hrp0095p2-58 | Diabetes and Insulin | ESPE2022

Real-world use of continuous glucose monitoring and its effect on glycemic control among Korean children, adolescents, and young adults with type 1 diabetes

Lee Dahye , Choe Yunsoo , Jeong Lee Yun , Ho Shin Choong , Ah Lee Young

Background: The Korean National Health Insurance Service has started reimbursing the cost of continuous glucose monitoring (CGM) in type 1 diabetes (T1D) in 2019. We investigated the effect of CGM use on glycemic control among Korean children, adolescents, and young adults with T1D in a real-world setting.Method: We retrospectively reviewed the medical records of childhood-onset T1D patients aged < 30 years (n</em...

hrp0092rfc7.4 | Diabetes and Insulin Session 2 | ESPE2019

Handgrip Strength Correlates with Insulin Resistance and the Metabolic Syndrome in Children and Adolescents: Analysis of the Korean National Health and Nutrition Examination Survey 2014-2016

Woon Jung Hae , Ah Lee Young , Yong Lee Seong , Ho Shin Choong , Won Yang Sei , Hyun Kim Jae

Introduction: Reduced muscle strength is associated with increased cardiometabolic morbidity and mortality. Handgrip strength (HGS) is an indicator of muscle strength and has been correlated with total muscle strength in children and adolescents. We aimed to evaluate the association between HGS and parameters of the metabolic syndrome and insulin resistance in children and adolescents.Methods: A total of 2,242 children a...

hrp0089p1-p090 | Diabetes &amp; Insulin P1 | ESPE2018

Increasing Trend of Fasting Plasma Glucose Levels and Impaired Fasting Glucose in Non-Diabetic Korean Youth and Young Adults: A Nationally Representative Population-Based Study

Lee Jieun , Ah Lee Young , Hyun Kim Jae , Yong Lee Seong , Ho Shin Choong , Won Yang Sei

Objectives: Diabetes in children and young adults is increasing worldwide. However, the study of change in fasting glucose among general pediatric and young adult population was lacking. The aim of this study was to investigate the secular trend of fasting plasma glucose (FPG) levels in non-diabetic Korean youth and young adults and to evaluate the change in the proportion of impaired fasting glucose (IFG).Methods: Study subjects were Korean youth aged 1...

hrp0089p1-p123 | Fat, Metabolism and Obesity P1 | ESPE2018

Interleukin-6 Levels are Associated with High Blood Pressure and Low HDL Cholesterol in Healthy 4-year-old Children

Jung Haewoon , Ah Lee Young , Lee Hye Jin , Lim Youn-Hee , Hong Yun-Chul , Shin Choong Ho , Yang Sei Won

Background: Interleukin-6 (IL-6) is a proinflammatory cytokine associated with obesity, insulin resistance, hypertension, and atherosclerosis in adulthood. Few studies have been conducted in healthy young children. We aimed to investigate whether IL-6 levels are associated with cardiometabolic risk factors in healthy 4-year-old children.Methods: From a prospective cohort study named Environment and Development of Children (EDC) cohort, a total of 421 sin...

hrp0092fc5.3 | Thyroid | ESPE2019

Predominant DICER1 Mutations in Pediatric Follicular Thyroid Carcinomas

Ah Lee Young , Im Sun-Wha , Cheon Jung Kyeong , Jae Chung Eun , Ho Shin Choong , Kim Jong-II , Park Young Joo

Background: Pediatric thyroid cancer has characteristics that are distinct from adulthood thyroid cancer. Due to its very low prevalence, little is known about the genetic characteristics of pediatric follicular thyroid cancer (FTC).Methods: We investigated genetic alterations in tumor tissues from 15 patients aged < 20 years (median: 14.3 years; range: 2.4-19.0 years) using multifaceted approaches. Whole-exome seque...

hrp0092t10 | Top 20 Poster | ESPE2019

Changes in Adrenal Androgens and Steroidogenic Enzyme Activities in Children Aged 2, 4, and 6 Years: Steroid Hormone Profiling From the Prospective Cohort Study

Hyun Kim Jae , Ah Lee Young , Ho Shin Choong , Yang Sei Won , Song Junghan , Lim Youn-Hee , Kim Bung-Nyun , Inhyang Kim Johanna , Hong Yun-Chul

Introduction: Adrenarche refers to the increase in adrenal androgen synthesis. However, process of adrenal androgen production in early childhood remains to be elucidated. The aim of this study was to evaluate changes in adrenal androgen levels and steroidogenic enzyme activities associated with adrenarche using a prospective cohort.Methods: A total of 229 children (124 boys, 52.4%), who had participated in the Envir...

hrp0092p1-431 | Thyroid (2) | ESPE2019

The Relationship Between Perfluoroalkyl Compounds Concentrations at Ages 2, 4, and 6 Years and Thyroid Function in Early Childhood: A Prospective Cohort Study

Young Kim Hwa , Kim Kyoung-Nam , Ah Lee Young , Lim Youn-Hee , Inhyang Kim Johanna , Kim Bung-Nyun , Oh Se-Young , Hong Yun-Chul , Ho Shin Choong

Backgrounds: Perfluoroalkyl compounds (PFCs) have been suggested as potential thyroid disrupting chemicals. However, previous studies about the associations between PFCs and childhood thyroid function are scarce, and inconclusive. We evaluated the PFC exposure in Korean preschool children, and investigated the temporal relationship with thyroid hormone concentration.Methods: From a prospective the Environment and Develop...

hrp0092lb-21 | Late Breaking Posters | ESPE2019

How Can the Occurrence of Delayed Elevation of Thyroid Stimulating Hormone in Preterm Infants Born Between 35 and 36 Weeks Gestation be Predicted?

Jung Heo You , Ah Lee Young , Jeong Lee Yun , Hee Lim Youn , Rim Chung Hye , Han Shin Seung , Ho Shin Choong , Won Yang Sei

Objective: We evaluated frequency and risk factors of delayed TSH elevation (dTSH) and investigated follow-up outcomes in the dTSH group with venous TSH (v-TSH) levels of 6–20 mU/L according to whether late preterm infants born at gestational age (GA) 35–36 weeks had risk factors.Methods: The medical records of 810 neonates (414 boys) born at Seoul National University Hospital who had a normal neonatal screenin...

hrp0092lb-23 | Late Breaking Posters | ESPE2019

Long-Term Safety and Effectiveness of Recombinant Human Growth Hormone in Korean Pediatric Patients with Growth Disorders: 7-year Interim Analysis from LG Growth Study

Ah Lee Young , Chung Sochung , Rhie Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Yoo Jae-ho , Ho Choi Jin , Tae Hwang Il

Objectives: This study aimed to evaluate the long-term safety and effectiveness of recombinant human growth hormone (rhGH) (Eutropin® Inj.., Eutropin®Pen Inj., Eutropin®AQ Inj., and Eutropin®Plus Inj., LG Chem, Ltd.) based on the interim analysis of a 7-year accumulated data of the LG Growth Study (LGS) in Korean pediatric patients with growth disorders including growth hormone deficiency (GHD), T...

hrp0095p1-499 | GH and IGFs | ESPE2022

Long-term safety and effectiveness of recombinant human growth Hormone inKorean pediatric patients with growth disorders: 9-year interim analysis fromLG Growth Study

Kim Yoo-Mi , Chung Sochung , Rhie Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Ho Choi Jin , Ah Lee Young , Sang Lee Hae , Tae Hwang Il

This study aimed to evaluate the long-term safety and effectiveness of recombinant human growth hormone (rhGH; Eutropin®, Eutropin®Pen, Eutropin®AQ, and Eutropin®Plus, LG Chem, Ltd.) treatment in Korean pediatric patients. This observational study has been conducted since 2011, and the data were collected up to August 2021 for interim analysis. The incidence rates of all adverse events (AEs) were assessed for safety a...