ESPE Abstracts

Introduction: Pituitary stalk interruption syndrome is a rare congenital abnormality of the pituitary that is responsible for anterior pituitary deficiency. It is characterized by a classic triad of interrupted pituitary stalk, absent or ectopic posterior pituitary, and anterior pituitary hypoplasia or aplasia. Clinical presentation varies according to age. Early diagnosis and treatment of this rare disease can prevent permanent short statue of the patient. We...

Background: Hearing problems and ear malfunctions are frequent in Turner syndrome (TS) and correlate with the karyotype. As a result of the frequent otitis media, conductive hearing loss is common in girls with TS. Sensorineural hearing loss is also common and may occur as early as 6 years of age.Objective and hypotheses: This study reviewed a cohort of children to clarify the incidence and pattern of conductive and sensorineural hearing loss in girls wi...

Introduction: Changes in thyroid function and thyroid function tests occur in patients with β-thalassemia major (TM). The frequency of hypothyroidism in TM patients ranges from 4% to 29 % in different reports. Bone marrow transplantation (BMT) is based on destruction of the patient’s bone marrow with rescue of haematopoietic stem cells from a donor. Chronic graft-vs-host disease (GVH) is the major complication post-BMT and mimics some autoimmune diseases, such as ...

WHO defines children born with intrauterine growth restriction (IUGR) as those with a birth weight below the 10th percentile of recommended birth weight by sex for gestational age. When gestational age is not available, a birth weight < 2500 g should be considered. The adult height in IUGR children treated with GH depends mainly on the duration of treatment and the age of initiation. Early diagnosis and early management before puberty are therefore imperative.<p class="...

Introduction: Radiation induced growth hormone deficiency (GHD) is one of several important factors in the aetiology of short stature complicating the treatment of brain tumours in childhood. If such a child is clinically well,shows a poor growth rate and biochemical evidence of GH deficiency,then a 1 year trial of GH is justified.The aim of this study is to evaluate growth and assessed Pituitary function (GH deficiency) in children who ...

Abstract: The risk of developing coeliac disease (CD) is higher in Turner syndrome (TS) than the general population, and screening has been recommended in asymptomatic individuals known to have an increased risk of developing the disease. In light of this recommendation, the aim of the study was to assess prevalence of celiac disease in Turner syndrome.Patients and methods: Serological screening of coeliac disease were performed in 85 children and adoles...

Background: Central diabetes insipidus (DIC) is usually the final result of lesions affecting the hypothalamic–neurohypophyseal system, for the children, germinoma is the main reason. The MRI aspect is often limited to thickness pituitary stalk with loss of hyperintensity of the neurohypophysis.Objective and hypotheses: Thickening of pituitary stalk is suggestive of germinoma, the clinical picture is dominated by a DIC (90%), associated to hypopitui...

Background: Magnetic resonance imaging (MRI) is advisable in all patients with GH deficiency (GHD). MRI pituitary morphology has important clinical implications, both in terms of diagnostic accuracy and long-term prognosis; indeed, when MRI findings are appropriately interpreted, they clearly represent a gold standard to investigate the etiology of GHD.Objective and hypotheses: To evaluate frequency and type of MRI anomalies in children with GHD, after d...

Introduction: Lesional hypothalamic obesity is most frequently attributable to craniopharyngiomas. The aim of our work is to describe the modalities of occurrence of this complication in a series of 27 children with craniopharyngioma followed in our center. We carried out a descriptive retrospective study of 27 cases of craniopharyngioma in children followed in the endocrinology department of the CPMC over a period of 16 years.Re...

Background: Low bone mineral density (BMD) in patients with Turner syndrome (TS) has been reported in a considerable number of previous studies. Cortical and trabecular bone have been involved. Osteoporosis can be over diagnosed in TS patients with a short stature unless BMD measurements are adjusted for body size. Optimization of bone health in girls with TS requires a healthy active lifestyle, including adequate calcium, vitamin D, and hormonal replacement therapy, according...