinemia on the background of a worldwide increase in childhood obesity raises the question of whether subjects with this elevated TSH should be treated.Objective and hy...