ESPE Abstracts

Epiphysis inhibits formation and secretion of the most pituitary hormones and at the first turn gonadotropins. Frequency of epiphysis tumors, pinealomas in children is 2.5% of all verified tumors of brain. 75% of epiphysis tumors are malignant. Endocrinological disturbances can be the first signs of pinealoma. In 10% cases there is precocious puberty syndrome. A 2.5 year-old boy presented to the endocrinology department with an 16-month history of accelerated physical developm...

Presentation of case: A 3-year-old boy with central precocious puberty as a result of the organic lesion of brain (hamartoma of hypotalamus). Complains.Increased height velocity, masculinization, fast growth of external genitalia, frequent erections, acne, low voice. Medical history. The baby was born with weight 3400 g. The age of the mother at birth of the child was 23 years. The breast feeding 6 months. In the age of 24 months boy started to grow very fastly. In the age of ...

Ectopic hormone products are typical for cancerous cells. Cancerous cells can produce ACTH, lipotropin, alfa-melanocytostimulating hormone, beta-endorfin, vasopressin, oxytocin, insuline, glucagon, gastrin, secretin, VIP, calcitonin, hypothalamic releasing-hormones, prolactin, parathyroid hormone, growth hormone, chorionic gonadotropin, growth factors. In the majority of ectopic hormone-producing tumor cases clinical symptoms are absent. This is explained by the fact that tumo...

Background: The syndrome consisting of primary hypothyroidism, precocious puberty, and massive ovarian cysts was termed Van Wyk and Grumbach syndrome (VWGS) in 1960. Chronic lymphocytic thyroiditis is the more common cause of hypothyroidism in children. In patients with severe longstanding hypothyroidism, the sella turcica may be enlarged due to thyrotrope hyperplasia. Puberty tends to be delayed in hypothyroid children in proportion to the retardation in the bone age, althoug...

Introduction: Iodine deficiency is the most common cause of mental retardation that can be prevented. The most serious consequence of iodine deficiency is cretinism. The Republic of Tuva is one of 89 administrative territories of the Russian Federation. Tuva lies in the south of Siberia and bordering Mongolia. In 1997 we first discovered the pocket of severe iodine deficiency in the Republic of Tuva and found cases of endemic cretinism. The aim: To study the features of iodine...

Background: Iodine deficiency is associated with goiter and impaired brain function. Neonatal thyroid-stimulating hormone (TSH) screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency. In the absence of iodine deficiency, the frequency of neonatal TSH above 5 mU/L whole blood is less than 3%. A frequency of 3%-19.9% indicates mild IDD. Frequencies of 20%-39.9% indicate moderate and above 40% severe IDD.The aim: to ...

Background: Neonatal diabetes (ND) at first 6 months and its frequency is one in 500 000 newborns. There are some difficulties in its treatment, due to low demand and high sensitivity to insulin.Case presentation: We present the experience in insulin pump therapy treatment. A 13 days girl was taken to Regional Children’s Clinical Hospital in Krasnodar. It was the child from the1st pregnancy with toxicosis in the one st trimester, threat of terminati...

Background: Diabetic Ketoacidosis (DKA) is a serious and common complication of type 1 diabetes mellitus. Often it occurs due to non-compliance of the patient’s insulin regimen, especially of the basal insulin. In this patient, about 6 months after being diagnosed, she presented to the emergency department in DKA, with a pH of 6.9 with altered mental status, which required intubation for 1 week. She was treated with an IV insulin drip and fluids. As a result of her manage...

Background: Consistent use of insulin pump therapy and continuous glucose monitoring (CGM) has been shown to improve glycemic control and reduce hypoglycemia.Objective and hypotheses: The aim this study compared multiple daily injection (MDI) therapy to pump insulin therapy (CSII) in children and adolescents.Method: A total of 28 children (aged 7–12) and 34 adolescents (aged 13–18) participated in this study. The particip...

Introduction: Allan-Herndon-Dudley syndrome (AHDS) is an X linked disorder – mutation of monocarboxylate transporter 8 (MCT8) gene. It leads to a severe psychomotor retardation, significant hypotonia of the skeletal muscles, spastic or dystonic quadriplegia. MCT-8 is responsible for the uptake of T3 by neurons of CNS. AHDS is characterized by increased T3 concentration, increased T3 / T4 ratio, TSH not depressed, even slightly elevated levels. Because of impossibility f...