ESPE Abstracts

Background: Obesity has a permanent effect on children’s health and acts as a major risk factor for chronic diseases. Therefore considering the children’s BMI is a vital parameter at each visit. This study was performed to measure prevalence of obesity and its determinants in school children of Zahedan in Iran; Zahedan is the capital of Sistan-and-Balouchestan province which is known to have the highest prevalence of underweight in Iranian children.<p class="abst...

Congenital hypothyroidism (CH) occurs in approximately 1:2,000 to 1:4,000 newborns, in Algeria newborn screening programs do not exist, untreated CH remains a significant health and societal challenge. We report the case of a girl of 12 years old reffered for a failure to thrive, speech deficit and persistant vomiting, On clinical examination her height was –3 SDs with a very delayed bone age and a BMI of 35kg/m2 associated with severe musculoskeletal deformities and cog...

Background: Diabetic ketoacidosis is a common complication of Type 1 diabetes Mellitus (T1DM). Unfortunately, medical errors are not uncommon during management of DKA leading to significant morbidity and mortality. Junior doctors/residents are usually the clinicians who initiate the management of DKA. There are many studies conducted to assess the knowledge of junior doctors, residents, and medical students in management of DKA in many countries including Bahr...

Background: Growth hormone deficiency (GHD) is one of the main endocrine disorders causing short stature. It may be due to isolated growth hormone deficiency (IGHD) or associated with multiple pituitary hormone deficiency (MPHD). The aim of this study was evaluation of anthropometric factors before and after growth hormone (GH) therapy.Patients and method: This is a historical cohort study. The diagnosis of GHD in childr...

Introduction: obesity is a major health problem worldwide and its incidence is increasing annually. Adipose tissue produces and regulates many hormones and cytokines which have relationship with obesity comorbidity. Serum level of vitamin D has been previously reported to have a negative relationship with obesity.Objective: To evaluate the relationship between vitamin D status and leptin, adiponectin, lipid profile and I...

Background: Congenital adrenal hyperplasia (CAH) is caused by different enzyme deficiency in the pathway of corticosteroid synthesis resulted in disorder of sex development (DSD) and may affect sexual identity in patients.Objective and hypotheses: To assess gender identity in patients with CAH.Method: In this study, 51 patients with CAH [21 children (5–14 years) and 30 adolescents and adults (15–37 years) were assessed us...

Introduction: Obesity is a rapidly growing health problem, with increasing worldwide prevalence. Obesity is accompanied by numerous metabolic and endocrine dysregulation. Thyroid dysfunction is one of the many metabolic aberrations that are associated with obesity. Thyroid dysfunction can be related to obesity, insulin resistance, and dyslipidemia. We aimed to study the thyroid function in children and adolescents with obesity and the metabolic parameters....

Introduction: Angiopoietin-like proteins (ANGPTLs) play critical roles in metabolism and are implicated in metabolic consequences of obesity. ANGPTL2 is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance. ANGPTL3 directly regulate lipid, glucose and energy metabolism independent of angiogenic effects. In this study, we aimed to investigate the levels of ANGPTL2 and 3 in obese children and adolescents and their assoc...

Background: CinnaTropin® (CinnaGen, Iran) is a recombinant human GH manufactured in Iran. Herein, we compared the efficacy and safety of the CinnaTropin® with the corresponding reference (Nordilet® Norditropin, Novo Nordisk, Denmark) in children with idiopathic GH deficiency (IGHD) and multiple pituitary hormone deficiency (MPHD).Methods: This was a randomized, open-label and cross-over study. Eligible pati...

Background: Optic nerve hypoplasia (ONH) is a congenital condition with high morbidity. Many children with ONH will develop pituitary hormone dysfunction (PHD), but it is unknown if, or when, this will occur.Objective and hypotheses: Our primary objective was to identify the type, timing and predictors of PHD in children with ONH to help guide the necessity and frequency for pituitary hormone testing.Method: A retrospective chart r...