hrp0082p3-d3-913 | Pituitary (1) | ESPE2014

Follow Up for Adult Height of Girl with the Onset of Puberty at 6 or 7 Years Old

Xu Zhuang-Jian , Ma Ya-Ping , Zhao Jin-Ling , Zhang Jian-Mei , Xia Bing-Yang

Background: It is not yet clear whether the adult height (AH) is affected by the onset of puberty at 6 or 7 years old in girl in China.Objective and hypotheses: To evaluate AH in girl with the onset of puberty at 6 or 7 years old.Method: The standard of AH in girl was considered that their bone ages were equal to (or greater than) 15 years old or they were at least 3 years post-menarche. Eighty-two girls with the onset of puberty a...

hrp0084p1-24 | Diabetes | ESPE2015

The Influence of miR-125b in Pancreatic β-Cell Apoptosis

Han Bei , Zhu Ziyang , Gu Wei , Ni Shining , Yang Ruixue , Shi Xing , Yuan Xuewen , Gao Wentao

Background: Type 1 diabetes is characterised by destruction of islet β cell by autoimmune insulitis and islet cell apoptosis. This study analysed the microRNA 125b how to regulate pancreatic β-cells dysfunction, aiming to elucidate the association between miRNA125b and type 1 diabetes.Objective and hypotheses: Recent study indicate miRNA may have role in the development of type 1 diabetes, so this study analyse the miRNA expression profile in t...

hrp0084p1-154 | Miscelleaneous | ESPE2015

Novel Compound Heterozygous BMP1 Variants Associated with Osteogenesis Imperfecta

Yang Aram , Huh Rimm , Kim Jinsup , Cho Sung Yoon , Jin Dong-Kyu

Background: Osteogenesis imperfecta (OI) includes a group of disorders with a susceptibility to bone fractures, the presentation ranging from slightly increased fracture frequency to death in the perinatal period.Objective and hypotheses: Autosomal-dominant inheritance with type I collagen biosynthesis defects is the most common, but many autosomal-recessive genes have been previously reported.Method: Whole-exome sequencing was per...

hrp0084p2-177 | Adrenals | ESPE2015

Analysis the Relationship between Clinical Characteristics and Genotype of Six Cases of Bartter Syndrome and Gitelman Syndrome in Children

Jun Zhang , Qiuli Chen , Song Guo , Ping Yang , Huamei Ma , Yanhong Li , Minlian Du

Background: In developing countries, due to the lack of medical resources, it is necessary to do the preliminary diagnosis of Bartter syndrome and Gitelman syndrome according to the existing clinical data rather than the genetic testing. Is clinical diagnosis consistent with the gene diagnosis?Objective and hypotheses: To summarise the children’s clinical features, furosemide/hydrochlorothiazide loading test and genotype of Bartter syndrome and Gite...

hrp0084p2-287 | Diabetes | ESPE2015

Incidence of Type 1 Diabetes among Korean Children and Adolescents in 2012–2013: Analysis of Data from the Nationwide Registry of Korea

Kim Jae Hyun , Lee Young Ah , Yang Sei Won , Shin Choong Ho

Background: The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents has increased worldwide. However, the epidemiology of T1DM among Korean children has not been reported since 2001.Objective and hypotheses: We therefore investigated the incidence of T1DM in Korean children and adolescents in 2012–2013 and compared it with data from 1995–2000.Method: Data were obtained from the National Health Insuran...

hrp0084p2-450 | Growth | ESPE2015

Pharmacokinetics and Efficacy of a Long-Acting Human GH with Fc Fusion Protein

Kim Sujin , Jin Dong-Kyu , Cho Sungyoon , Huh Rimm , Kim Jinsup , Yang Aram , Kwak Hyunhee

Background: Recombinant human GH (rhGH) therapy requires daily s.c. injections, this inconvenient treatment regimen results to poor compliance of the patient. Thus, to improve patient compliance, long-acting rhGH products including various protein fusion techniques have been in development during past 15 years.Objective and hypotheses: In this study, we describe the pharmacokinetics and efficacy of a novel long-acting GH using Fc fusion protein (rhGH-Fc)...

hrp0084p2-545 | Puberty | ESPE2015

Change of Growth Pattern and Bone Mineral Density in Ovariectomised Female Rats According to Oestrogen Dosage

Kang Byung Ho , Park Mun Suk , Yang You Jung , Lim Sung Jig , Shim Kye Shik

Objective and hypotheses: The purpose was to get the basic data of optimum serum concentration of oestrogen in pubertal growth spurt, minimising the decrease of bone mineral density or acceleration of epiphyseal closure of long bones.Method: i). Fifteen female S.D. rats (4-week aged) were ovariectomised to inhibit their endogenous oestrogen effect and randomly divided into three groups. After 1 week, the group 1 were injected subcutaneousl...

hrp0084p3-783 | DSD | ESPE2015

Impact of Neonatal Exposure to Different Doses of Bisphenol A on the Hypothalamic-Pituitary-Testicle Axis in Male Rat

Chen Lin Qi , Zhou Wen Wen , Yang Fan , Wu Hai Ying , Jin Mei Fang

Background: Male genital abnormalities may be associated with environmental endocrine disruptors.Objective and hypotheses: To observe the hypothalamic kiss-1 gene and the testis androgen acceptor (AR) gene expression level changes and the level of serum luteinizing hormone (LH), follicle stimulating hormone (FSH); testosterone (T) and Inhibin B (INH B) in neonatal rats which exposure to different doses of bisphenol-A (BPA). In order to explore the effect...

hrp0084p3-876 | Fat | ESPE2015

Obesity has a Significant Impact on Hyperandrogenemia Only after Puberty in Korean Girls

Kang Min Jae , Shim Young Suk , Oh Yeon Joung , Hwang Il Tae , Yang Seung

Background: As metabolic complication and polycystic ovarian syndrome due to childhood obesity is rising, the role of hyperandrogenemia (HA) and hyperinsulinism is receiving attention.Objective and hypotheses: The aim of this study was to investigate the presence or absence of obvious HA according to pubertal status and to find potential etiologic determinants of HA in Korean obese girls.Method: We analysed 91 subjects aged 6–...

hrp0084p3-925 | GH & IGF | ESPE2015

Influence of the -202 A/C IGFBP3 Promoter Polymorphism on Individual Variation in Body Height in Korean Girls

Yang Seung , Shim Young Suk , Kang Min Jae , Oh Yeon Joung , Hwang Il Tae

Background: The most common single nucleotide polymorphism in the IGFBP3 promoter region occurs at position -202. This polymorphic variation occurs frequently and may influence GH responsiveness and somatic growth.Objective and hypotheses: This study aimed to assess the effects of IGFBP3 promoter polymorphism on growth in children.Method: Restriction fragment length polymorphism (RFLP)-based genotyping of the -202 single nucleotide...