hrp0098p3-23 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Case report for a 15-year-old black girl with genu valgus and abnormal gait.

Soliman Ashraf , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Alyafei Fawzia

Background: Vitamin D deficiency in adolescents can lead to rickets, osteomalacia, and skeletal deformities such as genu valgus. Chronic deficiency may also have implications for growth and endocrine function. This case report describes the clinical presentation, management, and outcome of severe Vitamin D deficiency in a 15-year-old black girl with genu valgus and abnormal gait.Case Presentation: The patient presented w...

hrp0098p3-126 | GH and IGFs | ESPE2024

Unusual presentation of Growth hormone presentation (GHD

Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Ashraf

Introduction: Growth Hormone Deficiency (GHD) can manifest at birth with hypoglycemia, prolonged conjugated hyperbilirubinemia, and midline defects. Despite typically normal length at birth, early post-natal growth failure can be significant.Case Report: A 4-month-old girl presented to the Failure to Thrive (FTT) clinic with poor weight gain. Born full-term with a birth weight of 3 kg and length of 48 cm, she was initial...

hrp0098p3-127 | GH and IGFs | ESPE2024

A challenging case of Growth hormone deficiency (GHD) during the neonatal period

Alyafei Fawzia , Hamed Noor , Alaaraj Nada , Ahmed Shayma , Soliman Ashraf

Introduction: Growth Hormone Deficiency (GHD) can manifest at birth with hypoglycemia, micropenis, or prolonged conjugated hyperbilirubinemia. While neonatal length is often normal, early post-natal growth failure can be significant.Case Report: A 2-week-old girl born to a Type 2 diabetic mother (HbA1c 7% at end of pregnancy) via elective LSCS presented with normal birth metrics but was admitted to NICU due to hypoglycem...

hrp0098p3-129 | GH and IGFs | ESPE2024

Exploring the Impact of Growth Hormone Therapy on Glucose and Insulin Metabolism in Children with GH Deficiency: A Review

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Introduction: Children with growth hormone (GHD) often exhibit unique patterns in glucose and insulin metabolism, which could potentially deteriorate upon receiving GH therapy. This therapeutic intervention, while crucial for promoting normal growth, may inadvertently influence the intricate balance of glucose homeostasis and insulin sensitivity,Methods: We reviewed and analyzed 12 studies based on their relevance, in ch...

hrp0098p3-251 | Thyroid | ESPE2024

Comprehensive Review on the Mechanisms of Thyroxine Action on Growth and Brain Development

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma , Alyafei Fawzia

Introduction and Methods: We systemically reviewed the literature and analyzed key research papers from 1954 to 2023 on thyroxine action on growth and brain development.Results: (Table) Author(s): Year: Key Finding:...

hrp0095p1-320 | Growth and Syndromes | ESPE2022

International vs Qatar national growth data for identifying small and large-for-gestational-age newborns: A population-based study in Qatar

Alyafei Fawzia , Soliman Ashraf , Alqubasi Mai , Ali Hamdy , Alturk Mohamed , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Background: To update the ongoing debate about the use of universal strict vs (local) national intrauterine growth charts, we compared the prevalence of small and large-for-gestational-age (SGA/LGA) infants according to international charts and national growth data.Methods: We classified singleton births from 33 to 42 weeks of gestation in 2016 and 2019 from Qatar (n = 92431), SGA (birthweight <10th percentil...

hrp0095p1-331 | Growth and Syndromes | ESPE2022

Prevalence of Obesity from birth to 3 years of age in infants born large for date (LGA): Infants with weight for age (WAZ) catch down vs those without catch down during the first year of life

Fawzia Alyafei , Ashraf Soliman , Saleha Abbsi , Fatima Alkhori , Nada Alaaraj , Shayma Ahmed , Noor Hamed , Hamdy Ali

Introduction: Infants whose weight is > the 90th percentile for gestational age are classified as large for gestational age (LGA). Catch-up and catch-down growth can be defined as an increase or decrease in WAZ by > 0.67 SD respectively during the infantile period. It was suggested that in LGA rapid catch-up and/or no catch-down during infancy may be associated with the development of overweight (OW) and obesity (OB) during childhood.<p class="abstex...

hrp0095p1-531 | Growth and Syndromes | ESPE2022

Two years of Postnatal linear and head growth of term Infants Born Large for Date (LGA): Those who had infantile Length Z score (LAZ) and/or head circumference Z score (HCZ) catch down vs those without catch down.

Alyafei Fawzia , Soliman Ashraf , Abbsi Saleha , Alkhori Fatima , Ali Hamdy , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Introduction: Large for date (LGA) infants may have a higher tendency to become obese and tall. Catch-up and/or catch-down in linear growth, defined as an increase or decrease in length for age Z score (LAZ) by > 0.67 SD during the infantile period, may affect this tendency. Additionally, head circumference is well correlated with brain growth.Aim: We evaluated the prevalence of tall stature (LAZ > 1 and> 2) and...

hrp0095p2-165 | Growth and Syndromes | ESPE2022

Postnatal growth in Preterm infants as a function of their weight for gestational age (GA) (WAZ) at birth: Comparison between those who were born underweight (WAZ <-2) compared to those with normal weight (WAZ > -2)

Alyafei Fawzia , Soliman Ashraf , Alkhori Fatima , Abbso Saleha , AlYousef Doaa , Shaat Mona , Itani Maya , Alaaraj Nada

Introduction: Small size at birth is only a proxy for the pathological process of intrauterine growth restriction.Aim: To study the effect of different birth weights on postnatal growth.Method: We studied the linear growth of 59 infants who were born preterm (GA = 33.5 +/- 2.2 weeks) with birth weight >1.5 < 2.5 kg) for two years. They were classified at birth into two groups...

hrp0095p2-166 | Growth and Syndromes | ESPE2022

Postnatal growth in Preterm infants as a function of their head size (head circumference Z score (HCZ) at birth: Comparison between those who were with a large head (HCZ <-2) to those with normal Head size for gestational age (HCZ > -2)

Alyafei Fawzia , Soliman Ashraf , AlYousef Doaa , Shaat Mona , Itani Maya , Hamed Noor , Ahmed Shayma , Ali Hamdy

Suboptimal head growth in utero and in early neonatal life may affect linear growth and weight gain during infancy. We studied linear growth and weight gain of 56 preterms (GA = 33.5 +/- 2.2 weeks) with birth weight >1.5 < 2.5 kg) for two years. They were classified at birth into two groups (group 1 with HCZ <-1) (relatively small head for GA) (35 +/- 2 weeks) and group 2 with HCZ > -1 (GA = 33 +/- 1.7 weeks)Results: Preterm ...