hrp0089p2-p082 | Diabetes & Insulin P2 | ESPE2018

IGF-1 Relationship with Growth Velocity in Precocious Puberty with GnRHa Treatment

Sahin Nursel Muratoglu , Cetinkaya Semra , Erdeve Senay Savas , Aycan Zehra

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

hrp0086p2-p682 | Growth P2 | ESPE2016

Calcaneal Apophysitis (Sever’s Disease) Development in a Case Using Growth Hormone

Kurnaz Erdal , Erdeve Senay Savas , Aycan Zehra , Cetinkaya Semra

Background: Orthopedic complications related to the GH are rare and there is no clear pathological association between the use of GH and these complications. Calcaneal apophysitis is an inflammation of the apophysis and is caused by the constant pull of the Achilles tendon. A literature search did not reveal a similar case of calcaneal apophysitis during GH use.Case presentation: A 13-year-old male receiving GH treatment for isolated GH deficiency presen...

hrp0092fc10.6 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Evaluation of Basal and GNRH-stimulated AMH Levels in Central Precocious Puberty, Peripheral Precocious Puberty and Premature Thelarche

Sahin Nursel Muratoglu , Yilmaz Aslihan Arasli , Erdeve Senay Savas , Cetinkaya Semra , Aycan Zehra

Objective: AMH decreases by 30% in the first two years following puberty. Although it is known that AMH is associated with FSH and LH, the AMH response to rapid changes in GnRH is not known clearly in puberty. It has been shown that AMH levels in central precocious puberty (CPP) are lower than in premature thelarche (PT), but the levels of AMH in peripheral precocious puberty (PPP) have not been evaluated. The aim of this study was to evaluate the basal an...

hrp0092p1-284 | Thyroid (1) | ESPE2019

Different Endocrine Affects in DICER-1 Syndrome

Yilmaz Aslihan Arasli , Aycan Zehra , Erdeve Senay Savas , Çetinkaya Semra

Introduction: DICER1 syndrome is a pleotropic, autosomal dominant familial genetic tumor predisposition syndrome. DICER1 somatic + germ-line mutations (double hit hypothesis); cystic nephroma; pleuropulmonerblastoma, ovarian sex cord-stromal tumors, multinodular goitre (MNG) are associated with many conditions such as differentiated thyroid cancer, pituitary blastoma. We presented three cases, two of whom were siblings, who had been consulted because of no...

hrp0092p1-330 | Diabetes and Insulin (2) | ESPE2019

Evaluation of Clinical, Laboratory and Therapeutic Features and Long Term Follow-up Results in 44 Cases with Genetic Diagnosis of MODY; Single Center Experience

Ozalkak Servan , Keskin Meliksah , Çetinkaya Semra , Erdeve Senay Savas , Bayramoglu Elvan , Aycan Zehra

Introduction-Aim: MODY;It is an autosomal dominant, rare type of diabetes that occurs in young people as a result of mutations of beta cell function and genes involved in insulin secretion. The cases may be misdiagnosed as Type1 and Type2 diabetes. Considering that MODY is clinically and genetically heterogeneous, the findings should be evaluated correctly. It is important to define the clinical-laboratory characteristics of diagnosis and follow-up of patients...

hrp0082p2-d1-532 | Puberty and Neuroendocrinology | ESPE2014

Evaluation of the Free Androgen Index in Adolesent Females Diagnosed with Obesity, Hirsutism, and PCOS

Sagsak Elif , Aycan Zehra , Keskin Meliksah , Erdeve Senay Savas , Cenesiz Funda , Ocal Fatma Doga , Cetinkaya Semra

Background: It is difficult to define the laboratory finding of hyperandrogenism and associate it with clinical findings in children and adolescents. Androgen levels can be high in obesity, hirsutism, and PCOS. The free androgen index (FAI) is a simple ratio used to evaluate the biologically active testosteroneObjective and hypotheses: Our aim was to determine the FAI in adolescent females and to evaluated how this index is influenced in adolescents diag...

hrp0082p2-d2-607 | Thyroid (1) | ESPE2014

Premature Menarche Associated with Hashimoto Thyroiditis at 2 Years 9 Months: Case Report

Keskin Meliksah , Cetinkaya Semra , Sagsak Elif , Aycan Zehra , Erdeve Senay Savas

Background: Primary hypothyroidism is frequently associated with delayed puberty. However, precocious puberty is known to occur in some rare cases of hypothyroidism untreated for a long time. Differently from the cases suffering from precocious puberty due to other causes, linear growth and bone age are retarded in children developing precocious puberty associated with hypothyroidism. There are no definite data about the incidence of precocious puberty associated with hypothyr...

hrp0082p3-d2-677 | Bone (1) | ESPE2014

Risk Factors Affecting the Development of Nephrocalcinosis, the Most Common Complication of Hypophosphatemic Rickets

Keskin Meliksah , Erdeve Senay SavaS , Sagsak Elif , Aycan Zehra , Cetinkaya Semra

Background: Hypophosphatemic rickets is a clinical picture with inadequate bone mineralization that develops following renal phosphate loss. One of the most common complications in this group of patients is nephrocalcinosis. However, the mechanisms causing nephrocalcinosis are not clear.Objective and hypotheses: The aim of our study was to define the risk factors affecting the development of nephrocalcinosis, which is reported to be seen at a rate of 50%...

hrp0082p3-d1-958 | Sex Development | ESPE2014

17βHSD-3 Enzyme Deficiency in Newborn Due to a Novel Mutation in HSD17B3 Gene

Sagsak Elif , Aycan Zehra , Erdeve Senay Savas , Keskin Meliksah , Cetinkaya Semra , Karaer Kadri

Background: 17β-Hydroxysteroid dehyrogenase type 3 (17βHSD-3) deficiency is an autosomal recessive form of 46,XY disorder of sex development (DSD). 17βHSD-3 is present almost exclusively in the testes and converts androstenedione to testosterone. The diagnosis can be easily missed in early childhood as the clinical presentation may be subtle. The most frequent presentation of 17βHSD-3 deficiency is a 46,XY individual with female external genitalia, labial f...

hrp0084p3-999 | Gonads | ESPE2015

Sertoli Cell Tumour in a Case of Androgen Insensitivity Syndrome

Erdeve Senay Savas , Aycan Zehra , Keskin Meliksah , Cetinkaya Semra , Karaman Ayse , Apaydin Sema , Cakmakci Emin

Introduction: Complete androgen insensitivity syndrome (CAIS) is a sexual development disorder due to mutations that cause function loss in androgen receptors in 46, XY individuals. The risk of malignancy development until the age of 25 years in CAIS is 5–10%. We present a CAIS case where a Sertoli cell tumour was found, together with the USG and MR findings.Case: A 17-year-old female presented to our department complaining of amenorrhoea. She had a...