hrp0084p3-928 | GH & IGF | ESPE2015

Acute Effects of a Training Session on IGF1 and IGFBP3 Concentrations in Brazilian Jiu-Jitsu Fighters

Filho Hugo Tourinho , Puggina Enrico , Moraes Camila , Oliveira L , Martinelli Jr Carlos

Introduction: The relationship between sports intensity and growth has become a concern in teenagers. Changes in the GH/IGF1 axis have been studied as biomarkers for training intensity in adolescents; however, reports on the effects of physical effort on GH and IGF1 levels are discordant and studies on GH and IGF1 responses in combat sports are scarce.Aim: To investigate the effects of a Jiu-Jitsu training session on serum IGF1 and IGFBP3 concentrations....

hrp0094p1-30 | Diabetes A | ESPE2021

Metabolic Control and Health-Related Quality of Life in Children with Diabetes Mellitus during the COVID-19 Pandemic: Results from a Prospective Swiss Cohort Study

Vural Serpil , Kahlert Christian , Gozzi Tiziana , Heldt Katrin , Roduit Caroline , Lauener Roger , l’Allemand Dagmar ,

Introduction: The COVID-19 pandemic led to regional lockdowns and restrictions associated with changes in lifestyle and quality of life (QoL) thus potentially burdening metabolic control in Diabetes Mellitus (DM). We examined whether the stages of restrictions lead to changes in QoL and metabolic control in children with DM.Methods: Starting in April 2020, this monocentric prospective longitudinal cohort study included c...

hrp0094p1-83 | Pituitary A | ESPE2021

Pregnancies after childhood craniopharyngioma – Results of Kraniopharyngeom 2000/2007

Sowithayasakul Panjarat , Boekhoff Svenja , Bison Brigitte , Otte Anna , Muller Hermann L. ,

Background: Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare.Study design: Observational study on pregnancy rate and outcome of offspring after CP in postpubertal, female patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000.Results: 451 CP patients (223 female) have been recruited. 269 CP patients (133 female) were postpubert...

hrp0094p1-87 | Pituitary A | ESPE2021

GHSR protects the emergence of limited sex differences in anxiety-related behaviors in adult mice after long term THC administration during peri-adolescence

Sestan-Pesa Matija , Shanabrough Marya , Horvath Tamas L. , Consolata Miletta Maria ,

As marijuana use during adolescence has been increasing, the need to understand the effects of its long-term use becomes crucial. Previous research suggested that marijuana consumption during adolescence increases the risk of developing mental illnesses, such as schizophrenia, depression, and anxiety. Ghrelin is a peptide produced primarily in the gut and is important for feeding behavior. Ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) play important...

hrp0094p1-90 | Pituitary A | ESPE2021

Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007

Boekhoff Svenja , Bison Brigitte , Eveslage Maria , Sowithayasakul Panjarat , Muller Hermann L. ,

Purpose: Childhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). We investigated clinical manifestations and outcome in incCPs and symCPs.Methods: IncCP were discovered in 4 (3m/1f) and symCP in 214 (101m/113f) CP recruited 2007–2014 in KRANIOPHARYNGEOM 2007. Age, sex, height, body mass index (BMI), tumor volume, degree of resection, pre- and postsurgical hypothalamic involveme...

hrp0094p2-283 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Assessment of genetic defects, baseline characteristics and adverse events reported in the Increlex® registry

Polak Michel , Bang Peter , Perrot Valerie , Sert Caroline , Storr Helen L. , Woelfle Joachim ,

Background: Certain genetic defects in the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis are associated with severe primary IGF-1 deficiency (SPIGFD) and short stature. Detection of genetic defects may confirm short stature aetiology alongside clinical/biochemical features. Increlex® is a recombinant human IGF-1 (rhIGF-1) approved for children/adolescents with SPIGFD.Methods: The Increlex<...

hrp0094p2-350 | Pituitary, neuroendocrinology and puberty | ESPE2021

Nuchal Skinfold Thickness in Pediatric Brain Tumor Patients

Peng Junxiang , Boekhoff Svenja , Eveslage Maria , Bison Brigitte , Sowithayasakul Panjarat , Muller Hermann L. ,

Background: Severe obesity and tumor relapse/progression have impact on long-term prognosis in pediatric brain tumor patients.Methods: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on magnetic-resonance imaging (MRI) follow-up monitoring as a parameter for assessment of nuchal adipose tissue in 177 brain tumor patients (40 World Health Organization (WHO) grade 1–2 brain tumor; 31 grade 3&#1...

hrp0094p2-363 | Pituitary, neuroendocrinology and puberty | ESPE2021

Pedigree analysis is essential for clarifying oligogenic transmission in a family with congenital hypogonadotropic hypogonadism (CHH)

Oberhauser Sarah , Papadakis G Georgios , Pitteloud Nelly , L’Allemand Dagmar ,

Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare disease with a complex clinical picture and genetic background. In up to 50% genetic mutations are found. The goal is to be able to provide a comprehensive prognosis and genetic counseling for this family with CHH.Case presentation: At the age of 16 years a boy with familial constitutional delay (adrenarche only with 15 years, no growth spurt, bone age 14 years) present...

hrp0098p1-262 | Growth and Syndromes 4 | ESPE2024

A novel comprehensive bioinformatic strategy could significantly enhance the molecular genetic diagnosis in growth restriction phenotypes

Ishida Miho , Vestito Letizia , V. Maharaj Avinaash , Cipriani Valentina , Smedley Damian , L. Storr Helen

Introduction: Growth restriction (GR) comprises ~50% of new patient referrals to paediatric endocrine clinics with <20% receiving a clear diagnosis. Enhanced genetic testing and stratification leading to tailored clinical care is a fundamental need. Whole-genome sequencing (WGS) was offered to patients recruited to the 100,000 Genomes Project (100 KGP), leading to new diagnoses in ~25% of all rare disease participants. The analysis pipeline uses disease-spe...

hrp0098p2-281 | Thyroid | ESPE2024

Autoimmune Thyroid Disease and Microalbuminuria in Adolescents

Özer Yavuz , Bingöl Aydın Dilek , Evliyaoğlu Olcay

Purpose: The aimof this study is to investigate the presence of microalbuminuria in children and adolescents diagnosed with Graves' Disease (GD) and Hashimoto's thyroiditis (HT) and compare the results with the healthy control group.Materials and Methods: This cross-sectional, single-center study included 35 patients with GH, 29 patients with HT, and 34 healthy control groups. Microalbumin and creatinine measur...