hrp0089p2-p082 | Diabetes & Insulin P2 | ESPE2018

IGF-1 Relationship with Growth Velocity in Precocious Puberty with GnRHa Treatment

Sahin Nursel Muratoglu , Cetinkaya Semra , Erdeve Senay Savas , Aycan Zehra

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

hrp0092fc10.6 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Evaluation of Basal and GNRH-stimulated AMH Levels in Central Precocious Puberty, Peripheral Precocious Puberty and Premature Thelarche

Sahin Nursel Muratoglu , Yilmaz Aslihan Arasli , Erdeve Senay Savas , Cetinkaya Semra , Aycan Zehra

Objective: AMH decreases by 30% in the first two years following puberty. Although it is known that AMH is associated with FSH and LH, the AMH response to rapid changes in GnRH is not known clearly in puberty. It has been shown that AMH levels in central precocious puberty (CPP) are lower than in premature thelarche (PT), but the levels of AMH in peripheral precocious puberty (PPP) have not been evaluated. The aim of this study was to evaluate the basal an...

hrp0092p1-342 | Fat, Metabolism and Obesity (2) | ESPE2019

Can Increased First Hour Glucose Concentration in OGTT Be a New Indicator in Projecting Metabolic Profile?

Sahin Nursel Muratoglu , Yilmaz Aslihan Arasli , Özalkak Servan , Aycan Zehra

Aim: Recent studies have shown that the first hour glucose concentration of ≥155 mg / dL in the oral glucose tolerance test (OGTT) in adults with normal glucose tolerance (NGT) may be a strong marker for the development of diabetes, and also an increase in subclinical inflammation, insulin resistance, dyslipidemia and serum transaminases. These results indicate that adults with NGT have increased risk of developing cardiovascular disease and non-alcoholi...

hrp0089fc12.4 | Diabetes and Insulin 2 | ESPE2018

How Does Thiol/Disulphide Homeostasis Change in Children with Type 1 Diabetes Mellitus?

Durmus Sevgi Yasar , Sahin Nursel Muratoglu , Erel Ozcan , Neselioglu Salim , Aycan Zehra

Introduction: Increased cytokine release, impaired antioxidation and reactive oxygen species (ROS) have been shown in β-cells in pathogenesis of T1DM. Increased ROS leads to formation of covalent bonds between the sulfur atoms, leading to disulphide conversion. Displacement to disulphide form of this thiol/disulphide balance starts the oxidative damage. This study evaluates the thiol/disulphide balance in children with T1DM.Material...

hrp0094p2-355 | Pituitary, neuroendocrinology and puberty | ESPE2021

Did Central Precocious Puberty Increase in COVID 19 Pandemic?

Orman Burce , Esen Senem , Keskin Meliksah , Sahin Nursel Muratoglu , Savas Erdeve Senay , Cetinkaya Semra ,

Background: The timing of puberty in children is occurring at an increasingly early age. During the COVID19 pandemic period, children experienced changes such as epidemic stress, sedentary life, and weight gain.Aim: To make a retrospective evaluation of the incidence of newly diagnosed central precocious puberty (CPP) during the first months of COVID-19. And to compare these corresponding data with the previousy ear....

hrp0092p1-348 | Fat, Metabolism and Obesity (2) | ESPE2019

Evaluation of the Relationship Between Serum Uric Acid Level and Cardiometabolic Risk in Obese Children and Adolescents

Yilmaz Aslihan Arasli , Sahin Nursel Muratoglu , Bayramoglu Elvan , Özalkak Servan , Erdeve Senay Savas , Çetinkaya Semra , Aycan Zehra

Background: In adult studies, serum uric acid level (SUA) has been shown to be associated with cardiometabolic anomalies of metabolic syndrome such as insulin resistance, hypertension, increased carotid intima thickness, and hyperuricemia is considered as an independent risk factor for atherosclerosis and cardiovascular disease. Early cardiovascular changes in obese children and studies on the relationship between metabolic syndrome and hyperuricemia are quite...

hrp0089p1-p242 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

AMH Level of Infants with Premature Thelarche and Possible Relationship between AMH and Mini-puberty

Sahin Nursel Muratoglu , Bayramoglu Elvan , Ozcan Hatice Nursun , Kurnaz Erdal , Keskin Meliksah , Erdeve Senay Savas , Cetinkaya Semra , Aycan Zehra

Background/aims: AMH levels of mini puberty are higher than prepubertal period. In this study we investigated AMH levels in infants with premature thelarche who are presumed to have exaggerated mini puberty due to inadequate/late suppression of pubertal activation.Methods: Fifty five female infants between 3 months and 3 years of age with premature thelarche were enrolled in the study and 49 healthy girls in the same age group were included in the study....

hrp0086p2-p856 | Syndromes: Mechanisms and Management P2 | ESPE2016

A Rare Cause of Short Stature: Patient with 3M Syndrome Revealed a New Mutation in Osbl1 Gene

Keskin Melikşah , Sahin Nursel Muratoglu , Kurnaz Erdal , Bayramoglu Elvan , Erdeve Senay Savas , Aycan Zehra , Cetinkaya Semra

The 3M syndrome is a rare autosomal disorder that can lead to short stature, dysmorphic features and skeletal abnormalities with normal intelligence. A-one year and four month-female patient had been reffered to our clinic for growth and developmental delay. Case history revealed a birth weight of 1740 grams on 39th week of gestation, with 42 cm body height and no prior hereditary conditions of clinical significance in her family. On physical examination, her height was 67 cm ...