ESPE Abstracts

Purpose: In the diagnosis of central precocious puberty (CPP), the gonadotropin-releasing hormone (GnRH) stimulation test using intravenously injected gonadorelin is the gold standard. However, gonadorelin is not always readily available. In this study, the diagnostic accuracy of a test based on the GnRH agonist triptorelin acetate (triptorelin) was compared to that of the classical gonadorelin-based test in the diagnosis of CPP in girls.<p class="abstext"...

Abstract: Background: Makorin ring finger protein 3 (MKRN3) is most common genetic cause of central precocious puberty (CPP) and associated with the initiation of puberty. Although its actual function is veiled. Recent study reported MKRN3 interacted with and suppressed neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in mice.Objective: The aim of this study was t...

Neonatal thyrotoxicosis is rare and most of the cases are secondary to maternal Graves’ disease. It is usually transient, but can be associated with significant morbidity and mortality if not recognized promptly and treated adequately. We report a case of a 20-day-old female infant who developed thyrotoxicosis with irritability, tachycardia, and relatively poor weight gain. She was born to a mother who took levothyroxine during pregnancy after undergoing a thyroidectomy ...

Introduction: Skeletal muscle plays a crucial role in glucose disposal, and studies have shown a positive relationship between muscle mass and insulin sensitivity. However, an elevated lean mass has also been associated with metabolically adverse outcomes. This study aimed to evaluate the association between the risk of metabolic syndrome (MetS) and lean mass using dual-energy X-ray absorptiometry (DXA) in a nationally representative sample from the Korea Nati...

Background: Central precocious puberty (CPP) manifests through the activation of the hypothalamic-pituitary-gonadal axis before the age of 8 in girls and is increasing worldwide, but its causes and prevention methods remain mostly unclear. Premature thelarche (PT) is a benign condition but needs to be differentiated from CPP.Objective: To investigate the microRNA (miRNA) expression profiles in CPP and distinguish it from...

Purpose: We investigated uric acid reference values and their association with cardiometabolic risk among children and adolescents using the Korea National Health and Nutrition Examination Survey (KNHANES).Methods: A total of 2,462 participants, aged 10-18 years, from the KNHANES 2016-2018 were included.Results: Serum uric acid (SUA) levels varied with sex and age. In male subjects...

Background: Leptin, ghrelin, and nesfatin-1 are peptide hormones which regulates food intake, energy homeostasis and growth hormone synthesis.Objectives: To evaluate the relationship between leptin, ghrelin and nesfatin-1 with catch-up growth (CUG) in children born small for gestational age (SGA).Methods: A total of 67 children were included; 34 children born SGA without CUG, 17 ch...

Background: Small for gestational age (SGA) children are defined by birth weight and/or length at least 2 standard deviations (S.D) below the population mean for gestational age. Up to 90% of these infants experience catch-up growth within the first two years of life; however, 10-15% fail to do so, remaining short at age 2 (SGA-SS). The etiology of failure to achieve catch-up growth remains largely unknown.Methods: This ...