hrp0086p2-p783 | Pituitary and Neuroendocrinology P2 | ESPE2016

Basal Levels of FSH and LH can be Helpfull in Diagnosis of Puberty Precocious?

Gul Ulku , Samur Bahadir , Tatlı Zeynep Uzan , Hatipoglu Nihal , Kendirci Mustafa , Kurtoglu Selim

Background: Luteinizing hormone stimulating hormone (LHRH) test is the gold standard test in the diagnosis of puberty precocıous (PP). The basal levels of FSH (follicular stimulating hormone) and LH (luteinizing hormone) cannot be always reliable.Objective and hypotheses: To investigate the relation between the LHRH test and basal levels of FSH and LH.Method: Girls with puberty started before the age 8 are investigated. Eighty...

hrp0082p2-d2-279 | Adrenals & HP Axis (1) | ESPE2014

Genotype–Phenotype Discordant Patients with Homozygous Intron 2 Mutation (IVS2) of CYP21 Gene

Camtosun Emine , Siklar Zeynep , Ruhi Hatice Ilgin , Kutlay Nukhet Yurur , Kocaay Pinar , Tukun Ajlan , Berberoglu Merih

Background: 21-Hydroylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH) and resulted from CYP21 gene mutations. Genotype and phenotype are usually concordant. Homozygous intron 2 splice mutation (IVS2/IVS2) is frequently associated with severe enzyme deficit, and causes classical CAH. Here, we present genotype–phenotype discordant members of two different families with IVS2/IVS2 mutation.Family 1: First child of family ...

hrp0082p2-d2-336 | Diabetes (1) | ESPE2014

GAD Antibody Positivity is Associated with Higher Prevalence of Autoimmune Thyroiditis in Children with Type 1 Diabetes Mellitus

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Background: The prevalence of autoimmune thyroid disease is higher in children with type 1 diabetes mellitus (T1DM).Objective and hypotheses: The aim of this study is to compare the frequency of autoimmune thyroiditis in children with T1DM according to the presence of diabetes autoantibodies.Method: This study included 533 (49% female) children with T1DM based on hospital records from a single center. Frequency of glutamic acid dec...

hrp0082p2-d3-358 | Diabetes (2) | ESPE2014

Is There a Change in the Presentation of Childhood Type-1 Diabetes Mellitus in the Last 15 Years? Data from a Tertiary Care Center in Turkey

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Objective and hypotheses: To answer the question of whether the age of diabetes onset is shifting to younger ages and whether the rate of DKA at presentation has changed over the 15 years in children with T1DM.Method: Patients with T1DM from a single center for Pediatric Endocrinology and Diabetes in Turkey since 1999 were included. In a period of 15 years, 517 patients (249 females) were divided into three groups due to the year of diabetes diagnosed (g...

hrp0082p2-d1-451 | Growth | ESPE2014

Eleven Years of Letrozole Treatment in a Child with 11-β Hydroxylase Deficiency: Effect on Bone Age and Height Prognosis

Bereket Abdullah , Atay Zeynep , Guran Tulay , Haliloglu Belma , Abali Saygin , Bas Serpil , Turan Serap

Background: Aromatase inhibitors (AI) are being used in clinical trials in children related to peripheral precocious puberty, and idiopathic short stature to improve height prognosis.Case report: A 2 11/12 year-old boy was referred to our center for evaluation of penile enlargement and pubic hair development. Physical examination revealed a well-developed muscular boy with a body weight of 22 kg (>97p), height of 110.1 cm (>97p), with ...

hrp0082p2-d1-519 | Pituitary | ESPE2014

Hyperthyroidism Due to TSH Secreting Pituitary Adenoma in a 7-Year-Old Boy

Abali Saygin , Atay Zeynep , Haliloglu Belma , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Pituitary adenomas in childhood are 2–6% of all surgically treated pituitary adenomas at all ages. It has been estimated that TSH secretion is rare (<1% of all pituitary adenomas). Therefore, TSH secreting adenoma is very rare in childhood. Here we present the youngest patient with TSH secreting adenoma.Case: A 7-year-old boy was referred to our clinic with thyroid dysfunction by the psychiatry clinic, during his evaluation of hypera...

hrp0082p2-d1-595 | Thyroid | ESPE2014

Papillary Thyroid Cancer with Diffuse Pulmonary Metastasis: How to Manage?

Bas Serpil , Abali Saygin , Gokdemir Yasemin , Haliloglu Belma , Atay Zeynep , Karadag Bulent , Bereket Abdullah , Turan Serap

Background: Papillary thyroid cancer (PTC) is the most common endocrine malignancy in children. PTC shows more aggressive progress in children than in adults in respect to local and distant metastases. Here we presented a PTC case with primary pulmonary symptoms and pulmonary metastasis.Case: A 15.5-year-old male patient presented to the clinics with cyanosis and respiratory difficulty for the last 2 years. He had dyspnea, central cyanosis, clubbing, and...

hrp0082p3-d2-779 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Younger Age and BMI >3SD are Risk Factors for Mortality in Children with Hypothalamic Obesity

Haliloglu Belma , Turan Serap , Atay Zeynep , Guran Tulay , Abali Saygin , Bas Serpil , Bereket Abdullah

Background: Hypothalamic obesity is the most flagitious endocrinologic problem following surgical intervention for childhood brain tumors. Thus, recognition of this condition and identification of risk factors for mortality is important.Objective and hypotheses: In this study, we have shared our single center experience in obesity-related mortality in children with hypothalamic obesity.Method: We retrospectively analyzed 20 patient...

hrp0082p3-d1-930 | Puberty and Neuroendocrinology | ESPE2014

Final Height in Girls with Idiopathic Central Precocious Puberty Treated with GNRH Analog: Comparison with Untreated Controls

Atay Zeynep , Abali Saygin , Guran Tulay , Haliloglu Belma , Bas Serpil , Turan Serap , Bereket Abdullah

Background: Studies evaluating the gain in final height in patients with idiopathic central precocious puberty (ICPP) report variable outcomes and mostly lack comparison with untreated controls.Objective and hypotheses: To compare the final height of ICPP patients treated with GnRH analog with and untreated control group.Method: 48 girls with ICPP treated with GnRH analog and 52 untreated girls with ICCP (due to late referral or re...

hrp0084p2-274 | Diabetes | ESPE2015

Friedreich’s Ataxia Presenting with Diabetes Mellitus in an Adolescent

Bas Serpil , Abali Saygin , Atay Zeynep , Gurbanov Ziya , Turkdogan Dilsad , Turan Serap , Bereket Abdullah

Background: Friedreich’s ataxia (FA) is an autosomal recessive neurodegenerative disorder characterised by progressive ataxia with limb muscle weakness, absent lower limb reflexes, extensor plantar responses, dysarthria, decreased vibratory sense and proprioception. The most common molecular abnormality is a GAA trinucleotide repeat expansion in intron 1 of the frataxin (FXN) gene. Patients with FA are at risk of getting increased blood sugar levels, or ...