hrp0086p1-p607 | Growth P1 | ESPE2016

Effects of the Addition of Metformin to Recombinant Human GH on Bone Maturation and Pubertal Progression in Short Children Born Small-for-Gestational-Age

Capistros Mireia Tirado , Sancho Paula Casano , Toda Lourdes Ibanez

Background: Small for gestational age (SGA) children who experience rapid and exaggerated postnatal catch-up are prone to develop insulin resistance and to progress faster into puberty, resulting in a shorter final height. Short, non-catch-up SGA children treated with recombinant human GH (rhGH) may present with the same sequence. In a previous controlled study from our group performed in short SGA children, metformin – added to rhGH therapy – improved endocrine-meta...

hrp0089p2-p080 | Diabetes & Insulin P2 | ESPE2018

Betatrophin as a New Biomarker of Type 1 Diabetes Mellitus in Paediatrics

Ara Laura Bosch i , Villalba Adria , Murillo Marta , Fonolleda Mireia , Vazquez Federico , Rodriguez-Fernandez Silvia , Vives-Pi Marta , Bel Joan

Introduction: Type 1 Diabetes Mellitus (DM1) is an autoimmune disease resulting from the destruction of pancreatic β cells. After the diagnosis, up to 80% of patients spontaneously experience partial remission (PR) for months. New biomarkers are being studied, such as the betatrophin protein (ANGPTL8) of unknown function, but which could be involved in the evolution of DM1, in this phase of RP and even used as a therapeutic target.Methods: Observati...

hrp0098p2-106 | Fat, Metabolism and Obesity | ESPE2024

Comparative Analysis of the Discriminative Ability of BMI, TMI, and BMI zscore in Establishing Metabolic Syndrome Risk

Domingo-Ajenjo Julia , Torres-Martos Álvaro , Bustos-Aibar Mireia , Arteaga Maria , Vázquez-Cobela Rocio , Nagore Carlos , De Miguel Pilar , Alcalá-Fdez Jesús , Anguita-Ruiz Augusto , Leis Rosaura , M. Aguilera Concepción , Bueno-Lozano Gloria

Pediatric obesity is intimately related to the development of Metabolic Syndrome (MetS), which is a cluster of metabolic alterations associated with an increased risk of premature death. Some indexes of obesity, such as the Triponderal Mass Index (TMI), Body Mass Index (BMI), and Body Mass Index z-score (BMI-zscore), are used to identify children at high risk. This study aims to compare the discriminative ability of BMI, BMI and BMI-zscore to determine the risk of developing M...

hrp0098p2-394 | Late Breaking | ESPE2024

Identification of GNAS somatic variants in whole blood dna from patients with ovarian-origin peripheral precocious puberty using droplet digital pcr

Guimaraes Faria Aline , R Montenegro Luciana , Augusto Lima Jorge Alexander , Matsunaga Martin Regina , Candida B. V. Fragoso Maria , R Tinano Flavia , E Seraphim Carlos , Pinheiro Machado Canton Ana , Garcia Gomes Larissa , A Martos-Moreno Gabriel , Tarjuelo García Irene , Carcavilla Atilano , Tirado-Capistros Mireia , Christina Souza-Pinto Nadja , Argente Jesús , Bilharinho Mendonca Berenice , Claudia Latronico Ana , Nahime Brito Vinicius

Background: GNAS activating mutations are the genetic basis of McCune-Albright syndrome (MAS). Peripheral precocious puberty (PPP) due to functional ovarian cysts, with or without MAS features, denotes a potential GNAS -related disorder.Aim: To explore GNAS somatic mutations (p.R201C/H) in peripheral leukocyte DNA using ddPCR in girls with ovarian-origin PPP with or without MAS.<p class="ab...

hrp0086fc15.5 | Late Breaking | ESPE2016

Effect of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity, Measured by Euglycemic-Hyperinsulinemic Clamp Technique, in Children with obesity: A Randomized, Double-Blinded, Placebo-Controlled Trial

Garibay Nayely , Alvarenga Juan Carlos Lopez , Alvarez Flor , Bustos Mayra , Villanueva Erendira , Leon Mireya , Serratos Fabiola , Laresgoiti Estibalitz , Macias Teresa , Ramirez Fernando , Queipo Gloria

Background: Insulin resistance precedes metabolic syndrome abnormalities, and may promote cardiovascular disease and type 2 diabetes in obese children. Lifestyle modification programs have been proposed as the gold standard of care in these individuals. However, results have been discouraging and the use of adjuvant strategies has been necessary. Metformin has beneficial effects on weight reduction, favoring a decrease in body mass index (BMI) and insulin resistance in obese n...

hrp0089p3-p273 | Multisystem Endocrine Disorders P3 | ESPE2018

Endocrine Complications in Beta-Thalassaemia Major Children

Iancu Mirela Elena , Albu Alice Ioana

Introduction: Beta-thalassaemia major is an inherited anemia which requires chronic transfusions and is frequently associated with endocrine dysfunctions secondary to iron overload. The aim of this study was to identify the prevalence of various endocrine complications in beta-thalassaemia major children over a period of 14 years and the factors associated with them.Materials and methods: 61 children with BTM (mean age 12.23 years) registered at the Endo...

hrp0089p3-p294 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Growth Hormone Deficit Associated to Complex Arteriovenous Malformation – Case Report

Mogoi Mirela , Velea Puiu Iulian , Paul Corina

Background: Arteriovenous malformations (AVMs) are rare in kids, estimated to represent 3% of all AVMs. They tend to rupture more frequently than in adults and, usually, are brought to attention after rupture, as the most common non-traumatic intracerebral hemorrhage. AVMs could also present with recurrent seizures or headaches. Their optimal management remains controversial.Case report: We present the case of a 4.5 y old boy, presented in our department...

hrp0086p2-p540 | Fat Metabolism and Obesity P2 | ESPE2016

Analysing Child Obesity Risk Factors: Adenotonsillectomy

Paul Corina , Velea Puiu Iulian , Mogoi Mirela

Background: Adenotonsillectomy is one of the most common surgical procedure performed in children in Romania. Child obesity also, seems to follow the same trend of increasing prevalence as worldwide.Objective and hypotheses: To determine if there is a relationship between adenotonsillectomy and postoperative weight gain in children.Method: The retrospective four year study included 235 children. After applying the exclusion criteri...

hrp0082p3-d2-783 | Fat Metabolism &amp; Obesity (1) | ESPE2014

The Association Hypothyroidism: Obesity in a Group of Children and Adolescents

Paul Corina , Mogoi Mirela , Velea Iulian

Background: Several studies suggested that hypothyroidism, especially subclinical hypothyroidism (SH), is rather a consequence than one of the causes of excessive weight.Objective and Hypotheses: We analyzed if there is a correlation between serum TSH, free thyroxine (FT4) and anthropometric measures in a group of overweight and obese children.Method: The study included 92 children (46 girls and 46 boys), mean age: 11.79...

hrp0084p3-891 | Fat | ESPE2015

Bone Age Assessment and Glucose Metabolism in Overweight and Obese Children

Paul Corina , Mogoi Mirela , Velea Iulian

Background: Bone age (BA) tends to exceed chronological age (CA) in obese children. There are studies showing that insulin may directly influence skeletal growth. Objective: To determine whether there is an association between BA and glucose metabolism in a group of overweight and obese children.Methods: The study included 55 obese or overweight children, mean age: 11.56±3.07 years old. Anthropometric indexes (weight, height, BMI, waist circumferenc...