hrp0094p2-378 | Pituitary, neuroendocrinology and puberty | ESPE2021

The effect of 3 years of Gonadotropin-Suppressive Therapy in Girls with Early Puberty: Height Z Score in Relation to Mid-Parental height Z score.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma , Alyafei Fawzia ,

Introduction: Early and fast puberty (EFP) in girls, defined as pubertal onset at age 8-9 yr., with an accelerated course, may cause compromised final adult height (FAHt). Treatment with a gonadotropin-suppressive agent is still controversial because the improvement in FAHt is equivocal and there may be a risk of overweight.Aim of the study: We analyzed the data of 24 girls with EFP treated with GnRH analog (GnRH) since Tanner stage 2-3,...

hrp0094p2-389 | Pituitary, neuroendocrinology and puberty | ESPE2021

Atypical Presentation of Pituitary Macroadenoma in an adolescent girl: Central Hypothyroidism and Attenuated Pubertal Growth Spurt.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma ,

Introduction: Hyperprolactinemia (HPrl) secondary to macroadenoma is a rare endocrinopathy in childhood but represents one of the most frequent forms of pituitary adenoma.Case report: A 12yr old girl was referred for assessment of progressive weight gain in the last 1.5 years. Despite trials of weight control by changing the dietary habit and daily exercise weight her BMI SDS increased from 1.2 to 2.2. This was associated with progressiv...

hrp0097p1-89 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Maternal, placental and fetal IGF-1/IGFBP in Diabetic pregnancies and their effect on fetal/infantile growth

Soliman Ashraf Alaaraj Nada , Ahmed Shayma , Alyafei Fawzia , Soliman Ashraf

Introduction: In diabetic pregnancies, data about the interaction between maternal, placental, and fetal IGF1/IGFBP in relation to newborn size is not clear,Aim: To review research papers published in Pubmed, Google scholar, Research gate, and Scopus in the past 20 years on the relation between placental IGF1/IGFBP-1 and fetal/infantile/childhood growth in pregnancies associated with maternal diabetes.<p class="abste...

hrp0097p1-107 | GH and IGFs | ESPE2023

The Growth Predictive Value of (IGF1/Growth Hormone Peak) Ratio in Children with Idiopathic Short Stature (ISS)

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Introduction: Stimulated GH peak values have been shown to correlate well with nocturnal GH peak values and with nocturnal mean GH values. In addition, the expression level of serum IGF-1 in ISS has been shown to be significantly lower than that in normal children despite their normal GH peak response to provocation. GH stimulates the production of IGF1; however, their metabolic effects are different. GH has lipolytic and anti-insulin actions while IGF1 has in...

hrp0097p1-125 | Growth and Syndromes | ESPE2023

Significant Linear Growth Impairment in a carrier of an interstitial deletion of *356-kb within cytogenetic band 22q11.21 with good response to growth hormone therapy.

Soliman Ashraf , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Ahmed Shayma

Introduction: The 22q11 deletion is one of the most commonly recognized deletion syndromes in humans (~ 1/4000 live births). Most of the reported defect generally involves a deletion at breakpoints LCR22A and LCR22D causing DiGeorge or velo-cardio-facial syndrome. In deletion syndromes, the phenotype ranges from unspecified dysmorphic features to severe cognitive/behavioral deficits, but normal features can occur depending on the size and amount of gene dosage...

hrp0097p1-129 | Growth and Syndromes | ESPE2023

Qatar population-specific centile charts of placental weight to birth weight (PW/BW) ratio in 80 722 newborns born between the 37 th and 42 nd Weeks of Gestation: Relation to Gestational Age, and Gender.

Alyafei Fawzia , Soliman Ashraf , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Background: Data about placental weight (PW) in relation to birth weight (BW) and gestational age (GA) are lacking in Arab countries.Objectives: To report the specific centile charts of PW/BW ratio in a large cohort of mother/baby pairs (n= 80277) born between 37th and 42nd weeks of gestation in relation to neonatal growth characteristics and gender.Methods: Retrospective ...

hrp0097p1-322 | Growth and Syndromes | ESPE2023

Postnatal Linear Growth Among Very Low Birthweight Infants (<1.5kg) in the first 2 years of life

Alyafei Fawzia , Soliman Ashraf , Ahmed Shyama , Hamed Noor , Alaaraj Nada

Background: Very Low birthweight (LBW) is defined as birthweight below 1.5 kg) and compared to AGA they are reported to be at a higher risk to develop slow postnatal growth outcomes.Objectives: To describe the postnatal growth of 120 VLBW newborns who had birth weight < 1.5 kg. linear growth trajectories of VLBW infants were compared with normal infants (WHO curves) during the first 24 months of life.<p class="abs...

hrp0097p2-68 | Fat, Metabolism and Obesity | ESPE2023

Gut Hormones in Malnourished infants and children: Important Role in Adaptation.

Soliman Ashraf , Alaaraj Nada , Alyafei Fawzia , Hamed Noor

The gastrointestinal (GI) tract is the body's largest endocrine organ producing hormones that have important sensing and signaling roles in the regulation of energy homeostasis and immune mechanisms.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim of providing an update on the changes occurring in gut hormones (Ghrelin, GLP-1 and PYY, insulin,...

hrp0097p2-82 | Growth and Syndromes | ESPE2023

Adipocyte Hormones (Leptin- Adiponectin) Changes and Their Possible Effects on Metabolism, and Immunity During Malnutrition; New Mechanisms of Action.

Soliman Ashraf , Alaaraj Nada , Rogol Alan , Alyafei Fawzia

Background: Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through secreting hormones that regulate multiple functions at both organ and systemic levelsObjectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on the link between adipocyte hormones and the immune system in in...

hrp0097p2-86 | Multisystem Endocrine Disorders | ESPE2023

Consequences of Hypogonadism and Potential Benefits of Sex Steroid therapy (HRT) in Children and Adolescents with Beta Thalassemia Major (BTM).

Soliman Ashraf , Yassin Mohamed , Alyafei Fawzia , Alaaraj Nada , Soliman Nada

Introduction: A recent review from 14 Mediterranean and Middle East countries (n=4477, mean age = 16.5 years) showed that the pooled prevalence of delayed puberty / hypogonadism in patients with BTM was 45.6%.Objectives: We reviewed the literature (Pubmed, Google scholar, Scopus, Research gate) (1995: 2022) on the consequences of hypogonadism and benefits of Sex Steroid therapy (HRT) in children and adolescents ...