hrp0089p3-p123 | Diabetes & Insulin P3 | ESPE2018

AID-GM System (Advanced Intelligent Distant – Glucose Monitoring) to Monitor Health Status and Metabolic Control of Young People with Type 1 Diabetes

Calcaterra Valeria , Sacchi Lucia , Salvi Elisa , Larizza Daniela , Made Alexandra , Schiano Luca Maria , Montalbano Chiara , Regalbuto Corrado , Bellazzi Riccardo , Larizza Cristiana

Aim of the study: In type 1 diabetes, it is well recognized that collecting additional information about diet, physical activity, health status, stress and any patients’ everyday behavior, is crucial to evaluate accurately metabolic control and therapeutic prescription adherence. The aim of this study is to test AID-GM (Advanced Intelligent Distant – Glucose Monitoring) a web-based platform, able of collecting automatically patient generated health data (PHGD) coming...

hrp0089p2-p126 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum Calprotectin Level in Children: Marker of Obesity and Its Metabolic Complications

Calcaterra Valeria , Amici Mara De , Silvestri Annalisa De , Michev Alexandre , Montalbano Chiara , Regalbuto Corrado , Schiano Luca Maria , Cena Hellas , Larizza Daniela

Aim: Circulating levels of calprotectin have been reported in obesity-related chronic low-grade inflammation in adults, but has not been evaluated in pediatric population. We investigated serum calprotectin in overweight and obese children and its association with metabolic comorbidities.Methods: We enrolled 131 children (11.7±4.1 years). According to BMI, the subjects were divided into three groups: obese >95th percentile; overweight BMI 75th&#...

hrp0089p2-p228 | GH & IGFs P2 | ESPE2018

Reliability of Clonidine Testing for the Diagnosis of Growth Hormone Deficiency in Children and Adolescents

Ibba Anastasia , Guzzetti Chiara , Casula Letizia , Salerno Mariacarolina , Di Iorgi Natascia , Maria Elsa Allegri Anna , Cappa Marco , Maghnie Mohamad , Loche Sandro

Introduction: The diagnosis of growth hormone deficiency (GHD) is currently based on clinical, auxological, biochemical, and neuro-radiological investigation. Provocative tests of GH secretion using physiological/pharmacological stimuli are required to confirm GHD. The clonidine test (CT) is widely used to assess GH secretory status. In this retrospective study we analyzed the reliability of CT and the effect of puberty in a large number of children with short stature who had ...

hrp0089p1-p221 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

High Mobility Group Box 1 (HMGB1) and Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2) are Increased, Insulin Decreased and IL-6 Unchanged in Follicular Fluid (FF) from Polycystic Ovarian Syndrome (PCOS)

Cirillo Francesca , Catellani Cecilia , Lazzeroni Pietro , Sartori Chiara , Morini Daria , Nicoli Alessia , Amarri Sergio , La Sala Giovanni Battista , Street Maria Elisabeth

HMGB1 is a small-protein which reflects both inflammation and insulin-sensitivity. Inflammation and insulin-resistance are features of PCOS. IL-6 is important for ovarian function and can contribute to insulin-resistance. IGFBP-2 behaves like an acute-phase protein and is increased in chronic inflammation. It is also involved in the glucose-metabolism regulation and IGFBP-2 overexpression plays a protective role against insulin-resistance. Insulin functions as a co-gonadotropi...

hrp0086rfc3.5 | Pituitary | ESPE2016

Prospective Dynamic Evaluation of Hypothalamo-Pituitary Function in 30 Cases of Paediatric Craniopharyngioma, by Hypothalamic Injury and Treatment; A Single Centre Series

Guzzetti Chiara , Losa Laura , Improda Nicola , Pang Gloria , Phatarakijnirund Voraluck , Gan Hoong-Wei , Hayward Richard , Aquilina Kristian , Ederies Ash , Spoudeas Helen A.

Background: Craniopharyngiomas are the commonest pituitary tumours of childhood. Though benign histologically, their localisation and invasive tendency can cause significant neuroendocrine morbidity and late mortality.Objective and hypotheses: To prospectively determine risk factors for neuroendocrine morbidity by longitudinal survival analysis.Method: All children with craniopharyngioma newly presenting to our quaternary centre be...

hrp0086p2-p504 | Fat Metabolism and Obesity P2 | ESPE2016

Analysis of Circulating miRNAs in Obese Children Born Small for Gestational Age

Faienza Maria Felicia , Marzano Flaviana , Inzaghi Elena , Annese Anita , Caratozzolo Mariano Francesco , D'Erchia Annamaria , Chiara Matteo , Horner David , Sbisa Elisabetta , Cavallo Luciano , Pesole Graziano , Tullo Apollonia , Cianfarani Stefano

Background: Children born small for gestational age (SGA) are at increased risk of coronary heart disease and type 2 diabetes in adulthood, due to reprogramming of endocrine and metabolic functions. Dysregulation of specific miRNAs in response to genetic and environmental factors contribute to aberrant gene expression patterns underlying metabolic dysfunction.Objective and hypotheses: We aimed to identify miRNAs associated with increased risk of obesity ...

hrp0082p2-d2-430 | Growth Hormone (1) | ESPE2014

A Reappraisal of the Cut-Off Limits of the Peak GH Response to Stimulation Tests for the Diagnosis of GH Deficiency in Children and Adolescents

Guzzetti Chiara , Ibba Anastasia , Pilia Sabrina , Beltrami Nadia , Di Iorgi Natascia , Rollo Alessandra , Radetti Giorgio , Zucchini Stefano , Maghnie Mohamed , Cappa Marco , Loche Sandro

Background: The diagnosis of GH deficiency (GHD) in children and adolescents is classically established when GH concentrations fail to reach an arbitrary cut-off level (usually 7–10 μg/l) after at least two provocative tests (PT).Objective and hypotheses: Aim of the study was to define optimal GH cut-offs to different PT in children and adolescent with short stature.Method: This was a retrospective study in 437 subjects w...

hrp0082p3-d2-828 | Growth (1) | ESPE2014

Growth Response After 1 Year of GH Treatment in Children Born Small for Gestational (SGA) Without GH Deficiency: our Experience

Garbetta Gisella , Pozzobon Gabriella , Osimani Sara , Damia Chiara , Ferrarello Maria Piera , Voto Andrea , Pruccoli Giulia , Partenope Cristina , Weber Giovanna , Chiumello Giuseppe

Background: Many studies have shown that GH therapy can increase final height in children born SGA. Adult height and growth velocity can be improved in these subjects even if there is not a deficiency of endogenous GH (GHD).Objective and hypotheses: We aimed to analyze growth response after 1 year of GH treatment in children born SGA without GH deficiency.Method: Ten patients (six M, four F) born SGA (according to Gagliardi et ...

hrp0084p1-73 | Fat | ESPE2015

Circulating miR146a and 486-5p are Altered in Obese Children with and Without Non-Alcoholic Fatty Liver Disease (NAFLD) and Correlate with Abdominal Fat and BMI

Montanini Luisa , Patianna Viviana D , Sartori Chiara , Predieri Barbara , Bruzzi Patrizia , Lazzeroni Pietro , Merli Silvia , Bergamaschi Paolo , Bernasconi Sergio , Iughetti Lorenzo , Street Maria Elisabeth

Background: MicroRNAs (miRNA) are small non coding RNA molecules, key regulators of metabolic pathways. Obesity is characterised by many metabolic changes. NAFLD is seen as a complication of obesity. FOXO-1, key regulator in insulin signalling, has been shown to be implicated in NAFLD. We previously identified miRNAs regulators of the FOXO-1 gene.Objective and hypotheses: To assess in serum whether the regulation of miR-146a and miR-486-5p, FOXO1 gene re...

hrp0084p2-254 | Diabetes | ESPE2015

Can We Rely on Finger Stick Haemoglobin A1c? Comparison of Levels Assayed by DCA 2000 with IFCC Reference Method in a Paediatric Cohort

Tornese Gianluca , Milic Nadia , Spetti Laura , Gembrini Daniela , Loganes Carmen , Pellegrin Maria Chiara , Radillo Lucia , Radillo Oriano , Faleschini Elena , Ventura Alessandro

Background: DCA 2000 is still a very popular device to determine HbA1c levels in diabetes practices through a finger stick. It allows clinicians to give immediate feedback to patients and to make changes in diabetes management during the three-monthly assessment.Objective and hypotheses: To compare HbA1c values measured with DCA 2000 with corresponding values measured with IFCC (considered as the reference method) in a single paediatric centre, to assess...