hrp0082fc10.2 | Programming & Early Endocrinology | ESPE2014

Stk11 Expression in Adipose Tissue Following Fetal Growth Restriction: Relation to Catch-Up Growth and Visceral Fat Mass

Carreras-Badosa Gemma , Remesar Xavier , Prats-Puig Anna , Platero-Gutierrez Estibaliz , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel

Background: STK11 regulates glucose and lipid metabolism. In adult rats, excessive fat deposition and dysfunctional metabolism are related to low STK11 expression in adipose tissue. It is unknown if low STK11 expression in adipose tissue relates also to catch-up growth and fat deposition after intrauterine growth restriction.Objective and Hypotheses: To assess the expression of STK11 in adipose tissue and its relation ...

hrp0082p1-d1-106 | Fat Metabolism & Obesity | ESPE2014

Natural Antibiotics: New Biomarkers of Childhood Obesity

Prats-Puig Anna , Gispert-Sauch Montserrat , Carreras-Badosa Gemma , Diaz-Roldan Ferran , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel

Background: The innate immune system is one of the first lines of host defense against invading pathogens. Pro-inflammatory α-defensins (mainly DEFA1–3) and anti-inflammatory bacterial/permeability-increasing protein (BPI) are antimicrobial peptides predominantly produced by neutrophils which have been recently related to obesity, type 2 diabetes and cardiovascular risk.Objective and hypotheses: The aim of our study was to test whether α-d...

hrp0082p2-d1-365 | Fat Metabolism & Obesity | ESPE2014

Large-Born Infants Switch from an Adipose to a Lean and Insulin-Sensitive State with Low Concentrations of Circulating Myostatin and Follistatin

Sebastiani Giorgia , Cruz Miriam Perez , Silva Marta Diaz , Roig Maria Dolores Gomez , Bermejo Abel Lopez , Toda Lourdes Ibanez , De Zegher Francis

Background: Muscle is key to glucose metabolism. Myogenesis is completed in early infancy, partly under the inhibitory control of myostatin, a myokine whose actions can be influenced by follistatin. Early lowering of myostatin actions is thus a potential strategy to reduce the risk for later diabetes.Objective and hypotheses: We performed a first screening of whether such lowering is among the natural mechanisms whereby some human infants augment their l...

hrp0082p2-d1-366 | Fat Metabolism & Obesity | ESPE2014

Uric Acid and Risk for Atherosclerotic Disease Early in Life

Bassols Judit , Martinez-Calcerrada Jose-Maria , Prats-Puig Anna , Carreras-Badosa Gemma , Diaz-Roldan Ferran , Osiniri Ines , Riera-Perez Elena , de Zegher Francis , Ibanez Lourdes , Lopez-Bermejo Abel

Background: Increased uric acid is an independent risk factor for cardiovascular disease in obese adults and adolescents. The relationship between uric acid and atherosclerotic risk early in life is unknown.Objective and hypotheses: We investigated whether uric acid relates to carotid intima–media thickness (cIMT), a marker of preclinical atherosclerosis, in a rather large sample of school-age children and investigated the interaction of obesity sta...

hrp0082p2-d2-378 | Fat Metabolism & Obesity (1) | ESPE2014

Circulating Concentrations of Fibroblast Growth Factor 21 are Undetectable in Human Infants at Term Birth and Surge within Hours After Birth

Sanchez-Infantes David , Gallego-Escudero Jose Miguel , Cereijo Ruben , Diaz Marta , Aragones Gemma , Lopez-Bermejo Abel , de Zegher Francis , Villarroya Francesc , Ibanez Lourdes

Background: In rodents, fibroblast growth factor 21 (FGF21), an endocrine member of the FGF family, is mainly produced in the liver and promotes glucose oxidation in several tissues; the circulating concentrations of FGF21 rise shortly after birth. In the human, the ontogeny of circulating FGF21 is essentially unknown.Objective and hypotheses: To assess whether there is also a neonatal surge of circulating FGF21 concen...

hrp0082p2-d3-408 | Fat Metabolism & Obesity (2) | ESPE2014

SHBG Integrates the Cardiovascular Risk and Metabolic Dysfunction of Gestational Obesity

Bassols Judit , Soriano-Rodriguez Pilar , Prats-Puig Anna , Carreras-Badosa Gemma , Miranda-Arce Miguel-Angel , Alvarez-Castano Elena , de Zegher Francis , Ibanez Lourdes , Lopez-Bermejo Abel

Background: Sex hormone-binding globulin (SHBG) is the major sex steroid carrier protein. Its production is negatively regulated by insulin and monosaccharides. The concentration of SHBG increases between 16 and 27 weeks gestation and is negatively associated with pre-gestational BMI and weight gain during pregnancy. The link of SHBG with cardiovascular risk is poorly understood.Objective and hypotheses: In obese pregnant women, we aimed to study the ass...

hrp0084fc8.1 | Obesity - Basic | ESPE2015

DLK1 Expression in Adipose Tissue Following Fetal Growth Restriction: Relation to Visceral Fat Expansion and Catch-Up Growth in Wistar Rats

Carreras-Badosa Gemma , Remesar Xavier , Prats-Puig Anna , Diaz-Roldan Ferran , Platero-Gutierrez Estibaliz , Martinez-Calcerrada Jose-Maria , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel

Background: DLK1 (PREF1) is a key inhibitor of adipogenesis and adipocyte differentiation. Adipose tissue expansion depends on adequate adipocyte differentiation. However, whether lower DLK1 expression facilitates adipose tissue expansion following fetal growth restriction is so far unknown.Objective and hypotheses: To study the expression of DLK1 in the adipose tissue of prenatally growth-restricted rats and its relat...

hrp0084p2-470 | Growth | ESPE2015

Hypomethylation within the Imprinted Dlk1 - Dio3 Domain: a Potential Regulatory Mechanism of Pre and Postnatal Growth

Prats-Puig Anna , Carreras-Badosa Gemma , Bassols Judit , Cavelier Patricia , Magret Agnes , Sabench Cristina , Zegher Francis de , Ibanez Lourdes , Feil Robert , Lopez-Bermejo Abel

Background: Genomic imprinting causes genes to be expressed or repressed depending on their parental origin. The 1-Mb DLK1-DIO3 imprinted domain is located on human chromosome 14. Gene expression along this cluster is regulated by an intergenic differentially methylated imprinting control region (‘IG-DMR’). In mice, altered gene dosage within this cluster is associated with alterations in embryonic and placental growth.Objective and hy...

hrp0084p2-483 | Growth | ESPE2015

Hypermethylation at the Imprinted C19mc Microrna Cluster: A New Link between Maternal Metabolism and Infant’s Growth

Prats-Puig Anna , Carreras-Badosa Gemma , Bassols Judit , Girardot Michael , Carrion Empar , Gehmis Radu , Zegher Francis de , Ibanez Lourdes , Feil Robert , Lopez-Bermejo Abel

Background: Maternal obesity can have long-term consequences for the offspring’s health, including increased risk of type-2 diabetes and cardiovascular disease. The C19MC imprinted locus on chromosome 19q13.4 comprises a cluster of 46 microRNAs, which are usually expressed only in the placenta and from the paternal allele exclusively. Besides its role favouring trophoblast migration, the C19MC locus is deregulated in several human cancers. It is unknown ...

hrp0094p2-181 | Fat, metabolism and obesity | ESPE2021

Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children

Carreras-Badosa Gemma , Gomez-Vilarrubla Ariadna , Mas-Pares Berta , Puerto-Carranza Elsa , Diaz-Roldan Ferran , Riera-Perez Elena , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel ,

Introduction: Both the innate and adaptive immune responses are deregulated in individuals with obesity and are a key driver of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully understood.Methods: We examined whether serum GDF-15 was related to serum levels of ...