hrp0098p2-178 | Growth and Syndromes | ESPE2024

Co-Occurrence of DNET and Lymphoma in a patient with Noonan syndrome and mutation in PTPN11 gene

Rosa Pellicciari Caroline , Aparecida Siviero Miachon Adriana , Maria Spinola e Castro Angela , Maria Cappellano Andrea , Saba da Silva Nasjla , Augusto Vercillo Luisi Flavio , A. L. Jorge Alexander , C. Malaquias Alexsandra

Background: Noonan Syndrome (NS; OMIM 163950) is a common autosomal dominant disorder distinguished by facial dysmorphism, short stature, heart defects, chest deformities, and learning disabilities or mental retardation. NS stems from heterozygous germline causative variants in genes regulating the RAS/MAPK signaling pathway, including PTPN11, SOS1, RAF1, RIT1, KRAS, NRAS, BRAF, LZTR1, and SOS2. The condition exhibits considerable clinical variability and shar...

hrp0082p2-d1-533 | Puberty and Neuroendocrinology | ESPE2014

Polycystic Ovarian Syndrome in Adolescents: Metabolic Profile at Diagnosis, During and After Treatment with Oral Contraceptive

Arcari Andrea , Gryngarten Mirta , Ballerini Maria Gabriela , Freire Analia , Rodriguez Maria Eugenia , Ropelato Maria Gabriela , Bergada Ignacio , Escobar Maria Eugenia

Background: Obesity and unfavorable metabolic profile (insulin resistance and/or dyslipidemia) are frequently observed in Polycystic Ovarian Syndrome in Adolescents (PCOS) girls regardless of weight.Objective and hypotheses: To evaluate clinical features and metabolic profile in PCOS adolescents, before, during and after Oral Contraceptive (OC) treatment.Method: We performed a retrospective study on 51 girls with PCOS diagnosed acc...

hrp0086p1-p468 | Fat Metabolism and Obesity P1 | ESPE2016

Association of Fasting Triglycerides to High-Density Lipoprotein Ratio with Risk for Metabolic Disorders in Children

Efthymia Katsa Maria , Ioannidis Anastasios , Zyga Sofia , Sachlas Athanasios , Tsironi Maria , Paola Rojas Gil Andrea

Background: Atherosclerosis begins in childhood and progresses silently. Triglycerides/HDL ratio(TG/HDL) is a risk factor for cardiovascular diseases.Objective and hypotheses: To investigate TG/HDL as possible predictive factor for metabolic disorders in children.Method: Descriptive correlation, with 110 children (6–12 years old) in Sparta, Greece. Anthropometric and biochemical analyzes were performed.R...

hrp0094p2-365 | Pituitary, neuroendocrinology and puberty | ESPE2021

Gonadotropin Flare with Different Depot GnRH Agonists: Comparative Analysis.

Freire Analia , Arcari Andrea , Gabriela Ballerini Maria , Ignacio Bergada , Gabriela Ropelato Maria , Gryngarten Mirta ,

Central precocious puberty (CPP) is effectively treated by inhibition of GnRH signaling through GnRH receptor desensitization with depot GnRH agonists (dGnRHa), but the first injection is associated with a surge in LH and FSH (flare) that proportionally increases estradiol levels. When estradiol levels drop, usually within a fortnight, vaginal bleeding may be seen in a small number of girls. Although dGnRHa that use higher, longer-acting doses are increasingly being used in gi...

hrp0094p1-108 | Adrenal B | ESPE2021

Circadian rhythm of cortisol in saliva in obese children with clinical signs of hypercortisolism

Gabriela Ballerini Maria , Arcari Andrea Josefina , Brenzoni Luciana , Veronica Freire Analia , Eugenia Rodriguez Maria , Amaro Andrea , Bravlavsky Debora , Maggioni Irina , Keselman Ana , Bergada Ignacio , Gabriela Ropelato Maria ,

Due to the increase in prevalence of childhood obesity, more obese children are referred to the endocrinologist for the hypothalamus-hypophysis-adrenal axis assessment. The circadian rhythm (CR) of cortisol in saliva (SAF) may constitute a non-invasive, first line test to exclude hypercortisolism on obese children.Aim: To evaluate possible disturbances of CR of SAF in obese children with clinical signs of hypercortisolism.<p class="a...

hrp0084fc13.4 | Thyroid | ESPE2015

Effects of Initial Levothyroxine Dose on Growth and Neurodevelopmental Outcomes During the First Year of Life in Children with Congenital Hypothyroidism

Esposito Andrea , D'Onofrio Gianluca , Cassio Alessandra , Corrias Andrea , Gastaldi Roberto , Vigone Maria Cristina , Wasniewska Malgorzata Gabriela , Weber Giovanna , Salerno Mariacarolina

Background: An important issue in the management of congenital hypothyroidism (CH) is the best initial dose of levothyroxine (L-T4) in order to achieve optimal neurocognitive outcomes. Both European and American guidelines suggest an initial dose of 10–15 μg/kg per die but trials on long-term effects of different doses within this range are lacking.Objective and hypotheses: This was a multicenter randomized trial to ev...

hrp0086p2-p774 | Pituitary and Neuroendocrinology P2 | ESPE2016

Insulin Sensitivity in Girls with Central Precocious Puberty at Diagnosis and at 6 Months of GnRH Analogue Treatment

Arcari Andrea , Freire Analia , Escobar Maria Eugenia , Ballerini Maria Gabriela , Ropelato Maria Gabriela , Bergada Ignacio , Gryngarten Mirta

Background: Puberty is associated with a physiological decline in insulin sensitivity. Overweight and obesity are common among girls with Central Precocious Puberty (CPP). CPP and early menarche have been considered as risk factors for obesity and cardiovascular diseases during adulthood. Besides, concern has been raised by the potential impact of GnRH analogues (GnRH-a) treatment on body weight and metabolic profile.Objective and hypotheses: To evaluate...

hrp0084p2-374 | Fat | ESPE2015

Lifestyle Habits and Arterial Hypertension in Children and Adolescents

Daratsianou Maria , Ioannidis Anastasios , Zyga Sofia , Koutsovitis Paraskevas , Sachlas Athanasios , Xrona Maria , Batsikoura Maria , Katsa Maria Efthymia , Magana Maria , Andronikakis Eleftherios , Gil Andrea Paola Rojas

Background: Elevated blood pressure (BP) may occur from childhood, increasing the risk for hypertension in adulthood.Aim: To investigate the effect of anthropometric characteristics and lifestyle habits in children’s and adolescents’ BP.Methods: 949 children (<12 years old) from Lakonia, 178 teenagers (12–18 years old) from Athens and 372 from Kalamata, Greece, had participated during 2011–2014. A specially ...

hrp0082p3-d1-763 | Fat Metabolism &amp; Obesity | ESPE2014

Association of Lifestyle with Metabolic Syndrome in Children

Katsa Maria Efthymia , Zyga Sofia , Tsironi Maria , Ioannidis Anastasios , Sachlas Athanasios , Kolobos Petros , Magana Maria , Pistikou Anna Maria , Dimoliani Dafni Eleni Kougioumtzi , GIl Andrea Paola Rojas

Background: Metabolic syndrome (MetSyn) is defined as a group of disorders including diabetes mellitus, central obesity, dyslipidaemia, and hypertension.Aim: To investigate the role of lifestyle habits in correlation with MetSyn in children.Methods: In our research, 480 students, 6–12 years old, were participated living in Sparta–Greece. During 2011–2012, a specially designed questionnaire was used and anthropometric...

hrp0084p3-847 | Fat | ESPE2015

Uric Acid and Triglycerides/HDL Ratio as a Predisposing Factor for Metabolic Syndrome in Children

Katsa Maria Efthymia , Ioannidis Anastasios , Zyga Sofia , Tsironi Maria , Koutsovitis Paraskevas , Sachlas Athanasios , Kolovos Petros , Magana Maria , Daratsianou Maria , Paola Andrea , Gil Rojas

Background: Uric acid and Triglycerides/HDL ratio are an important risk factor for cardiovascular diseases.Aim: To investigate how Triglycerides/HDL ratio and uric acid are correlated with children’s biochemical and anthropometric characteristics, depending on the predisposition for metabolic syndrome (MetSyn).Methods: 110 students, 6–12 years old, living in Sparta-Greece, participated in our research. Anthropometric and ...