ESPE Abstracts

Background: The relationship of obesity and emotional disorders is confirmed in many studies. It is known that one of the substances responsible for the emotional status is dopamine.Objective: To study the features of neuroendocrine status in obese children.Methods: We examined 285 children (206 obese, age 14.56±2 years, BMI 32.86±5.1 kg/m2; 79 normal weight (control), 14.51±2.2 years (P=0.95), 19...

Objectives: The purpose of the study is to assess the levels of myokine irisin and adipocytokine leptin in SGA newborns, to analyze the relationship between the parameters of the hormonal status of children and their mothers.Materials and Methods: 49 mother-newborn pairs were examined. Two groups of full-term newborns were distinguished. Group 1 (Gr1) - small for gestational age (body weight (BW) at birth 10th percentile...

Background: Body image (BI) is subjective picture of one’s own physical appearance established both by self-observation and by noting the reactions of others. Different BI scales used for screening of the Binge Eating symptoms that strongly linked to obesity.Objective and hypotheses: We supposed to get differences in the own body image perception in overweight and lean children.Method: BI questionnaire (BIQ) and own body satis...

Background: Primary and secondary prevention of childhood obesity is an essential public health priority.Objective and hypotheses: To determine relationships between families, genetic and metabolic obesity risk factors in children.Method: 782 children (204 lean/578 obese; m/f=414/368) aged from 2 to 17.9 years were examined and classified in line with the pubertal stage: 392 prepubertal, 141 early, and 249 late puberty. Family hist...

Background: Increased caloric intake in dietary obesity (DO) could be driven by central mechanisms regulating reward-seeking behavior. Leptin modulates the mesolimbic dopamine system and vice versa.Objective and hypotheses: We supposed D2 dopamine receptor agonists to influence weight gain and leptin level in genetically unmodified rats (GUR) with high caloric diet (HCD) as dietary obesity.Method: Male rats (n=48,...

Background and aim: High caloric diet (HCD) in diet-induced obesity (DIO) can be caused by central mechanisms regulating reward-seeking behaviour. Leptin modulates the dopamine system and vice versa. We supposed D2 dopamine receptor agonist and dopamine neurons toxin to influence weight gain and leptin level, mobility and behaviour in wild type rats (GUR) with HCD.Materials and methods: Male rats (n=64, 183.0±14.0 g) were divided into HCD g...

Background: In recent years a special interest of researchers is focused on questions related to the early stages of the formation of food behavior (FB), considering their close connection with socially significant problems of the present - obesity, metabolic syndrome, cardiovascular pathology, etc.Aims: To assess the characteristics of the children’ nutritional behavior, taking into account the level of physical development at birt...

Background: Severe insulin resistant (IR) type A is a rare inherited disorder characterized by glucose metabolism disturbances without obesity, acanthosis nigricans and hyperandrogenia due to INSR defects.Case report: A 10-year-old girl was admitted because of skin papillomatosis and hyperpigmentations since her 7 years. She had early puberty with pubarche at 8 years and telarche at 9 years. Examination revealed normal height and weight (SDS BMI...

Objective: Transsphenoidal surgery (TSS) is a treatment of choice for Cushing`s disease (CD), whose effectiveness range is from 70 to 90%. Recurrence rate after successful treatment is about 25%. Preoperative predictors of remission and recurrence are still unexplored what leads to further investigations.Aim: Analysis of remission and recurrence rates of CD after radical treatment according to preoperative MRI....

Objective: To evaluate the response to recombinant human GH (rhGH) treatment in NS children with short stature and previously identified mutations in the RAS/MAPK pathway genes.Methods: 23 patients with NS (17 males; 19 PTPN11, 3 RAF1 e 1 SHOC2) were daily treated with rhGH (mean rhGH dose of 47 μg/kg per day). The main outcome measures were 1st year growth velocity, change in height SDS (Noonan syndrome specifi...