hrp0084p2-337 | Fat | ESPE2015

Laparoscopic Sleeve Gastrectomy in Adolescents: Metabolic Consequences

Ybarra Marina , Franco Ruth , Cominato Louise , Velhote Manoel Carlos , Damiani Durval

Background: Severe obesity (SO), defined as BMI ≥95th percentile, has increased worldwide among adolescents. American studies estimated that 1.3–2.8% of 12–19-year-old individuals have a BMI >40 kg/m2 or a BMI >35 kg/m2 with at least one serious co-morbidity. The immediate and long-term risks associated with SO in adolescents include cardiovascular and metabolic diseases, obstructive sleep apnoea, and nonalcoholic fatty liver disea...

hrp0084p2-383 | Fat | ESPE2015

Tryptophan Supplementation as Conjunctive Therapy to Life Style Changes in Obese Adolescents

Jaramillo Adriana , Calderon Caterina , Llobet Marina , Sole Laura , Suarez-Ortega Larisa , Lerin Carles , Ramon-Krauel Marta

Background: The correlation between obesity and depression is well established. Tryptophan (Trp) is an essential amino acid that acts as substrate for serotonin and melatonin biosynthesis, both know to play a role in satiety, anxiety, and depression. Furthermore, low plasma Trp levels have been associated with obesity.Objective: To investigate the effects of Trp supplementation as a conjunctive therapy to conventional life-style intervention on weight lo...

hrp0084p3-757 | Diabetes | ESPE2015

Acute Painful Neuropathy in a Teenager with Type 1 Diabetes (T1D) and Eating Disorders

Louraki Maria , Katsalouli Marina , Kallinikou Dimitra , Kanaka-Gantenbein Christina , Kandyla Betina , Sakkou Eirini , Karavanaki Kyriaki

Background: Acute painful neuropathy (APN) is a rare manifestation of diabetic neuropathy (DN) in T1D adolescents, associated with poor metabolic control. Eating disorders (ED) often present in T1D patients in association with metabolic derangement, leading to the development of diabetic complications.Case presentation: A teenage girl aged 12 years with a recently diagnosed T1D (duration: 9 months) was admitted with diabetic ketoacidosis...

hrp0094p2-401 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Two sisters with primary hypergonadotrophic hypogonadism, pubertal progress and deletion of 61.5MB of Χq21.33q28 region

Dikaiakou Eirini , Vlachopapadopoulou Elpis Athina , Papoulidis Ioannis , Manolakos Emannouil , Vakaki Marina , Michalacos Stefanos

Objective: To present the novel finding of hypergonadotropic hypogonadism, pubertal progress and molecular alterations in two sisters with variable phenotype.Case Presentation: Two Greek sisters were investigated. The eldest was referred for investigation of short stature, at the age of 9 and 5/12 years. There was no positive family history for short stature. Physical examination revealed no dysmorphic features, and she was prepubertal according to Tanne...

hrp0094p2-477 | Thyroid | ESPE2021

L-T4 absorption test in 14-year-old patient with severe refractory hypothyroidism after total thyroidectomy

Vincenzi Gaia , Di Stefano Marina , Abbate Marco , Tarantola Giulia , Barera Graziano , Vigone Maria Cristina

Hypothyroid patients post-thyroidectomy require 1.6-1.8 mg/kg/die of Levothyroxine (L-T4). A persistent TSH level above the upper limit despite a daily dose >1.9 mg/kg/die is defined as “refractory” hypothyroidism in adults. Malabsorption and “pseudo-malabsorption” need to be investigated in case of therapeutic failure. L-T4 absorption test (LT4AT) is useful in distinguishing these two conditions but it has only been described in adult age. We ...

hrp0094p2-55 | Adrenals and HPA Axis | ESPE2021

Twin infants with salt-wasting: double the trouble

Graneiro Ana , Aguilar Abisad Daniela , Dantas Marina , Gonzalez Aragon Camila , Tarkoff Joshua ,

Introduction: Failure to thrive (FTT) is a common entity encountered by pediatricians. It can be caused by inadequate energy intake or “organic causes” such as inborn errors of metabolism or disorders of the endocrine system. One cause that is rarely seen is a deficiency of aldosterone.Case presentation: A set of 3-month-old monozygotic male twins presented with failure to thrive and dehydration. Initially, they were evaluated ...

hrp0094p2-138 | Diabetes and insulin | ESPE2021

Correlation between antiinsulin autoantibodies and clinical presentation in T1DM

Sukarova-Angelovska Elena , Jakimovska Anastasija , Krstevska-Konstantinova Marina , Brnjarchevska-Blazevska Teodora , Sibinovska Olgica ,

Introduction: The pathogenetic process in type 1 diabetes mellitus includes a complex mechanism between genetic and immunological factors. Chronic autoimmune reaction relies upon the detection on autoantibodies in the patient’s serum long before initiation of the disease. Autoimmune markers include mainly 4 types of antibodies - GAD65, IAA, ICA and IA-2, some present in children less than 10 years (IAA, ZnT8), and some later in life (GAD, IA-2).The presen...

hrp0094p2-185 | Fat, metabolism and obesity | ESPE2021

A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program is Associated with Increased Leukocyte Telomere Length in Children and Adolescents with Overweight and Obesity

Paltoglou George , Raftopoulou Christina , Nicolaidis Nicolas , Genitsaridi Sophia , Karabatsou Sophia , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia ,

Background/Aim: Leucocyte telomere length (LTL) is a robust marker of biological aging and is associated with obesity and cardiometabolic risk factors even in childhood and adolescence. The aim of the present study was to assess the effect of a structured, comprehensive, multidisciplinary, personalized, lifestyle intervention program of healthy diet and physical exercise on LTL in children and adolescents with overweight and obese.Materi...

hrp0094p2-205 | Fat, metabolism and obesity | ESPE2021

Assessment of cardiometabolic risk factor clustering in obese children and adolescents with metabolic syndrome

Tragomalou Athanasia , Manou Maria , Loukopoulou Sofia , Binou Maria , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia ,

Background: Obesity in childhood and adolescence has reached epidemic proportions. Endothelial dysfunction, as a consequence of dyslipidemia, hypertension, insulin resistance and inflammation, imposes a substantial risk for the development of metabolic syndrome (MS) in childhood and compromises the health of the pediatric population by promoting premature development of atherosclerotic cardiovascular disease.Aim: To inve...

hrp0097p1-252 | Fat, Metabolism and Obesity | ESPE2023

Dietary and physical activity habits of children and adolescents after a personalized intervention for the management of obesity

Ioannou Georgia , Petrou Ioulia , Manou Maria , Papadopoulou Marina , Tragomalou Athanasia , Kassari Penio , Charmandari Evangelia

Introduction: Obesity in childhood and adolescence has been recognized by the WHO as a global epidemic and a major public health problem. Greece, is one of the main countries in Europe where the problem of childhood obesity has increased rapidly. This rise can be attributed to dietary and physical activity risk factors. Recently, there has been a need for a detailed recording and assessment of the lifestyle habits of children and adolescents receiving personal...