hrp0097p1-11 | Adrenals and HPA Axis | ESPE2023

Girls with Premature Adrenarche but not SGA Reach Their Target Height

Bingöl Aydın Dilek , Tin Oğuzhan , Turan Hande , Bayramoğlu Elvan , Ercan Oya , Evliyaoğlu Olcay

Introduction:Premature adrenarche (PA) is the most common cause of premature pubic and axillary hair growth before the age of 8 in girls. At the time of diagnosis, the height and bone age of the cases with premature adrenarche were determined to be higher than their peers. The long-term effects of advanced bone age on the final length of the cases are controversial. In this study, it is aimed to share the long-term follow-up data of the cases diagnosed with pr...

hrp0089p2-p177 | Fat, Metabolism and Obesity P2 | ESPE2018

The Effects of the Birth Weight on the Fat Distribution and Fatness Parameters of the Body

Hatipoğlu Nihal , Direk Gul , Hepokur Merve Nur , Tatlı Zeynep Uzan , Cicek Betul , Unalan Demet , Mazıcıoğlu M. Mumtaz , Ozturk Ahmet , Kurtoğlu Selim

The weight of birth affects the weight status and fat distribution in the later period of life. It is suggested that both low and high birth weight pose a risk for cardiometabolic diseases. In this study, the effects of birth weight on body fat mass and body fat distribution parameters during childhood and adolescence period were evaluated.Method: In this cross-sectional study, 4581 children ages between 6-17 years at primary and secon...

hrp0098p3-94 | Fat, Metabolism and Obesity | ESPE2024

Real-life Experience of Liraglutide Treatment and Weight Control in Obese Adolescents: A Preliminary Study Supported by Psychoanalysis

Karakaş Hasan , Turan Hande , Güneş Kaya Didem , Sağlam Öz Yeşim , Velioğlu Haşlak Gökçe , Uçar Mert , Altun İlayda , Tarçın Gürkan , Bayramoğlu Elvan , Evliyaoğlu Olcay

Objective: The use of glucagon-like peptide-1 (GLP-1) agonists for the medical treatment of childhood obesity was approved by the FDA four years ago; however, clinical experiences are limited. In this context, our study aims to present the clinical data of obese adolescents receiving liraglutide treatment in our clinic, providing preliminary insights into its efficacy and potential benefits.Method: We retrospectively eva...

hrp0095fc6.6 | Sex Development and Gonads | ESPE2022

Breast ultrasonography: How useful in the diagnosis of precocious puberty?

Helvacıoğlu Didem , Bıyıklı Erhan , Buğdaycı Onur , Turan Serap Demircioğlu , Güran Tülay , Bereket Abdullah

Context: Assessment of breast development by physical examination(PE) can be difficult especially in overweight girls and in early stages. We aimed to study ultrasonography(USG) on evaluation of breast tissue in girls with breast development< 8 years of age.Patients and Methods: In this prospective study, 125 girls (age 7.1&pm;1.5 years) with early breast development were evaluated by breast USG for ultrasonographic b...

hrp0092p3-134 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Persistant Hypoglycemia in Children: Hyperinsulinemia

Direk Gül , Tatli Zeynep Uzan , Şiraz Ülkü , Çiçek Dilek , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Congenital hyperinsulinemia occurs due to inappropriate insulin secretion from beta cells of the pancreas. It is the most common cause of resistant and recurrent hypoglycemia in neonates and infants and the threatment is very difficult. Although the incidence is reported as 1/50000, it is seen more frequently in consanguineous countries. Patients may present with lethargy, nourishment, irritability and seizures. If it is not treated, severe hypoglycemia may result in severe ne...

hrp0089p3-p044 | Bone, Growth Plate &amp; Mineral Metabolism P3 | ESPE2018

Clinical Evaluation of Eight Patients with Parathyroid Adenoma

Direk Gul , Uzan Tatli Zeynep , Nur Hepokur Merve , Gul Şiraz Ulku , Akin Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Objective: According to the etiology of hyperparathyroidism, it is divided into primer and secondary (uremic). It usually develops due to CaSR mutation in the infancy period. On the other hand, it usually emerges secondary to a parathyroid adenoma in adolescents. Parathyroid adenomas seen in childhood are commonly associated with familial multiple neoplasia syndromes (MEN). Patients may present with bone pain, proximal myopathy, fractures, renal stone, pancreatitis or they can...

hrp0089p3-p094 | Diabetes &amp; Insulin P3 | ESPE2018

Our Clinical Experiences in Type 2 Diabetes

Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Gul Şiraz Ulku , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: Type 2 diabetes is a heterogeneous disorder characterized by the defective of insulin, which can not progressively compensate for insulin resistance, due to the influence of environmental factors on the basis of genetic susceptibility. Hyperglycemia, which starts with insulin resistance, is thought to show toxic effects (glucotoxicity) on β cells and ultimately impairs beta cell function., Although many factors play a role in etiology, obesity is the most comm...

hrp0089p3-p247 | Growth &amp; Syndromes P3 | ESPE2018

A Rare Chromosomal Disorder, Trisomy 4p

Hepokur Merve Nur , Tatlı Zeynep Uzan , Direk Gul , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: 4p duplication syndrome is a very rare chromosomal disorder. In the literature; dysmorphic facial features, learning disability, speech retardation, overgrowth, musculoskeletal abnormalities, attention deficit hyperactivity disorder and autism syndrome have been reported to be associated with 4p16.3 duplication. Here we present a patient who admitted to our clinic with complaints of growth in hands and feet along with delayed speech and mental retardation. The gene...

hrp0089p3-p297 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Is Prematüre Adrenarch Associated with Precocıous Puberty via Kisspeptin?

Albayrak Aysun , Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Aim: Premature pubarche is defined as the start of axillary and pubic hair before age 9 in boys and 8 in girls. 10 times more common in girls than boys. Central precocious puberty is a condition due to early activation of hypothalamic-pituitary- gonadal axis associated with breast development before age 8 in girls and testicular volume growth before age 9 in boys. Despite this axle is not known exactly which hormones are respnsible for the activation, the role of kisspeptin&#1...

hrp0098rfc10.1 | Multisystem Endocrine Disorders | ESPE2024

Long-Term Endocrine Outcomes of Acute Lymphoblastic Leukemia Treatment with Special Emphasis on the Gonadal Impact

Karakaş Hasan , Tarçın Gürkan , Bayramoğlu Elvan , Turan Hande , Ocak Suheyla , Evliyaoğlu Olcay , Celkan Tiraje , Apak Hilmi , Ercan Oya

Objective: Endocrine disorders following acute lymphoblastic leukemia (ALL) treatment are notable in high-risk groups and those receiving high-dose chemotherapy due to bone marrow transplantation (BMT) or relapse. This study investigates endocrine effects after ALL treatment.Methods: The study included cases diagnosed with ALL during childhood between 1995 and 2020, treated with the BFM-1995 protocol, and followed for at...