hrp0086p1-p235 | Diabetes P1 | ESPE2016

The Genetic Causes and Phenotypic Characteristics of Egyptian Patients with Neonatal Diabetes Mellitus

Elkaffas Rasha , Musa Noha , Franco Elisa De , Madani Hanan A , Shaalan Yomna , El-Kaffas Rania M.H. , Hassan Mona , Hafez Mona , Kholi Badawy El , Flanagan Sarah E , Ellard Sian , Hussain Khalid

Background: Neonatal Diabetes Mellitus (NDM) is a rare form of monogenic diabetes that typically presents during the first 6 months of life. Its prevalence is about 1:100 000 live births; however it may rise up to 1:29 000 in highly consanguineous populations. Mutations in 22 different genes are reported; with the most common cause being potassium channel subunit gene (KCNJ11/ABCC8) mutations. However, causative mutations among consanguineous populations seem to diffe...

hrp0084p2-286 | Diabetes | ESPE2015

Assessment of Ventricular Function by Tissue Doppler Echocardiography in Children and Adolescents with Type 1 Diabetes Mellitus

Abdelghaffar Shereen , Salah Nermeen , Attia Mona , Hafez Mona , Mamdouh Mona , Atef Abeer , Elmougy Fatma , Abdelaty Sahar , Ibrahim Amany , Mehawed Hend , Musa Noha , Arafa Noha , Farouk Marwa , Ismail Mohamed , Abdelaziz Faten , Fattouh Aya , Hussein Eman , Ghali Isis

Background: Tissue Doppler echocardiography can predict early stages and progression of diabetic cardiac changes; especially ventricular dysfunction, a complication that adversely affect the quality of life and prognosis of the disease.Objective and hypotheses: The aim of this study was to assess systolic and diastolic functions of both ventricles in type 1 diabetes (T1D) patients by conventional and Tissue Doppler echocardiography, and to correlate card...

hrp0092lb-8 | Late Breaking Posters | ESPE2019

Detection of Cardiomyopathy in Egyptian Children and Adolescents with Longstanding Obesity Using Cardiac Marker NT-pro PNB and Speckled Tracking Echocardiography

Hafez Mona , Musa Noha , Fakhry Antoine , ELMougy Fatma , ELShennawy Hala

Introduction: Obesity is considered a major risk factor for developing cardiovascular morbidity and mortality. Obesity affects the structure and function of the heart mainly by causing increased blood volume, elevated cardiac output, left ventricular (LV) hypertrophy, and LV diastolic dysfunction. All of which can play a role in causing heart failure.Objective: This cross-sectional study aimed to evaluate the effect of l...

hrp0089p1-p091 | Diabetes & Insulin P1 | ESPE2018

Screening for T2D in High Risk Egyptian Children and Adolescents Using Strip HbA1c and OGTT

Hafez Mona , Musa Noha , Mansour Mona , Hamdy Heba

Background: The prevalence of type 2 diabetes (T2D) is significantly increased in pediatric population, which is affected by obesity worldwide. The progression of insulin resistance to T2D in obese children has been shown to be faster than in adults. Therefore, screening for T2D seems meaningful especially in high risk groups such as children and adolescents with obesity, family history of T2D, and those with clinical features of insulin resistance (hypertension, dyslipidemia,...

hrp0089p2-p078 | Diabetes & Insulin P2 | ESPE2018

Protein and Fat Effects on Post - Prandial Glucose Responses among Egyptian Children and Adolescents with Type 1 Diabetes Mellitus

Arafa Noha , Hafez Mona , Anwar Ghada , Abdou Marise , Ibrahim Rania

Background: In the light of emerging recent researches and the use of continuous glucose monitoring it was shown that other nutritional properties of food, including fat, protein, and glycemic index (GI), can significantly affect postprandial glucose excursions. These findings highlight the need for alternative mealtime insulin dosing algorithms and have important implications for nutrition education and counseling in patients with diabetes.Objective and...

hrp0086p1-p240 | Diabetes P1 | ESPE2016

Effect of Vitamin D Supplementation on Lipid Profile in Vitamin D Deficient T1D Patients with Dyslipidemia

Hafez Mona , Musa Noha , Sharaf Sahar , Wahab Nehal Abdel

Background: It was suggested that vitamin D has both direct and indirect effects on modifying the lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity.Objective and hypotheses: To detect the relationship between serum 25(OH) D and lipid profiles in patients with T1D and dyslipidemia and to study the effect of vitamin D supplementation on lipid profiles of vitamin D deficient ...

hrp0082p3-d1-633 | Adrenals & HP Axis | ESPE2014

Steroid 11β Hydroxylase Deficiency in Egyptian Children

Musa Noha , Ghali Isis , Farag Sara , Amin Maha , Hafez Mona

Background: Congenital adrenal hyperplasia (CAH) is one of the most common inherited endocrinal disorders. Steroid 11β hydroxylase deficiency (11βOHD) is the 2nd most common form of CAH. It is a rare AR disorder caused by CYP11B1 mutations with an incidence of 100 000–200 000 in overall population.Objective and hypotheses: To detect 11β hydroxylase deficiency in patients presenting with clinical manifestations and hormonal findings su...

hrp0084p3-745 | Diabetes | ESPE2015

Vitamin D Status in Egyptian Children with T1D and the Role of Vitamin D Replacement on Glycaemic Control

Hafez Mona , Hassan Mona , Sharaf Sahar , Musa Noha , Sameh Sally

Background: Many epidemiological studies have found high prevalence of vitamin D deficiency in children with type 1-diabetes mellitus (T1D). 1,25(OH)2D is a potent immune-modulator that also enhances the production and secretion of several hormones, including insulin. The association of low serum 1,25(OH)2D levels with high glucose level and diminished insulin sensitivity suggests that vitamin D may modulate insulin metabolism.Aim and objectives: To scre...

hrp0082p2-d2-331 | Diabetes (1) | ESPE2014

ACE Gene Insertion/Deletion Polymorphism and ACE Enzymatic Activity in Egyptian Children with Type 1 Diabetes with and without Microalbuminuria

Anwar Ghada , Bazaraa Hafez , Shaker Olfat , Arafa Noha , Hafez Mona , Mousa Noha

Background: Diabetic nephropathy is a major cause of morbidity and mortality among young adults with type 1 diabetes mellitus. Strong evidence exists in multiple studies for genetic predisposition of diabetic nephropathy. Genetic studies have revealed that the genes for the renin–angiotensin system (RAS) are highly polymorphic, one of such is insertion/deletion polymorphism in ACE gene. This polymorphism was associated with the circulating ACE level and increased plasma a...

hrp0084p3-856 | Fat | ESPE2015

Relationship between Visceral Obesity and Plasma Fibrinogen in Obese Children

Hafez Mona , Masry Sahar El , Musa Noha , Fathy Marwa , Hassan Mona , Hassan Nayera , Tareef Mahmoud , Husseiny Mohamed El

Background: The prevalence of obesity in children and adolescents has increased significantly worldwide with an alarming rise of its co-morbidities. The excess of visceral adipose tissue is associated with hypertension, prothrombotic and pro-inflammatory states leading to cardiovascular diseases.Aim of the study: To find possible associations between visceral obesity and plasma fibrinogen, as one of the cardiovascular risk factors, in obese children....