hrp0084p3-783 | DSD | ESPE2015

Impact of Neonatal Exposure to Different Doses of Bisphenol A on the Hypothalamic-Pituitary-Testicle Axis in Male Rat

Chen Lin Qi , Zhou Wen Wen , Yang Fan , Wu Hai Ying , Jin Mei Fang

Background: Male genital abnormalities may be associated with environmental endocrine disruptors.Objective and hypotheses: To observe the hypothalamic kiss-1 gene and the testis androgen acceptor (AR) gene expression level changes and the level of serum luteinizing hormone (LH), follicle stimulating hormone (FSH); testosterone (T) and Inhibin B (INH B) in neonatal rats which exposure to different doses of bisphenol-A (BPA). In order to explore the effect...

hrp0094p2-257 | Growth hormone and IGFs | ESPE2021

Investigating the impact of the TuiTek patient support programme, designed to support caregivers of children prescribed recombinant human growth hormone treatment for growth hormone deficiency in Taiwan: A pilot study

Su Pen-Hua , Lin Yen-Fan , Jheeta Amrit , Su Su-Huei , Koledova Ekaterina , Graham Selina ,

Background: Poor adherence to recombinant human growth hormone (r-hGH) treatment presents a significant barrier to achieving optimal growth outcomes. It is important to identify and address the treatment adherence-related needs of children prescribed r-hGH, and develop new approaches to improve adherence. In this study, we aimed to measure the impact of the TuiTek patient support programme, a multi-component personalised service intervention, on caregivers&#14...

hrp0097rfc6.1 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Clinical application of LH cut-off value in the diagnosis of CPP according to the international consensus

Lin Yifan , Zhang Yingxian , Fu Dongxia , Yuan Shuxian , Hou Yuwei , Wei Haiyan

Keywords: Central precocious puberty; Luteinizing hormone; Precocious puberty Gonadotropin-releasing hormone agnosit testBackground: 2019 International consensus on central precocious puberty (CPP) proposed that random serum luteinizing hormone (LH) ≥0.83IU/L and < 0.2IU/L has important reference value for the establishment or exclusion of CPP, but there is no corresponding diagnostic criteria in China. This study ...

hrp0097p1-90 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Low-Dose Diazoxide Therapy in Hyperinsulinaemic Hypoglycaemia

Yi-Lin Ng Amy , Agarwal Pankaj , Vijayan Roopa , B Arya Ved , R Kapoor Ritika , Shah Pratik

Background: Diazoxide therapy is used as first line treatment in hyperinsulinaemic hypoglycaemia (HH). Apart from a single study reporting efficacy of low dose diazoxide in small for gestational age (SGA) infants, diazoxide has been reported to be used in doses of 5-20 mg/kg/day [1].Objective: To report the outcomes of infants with HH responsive to low dose diazoxide (≤5mg/kg/day).Method...

hrp0082p1-d3-90 | Diabetes (2) | ESPE2014

The Relationship of Serum 25-Hydroxyvitamin D with Glucose Homeostasis in Obese Children and Adolescents in Zhejiang, China

Jiang You-Jun , Huang Ke , Fu Jun-Fen , Liang Jian-Feng , Zhu Hong , Zhu Zhi-Wei , Hu Li-Fei , Dong Guan-Pin , Chen Xue-Feng

Background: Evidence of the association between vitamin D, insulin resistance and oral disposition index (oDI) in obese children and adolescents is limited.Objective and hypotheses: We investigated serum 25(OH)D levels in obese children and adolescents in Zhejiang, China, and determined the relationship between serum 25(OH)D and glucose metabolism.Method: A cross-sectional design was used. All together 348 obese and 445 non-obese c...

hrp0086p1-p221 | Diabetes P1 | ESPE2016

Continuous Glucose Monitoring and Hypoglycemia Unawareness in Children and Adolescents with Type 1 Diabetes

Demir Gunay , Ozen Samim , Cetin Hafize , Darcan Sukran , Goksen Damla

Background: Seeking strict normoglycemia in type 1 diabetes mellitus increases the risk of hypoglycemia, exposing to hypoglycemia unawareness. Hypoglycemia unawareness (HU) is defined as the occurrence of hypoglycemic symptoms directly without autonomic symptoms. This study is designed to determine the incidence of HU in children and adolescents with continuous subcutaneous glucose monitoring system and to assess the effect of structured education to improve awareness.<p c...

hrp0095p1-231 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

A Case Report of Vitamin D-Dependent Rickets Type 2A Without Alopecia

Karacan Küçükali Gülin , Güleray Lafcı Naz , Savaş Erdeve Şenay , Çetinkaya Semra

Introduction: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare autosomal recessive disease that caused by mutations in the vitamin D receptor (VDR) gene. Hypocalcemia, high alkaline phosphatase, secondary hyperparathyroidism, high 1.25-OH vitamin D (1.25-OHD) levels despite normal 25-OH vitamin D (25-OHD) levels are diagnostic. The clinical signs are rickets, short stature, recurrent lung infections and total/subtotal alopecia. Here, we present a case of...

hrp0089fc2.4 | Bone, Growth Plate &amp; Mineral Metabolism 1 | ESPE2018

Diagnostic Performance of Artificial Neural Network-based TW3 Skeletal Maturity Assessment

Zhou Xuelian , Fu Junfen , Dong Guanping , Wu Wei , Huang Ke , Ni Yan , LIN Qiang , Liu Lanxuan , Ni Hao , Lai Can

Purpose: To evaluate the efficacy of supervised Artificial Neural Network (sANN) in bone age assessment and compare the diagnostic performance of sANN-based TW3 skeletal maturity assessment on hand radiographs with that of experienced child endocrinologists.Materials and methods: This study developed an optimized artificial intelligence TW3 bone age assessment system by using the sANN and rating for the 20 hand bones (13RUS+7carpal) from A to I. 8332 of ...

hrp0089p2-p113 | Diabetes &amp; Insulin P2 | ESPE2018

Detection and Analysis of Glycometabolism Related Genes in Children Diabetes

Chen Lin QI , Wang Xiao Yan , Wu Hai Ying , Chen Ting , Chen Xiu Li , Sun Hui , Wang Feng Yun

Objective: To know more about the etiology and mechanism of antibody-negative diabetes, screening MODY pathogenicity genes and deepening understanding of islet autoantibody-negative diabetes, so as to individualized precision treatment.Methods: A total of 31 subjects with diabetes who had negative islet autoantibodies and C-peptide ≥0.3 ng/ml were collected. Another group was the type 1 diabetes control group, After informed consent obtained patien...

hrp0089p3-p107 | Diabetes &amp; Insulin P3 | ESPE2018

The Value of Continuous Hemodiafiltration in Rescuing Children with Severe Diabetic Ketoacidosis

Chen Lin QI , Zhang Dan Dan , Wu Hai Ying , Chen Ting , Chen Xiu Li , Wang Feng Yun , Xie Rong Rong

Objective: To explore the value of continuous hemodiafiltration in rescuing children with severe diabetic ketoacidosis.Method: Two children with severe diabetic ketoacidosis were studied in regard to clinical manifestation, laboratory examination and treatment and of the relevant literature was reviewed.Result: Case 1 was a girl of 13 years 5 months old, who was diagnosed as ‘Type 1 diabetes mellitus, Diabetic ketoacidosis and...