ESPE Abstracts

Keywords: Human Leukocyte Antigen system, DRB1 allelesDiabetes mellitus is one of the diseases, the genetics of which has been most widely studied. In 40-50 % cases it is connected with Human Leukocyte Antigene system. The major genetic deterninants of this disease are DQ and DR genes "DR3" and "DR4" haplotypes create high risk for diabetes.Insulin dependent diabetes mellitus risk is very high a...

Influence of anthropometric indices at birth on obesity characteristics in school-age children Latyshev D. Yu., Lobanov Yu. F.? Latyshev O. Yu. *, Karkova T.A. Altai State Medical University, Barnaul * Russian Medical Academy of Postgraduate Education. Moscow Keywords: obesity, children, body length, body mass index Objective: To study the relationship between anthropometric data at birth and the course of obesity in school-age children. Materials and metho...

Objectives: To determine the presence of depressive disorders in adolescents with T1DM, SCA, and HIV/AIDS being managed in UPTH and to compare the scores between the various diseases.Method: A cohort study of 75 children (20 T1DM, 26 SCA, and 29 HIV/AIDS) presenting to the Department of Paediatrics, UPTH between 1stof October 2018 and 31stof May 2019 had an interviewer administered Beck depression i...

Background: While differences in gut microbiota between obese and lean subjects have been described, few studies have examined how adiposity across childhood relates to intestinal microbiota composition and diversity in late adolescence.Objective: To explore the correlations between measures of adiposity from childhood and adolescence with intestinal microbiota composition and diversity at 15–17 years.Methods: Data stem from t...

Introduction: Type 1 diabetes mellitus (1DM) has well known long term vascular and neuropathic complications. It has also been described a positive effect of good glycemic control on physical growth and pubertal development, achieved with improvement of insulin-therapy.Aim: To evaluate the effect of functional insulin-therapy on final height in children with type 1 diabetes mellitus.Methods: Retrospective analysis of a cohort of po...

Background: Brain-derived neurotrophic factor (BDNF) plays a role in the central regulation of energy balance and has been associated with body mass index (BMI).Objective: The aim of this study was to investigate potential differences in serum BDNF concentrations in adolescents by gender and BMI, as well as possible correlations of circulating BDNF with the adolescents’ characteristics of metabolic syndrome.Methods: Study part...

Objective: This study is to evaluate the association among plasma adropin, leptin, lipopolysaccharide-binding protein (LBP) levels and lipid characteristics in children with obesity.Methods: This was a cross-sectional study of children with obesity ranging from 5.5 to 12.5 years old, and age- and gender-matched children with normal weight were collected as control. Height, weight, waist circumference and hip circumference of all the participants were mea...

Obese children are at risk for increased DHEAS production, which is assumed to arise from hyperinsulinemia, hyperleptinemia, increased IGF-1 production or chronic low grade inflammation. Exaggerated adrenarche is suspected to be a forerunner of polycystic ovary syndrome in girls, but its consequences in obese boys are less well studied. In this study we evaluated the presence of exaggerated adrenarche in a cohort of obese boys and girls and investigated whether obese children ...

Background: Childhood obesity is associated with non-alcoholic fatty liver disease (NAFLD). Previous studies in obese adult and pubertal children with NAFLD have shown that chronic inflammation/oxidative stress and insulin resistance might induce iron metabolism disorders, characterized by increased Hepcidin and Ferritin levels and decreased serum Iron levels. However, data evaluating these findings in a well selected population of obese prepubertal children are still missing....

Introduction: Growth hormone (GH) deficiency is diagnosed through the combination of clinical observation and low GH upon stimulation, in two separate stimulation tests. Normal response is considered as a single rise of GH above the local cutoff point which is used, and differs between countries and range between 7–10 mcg/L. The aim of our study was to assess whether a calculation of area under the curve (AUC) of GH can be used as an additional tool in the diagnosis of GH...