ESPE Abstracts

Background: In newborns, physiological transition of glucose metabolism is typically completed within 48–72 h of life, yet prolonged hyperinsulinemic hypoglycemia (HH) beyond 5d of life is not uncommonly encountered, especially in infants at-risk of hypoglycemia. Management includes intravenous dextrose while awaiting spontaneous resolution (SR) of HH or Diazoxide (DZX) therapy. Since DZX acts by suppressing insulin release, concerns arise whether weight gain in infancy w...

Background: Triglyceride and glucose (TyG) index is significantly associated with higher risk of developing type 2 diabetes mellitus (T2DM). The mechanism of the role of TyG index in the development of T2DM is not clear. There are few studies on the relationship between the TyG index and homeostatic model assessment of insulin resistance (HOMA-IR).Aims: To elucidate the role of the TyG index, studies are needed on the association between...

Background: Perturbation of inflammation is critically linked to nutrient metabolic pathways and obesity-associated complications, such as insulin resistance and type 2 diabetes (T2DM). The S100 family of proteins, including S100A8/A9 (calprotectin), have been implicated in disease pathogenesis and investigated as potential markers of inflammation. In adults, increased circulating levels of calprotectin have been reported in obesity-related chronic low-grade i...

Background: Diazoxide therapy is used as first line treatment in hyperinsulinaemic hypoglycaemia (HH). Apart from a single study reporting efficacy of low dose diazoxide in small for gestational age (SGA) infants, diazoxide has been reported to be used in doses of 5-20 mg/kg/day [1].Objective: To report the outcomes of infants with HH responsive to low dose diazoxide (≤5mg/kg/day).Method...

Background: Aspartate transaminase-to-platelet ratio index (APRI) is an easy and useful predictor of hepatic fibrosis in patients with chronic hepatic disease, and it significantly correlates with the degree of hepatic fibrosis in adult patients with non-alcoholic fatty liver disease (NAFLD).Objects: This study aimed to evaluate the use of APRI in assessing the severity of NAFLD in children and adolescents.<p class="...

Background: Recent studies suggest an association between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1). Particularly, considering the intricate interplay among α-Klotho, sex hormones, and IGF-1 during puberty, investigating α-Klotho levels in patients with central precocious puberty (CPP) could provide a deeper understanding of the significance of this protein.Methods: A total of...

Objective: To assess the effects and safety of recombinant human GH (rhGH) in GH deficient (GHD) children with Rathke cyst.Methods: The clinical data of 12 GHD children aged from 5–12 years old, whose radiologic diagnosis showed Rathke cyst during Jan 2010–Dec 2012 in our hospital, were analyzed retrospectively. rhGH was given subcutaneously to each enrolled child with a night dose of 0.1 IU/kg six to seven times a week for 12–30 months. T...

Object: To analyze the clinical and genetic characteristics of primary hypoparathyroidism in children from two children's hospitals in China.Methods: This study includes 47 patients (26 males, 21 females), who were diagnosed with primary hypoparathyroidism in Children's Hospital of Zhengzhou University and Children's Hospital of Zhejiang University School of Medicine from January 2015 to November 2022. We ...

Objective: PWS is a rare genetic imprinting disorder resulting from the expression loss of genes on the paternally inherited chromosome 15q11-13. Early-onset life-thriving obesity and hyperphagia represent the clinical hallmarks of PWS. The noncoding RNA gene SNORD116 within the minimal PWS genetic lesion plays a critical role in the pathogenesis of the syndrome.Methods: We collected inguinal white adipose tissues (ingWA...

Aims: To evaluate the performance of a factory-calibrated flash glucose monitoring system in children with diabetes compared to venous blood glucose (BG).Methods: A total of 13 hospitalized participants newly diagnosed with type 1 diabetes, aged 1~14 years old, were involved in the study. Sensor glucose measurements on days 2, 3, 6, 7, 12 and 13 of wear were compared with venous BG. During these days, the venous BG ...