hrp0095p1-475 | Fat, Metabolism and Obesity | ESPE2022

The Impact of Acute Exercise on 12,13-Dihydroxy-9Z-Octadecenoic Acid (12,13-DiHOME) Levels in Male Adolescents with Obesity

Ercan Oya , Gurup Aybüke , Tarçın Gürkan , Yakal Sertaç , Turan Hande , Şahinler Ayla Sibel , Boztürk Güngör Zeynep

Aim: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a lipokine secreted from brown adipose tissue, and it is shown to have positive effects on dyslipidemia. Acute exercise have been shown to lead to an increase in its secretion. It was aimed to investigate the relation of 12,13-diHOME with obesity, exercise and dyslipidemia for the first time in the adolescent age group.Methods: This is a prospective study includ...

hrp0095p1-396 | Thyroid | ESPE2022

A rare cause of acquired von Willebrand factor deficiency: Primary hypothyroidism due to autoimmune thyroiditis

Dağdeviren Çakır Aydilek , Yıldız Yıldırmak Zeynep , Eren Simge , Mısırlı Özdemir Ebru , Özdemir Mustafa , Ucar Ahmet

In children, autoimmune thyroiditis is often diagnosed with signs and symptoms such as goiter, short stature, and constipation. Delayed diagnosis of hypothyroidism may result in atypical signs and symptoms at presentation, depending on the severity of hypothyroidism. Von Willebrand disease (vWD) is the most common bleeding disorder caused by the quantitative or qualitative deficiency of von Willebrand factor (vWF). Acquired vWD (avWD) is a disorder characterized by low levels ...

hrp0095p1-591 | Thyroid | ESPE2022

Evaluation of Permanent and Transient Congenital Hypothyroidism in Cases Referred from National Neonatal Screening Program

Donbaloğlu Zeynep , Çetinkaya Semra , Aycan Zehra , Karacan Küçükali Gülin , Şakar Merve , Savaş Erdeve Şenay

Objective: The incidence of congenital hypothyroidism (CH) has increased worldwide. Lowering cut-off in screening programs has led to an increase in the rate of transient CH. We aimed to evaluate the rates of permanent and transient CH in cases referred from the screening program and to investigate the clinical and laboratory factors to predict the transient CH.Methods: 109 cases referred from the screening program to ou...

hrp0092p1-402 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Evaluation of Brain Mri Lesions in 381 Girls with Central Precocious Puberty

Helvacioglu Didem , Guran Tulay , Kirkgoz Tarik , Atay Zeynep , Abali Zehra Yavas , Eltan Mehmet , Kaygusuz Sare Betul , Seven Tuba , Gurpinar Busra , Turan Serap , Bereket Abdullah

Central precocious puberty (CPP) in girls is a diagnosis increasingly made by the Pediatric Endocrinologists worldwide. Although it is most frequently of idiopathic origin, magnetic resonance imaging (MRI) of the brain is recommended to rule out organic lesions causing CPP. However, controversy exists regarding the age limits for routinely performing MRI in girls with CPP.Objective: To evaluate the outcome of brain MRI in girls diagnosed...

hrp0092p3-134 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Persistant Hypoglycemia in Children: Hyperinsulinemia

Direk Gül , Tatli Zeynep Uzan , Şiraz Ülkü , Çiçek Dilek , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Congenital hyperinsulinemia occurs due to inappropriate insulin secretion from beta cells of the pancreas. It is the most common cause of resistant and recurrent hypoglycemia in neonates and infants and the threatment is very difficult. Although the incidence is reported as 1/50000, it is seen more frequently in consanguineous countries. Patients may present with lethargy, nourishment, irritability and seizures. If it is not treated, severe hypoglycemia may result in severe ne...

hrp0089p3-p044 | Bone, Growth Plate & Mineral Metabolism P3 | ESPE2018

Clinical Evaluation of Eight Patients with Parathyroid Adenoma

Direk Gul , Uzan Tatli Zeynep , Nur Hepokur Merve , Gul Şiraz Ulku , Akin Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Objective: According to the etiology of hyperparathyroidism, it is divided into primer and secondary (uremic). It usually develops due to CaSR mutation in the infancy period. On the other hand, it usually emerges secondary to a parathyroid adenoma in adolescents. Parathyroid adenomas seen in childhood are commonly associated with familial multiple neoplasia syndromes (MEN). Patients may present with bone pain, proximal myopathy, fractures, renal stone, pancreatitis or they can...

hrp0089p3-p094 | Diabetes & Insulin P3 | ESPE2018

Our Clinical Experiences in Type 2 Diabetes

Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Gul Şiraz Ulku , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: Type 2 diabetes is a heterogeneous disorder characterized by the defective of insulin, which can not progressively compensate for insulin resistance, due to the influence of environmental factors on the basis of genetic susceptibility. Hyperglycemia, which starts with insulin resistance, is thought to show toxic effects (glucotoxicity) on β cells and ultimately impairs beta cell function., Although many factors play a role in etiology, obesity is the most comm...

hrp0089p3-p247 | Growth & Syndromes P3 | ESPE2018

A Rare Chromosomal Disorder, Trisomy 4p

Hepokur Merve Nur , Tatlı Zeynep Uzan , Direk Gul , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Background: 4p duplication syndrome is a very rare chromosomal disorder. In the literature; dysmorphic facial features, learning disability, speech retardation, overgrowth, musculoskeletal abnormalities, attention deficit hyperactivity disorder and autism syndrome have been reported to be associated with 4p16.3 duplication. Here we present a patient who admitted to our clinic with complaints of growth in hands and feet along with delayed speech and mental retardation. The gene...

hrp0089p3-p297 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Is Prematüre Adrenarch Associated with Precocıous Puberty via Kisspeptin?

Albayrak Aysun , Direk Gul , Uzan Tatlı Zeynep , Nur Hepokur Merve , Akın Leyla , Hatipoğlu Nihal , Kendirci Mustafa , Kurtoğlu Selim

Aim: Premature pubarche is defined as the start of axillary and pubic hair before age 9 in boys and 8 in girls. 10 times more common in girls than boys. Central precocious puberty is a condition due to early activation of hypothalamic-pituitary- gonadal axis associated with breast development before age 8 in girls and testicular volume growth before age 9 in boys. Despite this axle is not known exactly which hormones are respnsible for the activation, the role of kisspeptin&#1...

hrp0086rfc9.5 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016

Non-Mody Monogenic Diabetes: A Very Heterogenous and Problematic Group of Diabetes

Siklar Zeynep , De Franco Elisa , FlanagaN Sarah , Ellard Sian , Ceylaner Serdar , Boztug Kaan , Dogu Figen , Ikinciogullari Aydan , Kuloglu Zarife , Kansu Aydan , Berberoglu Merih

Background: Monogenic diabetes represents a group of disorders resulting from a single gene defect leading to disruption of insulin secretion or a reduction in the number of beta cells. Despite the classification of monogenic diabetes according to age of onset, with neonatal DM (<6 months of age) and maturity onset diabetes of young (MODY) (>6 months and <25 years of age); not every case can be classified into those groups.Objective and hypot...