hrp0086p1-p458 | Fat Metabolism and Obesity P1 | ESPE2016

Association of miR-34a and mir-149 with Obesity and Insulin Resistance in Obese Children and Adolescents

Nourbakhsh Mitra , Ahmadpour Fatemeh , Khaghani Shahnaz , Alipour Behnam , Razzaghy Azar Maryam

Background: Obesity is a major public health problem and its rate is increasing worldwide. Obesity accompanies perturbations in metabolism, conferring substantial excess risk for insulin resistance and Type 2 diabetes. Various genetic and epigenetic factors contribute to the development of obesity. MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolis...

hrp0082p2-d1-268 | Adrenals & HP Axis | ESPE2014

Analysis of Prospective Annual ACTH Stimulation Testing Among Survivors of Intracranial Tumor

Golekoh Marjorie , Mantravadi Manasa , Hornung Lindsey , Khoury Jane , Fouladi Maryam , Rose Susan , Lawson Sarah

Background: ACTH deficiency (ACTHD) is a potentially life-threatening condition observed in many childhood survivors of intracranial. Time from tumor diagnosis and therapy to development of ACTHD cannot be ascertained from previous studies. This lack of knowledge has led to annual surveillance using low-dose ACTH stimulation testing (LDST) for 10–15 years following completion of therapy.Objective and hypotheses: To identify the incidence and timing ...

hrp0082p3-d3-657 | Autoimmune Endocrine Disease | ESPE2014

Is There Any Correlation Between Height and Pediatrics’ Malignancy

Darbandi Bahram , Jafroodi Maryam , Baghersalimi Adel , Koohmanaee Shahin , Hassanzadeh Rad Afagh , Dalili Setila

Background: Recent studies had been demonstrated that raised height could be related with Hodgkin lymphoma (HL). In addition, increased osteo–sarcorma had been indicated in taller individuals and those with earlier pubertal growth spurts. however, some investigators obtained no significant relation between elevated height and childhood malignancy.Objective and hypotheses: We aimed to investigate whether there is any correlation between height and pe...

hrp0084p2-332 | Fat | ESPE2015

SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic Parameters and Insulin Resistance

Nourbakhsh Mitra , Razzaghy-Azar Maryam , Arab Zahra , Pasalar Parvin , Golestani Abolfazl , Larijani Bagher

Background: Sirtuins are NAD+-dependant protein deacetylases that target histones, transcription factors, co-regulators, as well as metabolic enzymes to adapt gene expression and metabolic activity in response to the cellular energy state. SIRT1 and SIRT2 are two important enzymes of sirtuin family. SIRT1 has an important role in glucose metabolism and improves glucose homeostasis. It can also regulate fatty acid oxidation and hepatic cholesterol and bile acid metab...

hrp0084p2-364 | Fat | ESPE2015

Evaluation of Acylated Ghrelin and Obestatin Levels and Ghrelin:Obestatin Ratio in Obesity

Razzaghy-Azar Maryam , Nourbakhsh Mitra , Pourmoteabed Abdolreza , Nourbakhsh Mona , Illbeigi Davoud , Arab Zahra

Background: Ghrelin is 28-amino acid peptide predominantly produced by the stomach and have an orexigenic property as well as potent GH-releasing activity. Acylated ghrelin (AG) is the active form of this hormone. Obestatin is a 23-amino acid peptide, is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake.Objective and hypotheses: To evaluate acylated g...

hrp0084p3-886 | Fat | ESPE2015

Obesity in School Children of Zahedan-Iran; Double Burden of Weight Disorders

Soheilipour Fahimeh , Pourzahabi Zeinab , Lotfi Maryam , Moradi-Lakeh Maziar , Jolfaie Atefeh Ghanbari

Background: Obesity has a permanent effect on children’s health and acts as a major risk factor for chronic diseases. Therefore considering the children’s BMI is a vital parameter at each visit. This study was performed to measure prevalence of obesity and its determinants in school children of Zahedan in Iran; Zahedan is the capital of Sistan-and-Balouchestan province which is known to have the highest prevalence of underweight in Iranian children.<p class="abst...

hrp0094p1-37 | Fat, Metabolism and Obesity A | ESPE2021

The effect of trans-palmitoleic acid on lipid accumulation and the fatty acid synthase gene expression in hepatocytes

Nourbakhsh Mitra , Farokh-Nezhad Ramesh , Razzaghy-Azar Maryam , Sharifi Roya , Yaghmaei Parichehreh , Nourbakhsh Mona ,

Introduction: Obesity is among the most prevalent health problems and is associated with increased risk of various metabolic disorders, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Fatty acids comprise a major part of the lipids and have remarkable effect on cell biology. Trans fatty acids (tFAs) are generally a by-product of manufacturing of fats. However, naturally-produced tFAs that are found in milk and dairy products, are sugge...

hrp0094p2-416 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Ovarian Juvenile Granulosa Cell Tumor in 9-Month-Old female Infant presented with Isosexual Pseudo Puberty: Case Report

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Alyafie Fawzia , Maadheed Maryam AL , Clelland Colin

Background: In infants, less than 1-year JGCT is extremely rare, with very few reported cases in the literature.Case Report: This 9-month old girl, presented with a day history of bloody vaginal secretions, with an increase in breast size bilaterally 2 months before presentation and growth of fine hair in the genital area. She had no skin hyperpigmentation, no skeletal abnormalities, and no dysmorphic features. On examination, the girl had no dysmorphic ...

hrp0094p2-106 | Diabetes and insulin | ESPE2021

Knowledge of the Final Year Medical Students Compared to Interns about the Diagnosis and management of Diabetes Mellitus

Al-Badi Hamid , Al-Sabbari Maryam , Al-Maskari Balsam , Alsaffar Hussain ,

Introduction: Since diabetes mellitus is one of the major non-communicable diseases, therefore it is important taking this subject in some details during the undergraduate medical course, to prepare the students for recognizing the disease and understanding its management. In Sultan Qaboos University, the medical students go through a pre-internship training period, immediately after their final year of clerkship and just before starting their internship.<...

hrp0094p2-145 | Diabetes and insulin | ESPE2021

Dealing with hypoglycaemia during acute DKA management by paediatric residents from Bahrain, Iraq and Saudi Arabia

Alsaffar Hussain , Ali Khadija , Hadi Wasnaa , Foad Ali Maryam , Attia Najya ,

Introduction: During management of Diabetic ketoacidosis (DKA), and after starting the insulin infusion, it is crucial to monitor the blood glucose level frequently. If the glucose level drops quickly or below certain limit when there is still an evidence of ketonemia, it is recommended to add dextrose to the maintenance fluids and continuing the insulin infusion to switch off the ketosis process. However certain measures are required when the glucose continue...