ESPE Abstracts

Background: The cardinal feature of the resistance to thyroid hormone (RTH) is reduced responsiveness of target tissues to thyroid hormone action caused by thyroid hormone receptor β gene (THRB) mutations impairing hormone binding in the majority (90%) of cases. It results in elevated serum levels of free thyroxine (FT4) and triiodothyronine (FT3) associated with unsuppressed thyroid SH.Objective and hypotheses: The ai...

Background: Polycystic ovary morphology (PCOM) in USG should not be identified with polycystic ovary syndrome (PCOS) and it is not a criterion for diagnosis of this syndrome in adolescents.Objective and hypotheses: Assessment of the usability of 3D ultrasonography in diagnostics of androgen excess disorders.Method: 40 girls aged 14–18 with hyperandrogenism were subjected to endocrinological examinations and transrectal USG of ...

Introduction: Craniopharyngiomas are slow growing epithelial tumors located in the sellar or suprasellar region of the brain. Adamantinomatous subtype affects mainly children and accounts for 5–10% of all intracranial paediatric tumors. Diagnosed antenatal and neonatal craniopharyngiomas are very seldom, about 40 such cases have been detected to date. They are characterised by large size, progressive hydrocephalus and a poor prognosis.Aim: The aim o...

Background: The development of the Hashimoto’s thyroiditis is the result of the damage to thyrocytes, apoptosis, and autoimmune cytotoxic action of lymphocytes.Objective and Hypotheses: The aim of the study is to present ultrastructural changes in thyroid cells in the course of damage in Hashimoto’s thyroiditis.Method: The study involved 40 children: 20 children with Hashimoto’s thyroiditis and 20 children as a contr...

Background: Combined pituitary hormone deficiency (CPHD) may be congenital or acquired disorder, which affects more than one hormonal axis. Congenital hipopituitarism includes heterogenic group of disturbances. It may be result of mutations or deletions in genes for signaling and transcription factors responsible for pituitary development. The disorder might affect one or multiple family members. The age of appearance and intensity of the first hormone deficiency symptoms may ...

Background: Septo-optic dysplasia (SOD) is a rare, congenital condition that mostly occurs sporadically, but can also be caused by mutations in HESX1, OTX2, SOX2, SOX3 genes. Symptoms of SOD include: optic nerve hypoplasia, hypopituitarism and midline brain abnormalities such as absence of septum pellucidum and/or corpus callosum. Hypopituitarism in SOD usually manifests as growth hormone deficiency followed by central hypothyroidism as well as deficiency of gonadotropines. Pr...

Background: Craniopharyngioma is a benign, slow-growing epithelial tumor, in children it contributes to 5–10% of all brain tumors. Its incidence is 0.5-2 per 1,000,000 person-years. 30–50% of these tumors are recognized in childhood, most often in ages 5–14, no sex predilection is observed. It is located mainly in the sellar/parasellar region, in children adamantinomatous variant, with tendency to recur, is the most common type. Views on the usefulness of immuno...

Background: There is still small clinical data regarding the influence of IDDM on bone structure, density and biochemical markers of bone turnover.Objective and hypotheses: To evaluate the potential role of OPG/sRANKL system in adolescents with IDDM and the influence of age, sex, metabolic control, diabetes duration and age of onset.Method: Serum concentration of OPG and total sRANKL in 60 children (25 boys and 33 girls) with IDDM ...

Background: Craniopharyngiomas are rare embryogenic malformations of the sellar area with low-grade histological malignancy. Its incidence is 0.5–2.0 cases per million persons per year, 30–50% of all cases become apparent in children.Objective and hypotheses: The aim of the study was to analyse the clinical symptoms and treatment efficacy in children diagnosed with Craniopharyngioma.Method: A retrospective analysis includ...

Background: Craniopharyngioma is low – grade malignant tumour with high survival rate. Its incidence is 0.5–2.0 cases per million persons per year. 30–50% of all cases occur in the childhood. The tumour location leads to numerous complications like deficits of pituitary function, impairment of vision, neuropsychological deficits and obesity. Excess body fat is observed in 40–50% of craniopharyngioma patients.Case presentation: We pres...