hrp0098p1-134 | Fat, Metabolism and Obesity 2 | ESPE2024

The prevention of childhood obesity is a priority: preliminary results of the "EpPOI: Education to Prevent Childhood Obesity" project

Anna Morabito Letteria , Porri Debora , La Rosa Elisa , Corica Domenico , Pepe Giorgia , Francesca Messina Maria , Valenzise Mariella , Aversa Tommaso , Wasniewska Malgorzata

Introduction: Rapidly rising rates of childhood obesity (CO) are a current problem, and European and national data confirm the concern. CO comorbidities occur early and tend to persist into adulthood, negatively affecting long-term health. There is an urgent need to implement CO prevention programs, starting in the early years of life. In Southern Italy, an innovative health project, “EpPOI: Educate to Prevent Childhood Obesity,” has been establish...

hrp0098p2-376 | Late Breaking | ESPE2024

Central Precocious Puberty and MKRN3 variants: new insights into the protein RING finger structure, and on protein ubiquitination and localization

Bencivenga Debora , Stampone Emanuela , Palumbo Stefania , Hafiz Ali Akbar , Cirillo Grazia , Aiello Francesca , Miraglia del Giudice Emanuele , Borriello Adriana , Grandone Anna

Background: MKRN3 (Makorin Ring Finger Protein 3) is a maternally imprinted intronless gene located in the Prader-Willi syndrome locus (chromosome 15q11.2-q13). It is recognized that MKRN3 loss-of-function mutations are the primary cause of familial central precocious puberty (CPP). The MKRN3 protein primarily acts as an E3 ubiquitin ligase, and its activity is essential for controlling the timing of puberty, functioning as a brake on gonadotropin-releasing ho...

hrp0089p1-p113 | Fat, Metabolism and Obesity P1 | ESPE2018

Maternal Resveratrol Intake During Pregnancy and Lactation Modulates the Long-term Metabolic Effects of Maternal Nutrition on Offspring Depending on the Sex and Diet

Ros-Perez Purificacion , Diaz Francisca , Freire Alejandra , Argente-Arizon Pilar , Argente Jesus , A. Chowen Julie

Maternal nutrition can have significant long-term consequences on energy homeostasis in the offspring. However, whether resveratrol, with antioxidant and anti-obesity actions, can improve the impact of poor maternal nutrition on offspring metabolism remains largely unknown. We hypothesized that resveratrol intake by dams would protect the offspring against the harmful effects of a maternal high fat diet (HFD). We also determined if resveratrol’s effects are diet and sex d...

hrp0089p1-p140 | Fetal, Neonatal Endocrinology and Metabolism P1 | ESPE2018

Sexual Dimorphism of IGF1 and IGF2 Expression in the Neonatal Rat Brain

Guerra-Cantero Santiago , Torrecilla Marta , Diaz Francisca , Argente Jesus , Chowen Julie

Insulin-like growth factor (IGF) 2 plays a fundamental role in prenatal growth and development. The IGF2 gene is imprinted, with the paternally inherited copy being active and the maternal copy being silenced in most tissues. During development, the expression of IGF2 is sexually dimorphic in some tissues and this is thought to be involved in the development of some sexually dimorphic features. For example, IGF2 expression is reported to be higher in the male brain co...

hrp0086p1-p227 | Diabetes P1 | ESPE2016

Rising of Type 1 Diabetes Mellitus Incidence in Chilean Children Between 2006 and 2014

Garfias Carolina , Garcia Hernan , Ugarte Francisca , Martin Yonathan San , Bortzuski Arturo , Cerda Jaime

Background: T1DM incidence in children varies across regions and countries, showing a continue rise Worldwide.Objective and hypotheses: To determine the incidence of T1D in Chilean children under 20 years between 2006 and 2012.Method: We reviewed mandatory notifications of T1D (GES Program) in Chile’s public health system in population younger than 20 years between 2006 and 2014. Data were obtained from the Department of Infor...

hrp0086p1-p447 | Fat Metabolism and Obesity P1 | ESPE2016

Neonatal Overnutrition Causes Sex and Age Dependant Long-Term Effects on Body Weight, Body Composition and Serum Triglyceride and Free Fatty Acid Levels

Argente-Arizon Pilar , Diaz Francisca , Fuente-Martin Esther , Chowen Julie Ann , Argente Jesus

Background: Neonatal over-nutrition (NON) can increase the propensity to become overweight and develop associated metabolic disturbances in later life. Moreover, some of these long-term effects are sexually dimorphic.Objective and hypotheses: We aimed to determine how NON affects body weight (BW), body composition and triglyceride (TG) and non-esterified fatty acids (NEFA) levels. We hypothesized that the effects would be both age and sex dependant.<...

hrp0086p2-p848 | Syndromes: Mechanisms and Management P2 | ESPE2016

Growth of Children Born Preterm During the First 8 Years of Life

Cardoso-Demartini Adriane , da Silva Regina Cavalcante , de Lara Francisca , Boguszewski Margaret

Background: Approximately 15 million children are born preterm worldwide yearly.Objective and hypotheses: To evaluate spontaneous growth during the first 8 years of life.Hypotheses: Preterm born children have spontaneous recovery of weight and height in the first 8 years of life.Method: Measurements at birth, 6, 12 and 24 months of corrected age and at recall [6.4±0.5 years (5.2–8.0)]. Weight, lengt...

hrp0082fc12.1 | Obesity | ESPE2014

High-Fat Diet Rapidly Triggers Circadian De-Synchronization of Clock Genes, Neuropeptides and Inflammation Mediators in the Hypothalamus of C57BL Mice

Hernandez-Nuno Francisco , Ruiz-Gayo Mariano , Diaz Francisca , Argente Jesus , Chowen Julie A

Background: Circadian disorganization of feeding behavior evoked by high fat diet (HFD) intake is suggested to be involved in the resulting weight gain and development of associated metabolic alterations and hypothalamic inflammation.Hypothesis: We hypothesized that this circadian alteration might be a consequence of rapid de-synchronization of different gene clusters relevant for metabolic control.Methods: We analyzed the circadia...

hrp0082p1-d1-110 | Fat Metabolism &amp; Obesity | ESPE2014

Free Fatty Acids Activate Hypothalamic Astrocytes in a Sexually Dimorphic Manner

Argente-Arizon Pilar , Fuente-Martin Esther , Diaz Francisca , Freire-Regatillo Alejandra , Argente Jesus , Chowen Julie A

Introduction: Obesity is known to associate with chronic systemic inflammation. However, hypothalamic inflammation also occurs in response to high fat diet (HFD)-induced obesity and is proposed to participate in central insulin/leptin resistance and the perpetuation of weight gain and systemic affectation. The weight gain and central responses to HFD differ between males and females. As hypothalamic glial cells are implicated in the central inflammatory response we hypothesize...

hrp0084p3-859 | Fat | ESPE2015

Long-Term Effects of Neonatal Over-Nutrition on Metabolic Equilibrium are Age and Sex Dependant

Argente-Arizon Pilar , Ros Purificacion , Diaz Francisca , Fuente-Martin Esther , Barrios Vicente , Chowen Julie A , Argente Jesus

Background: Neonatal over-nutrition (NON) can have a long-term effects on energy homeostasis and some of these effects may be sexually dimorphic.Objective and hypotheses: We aimed to determine how NON affects body weight (BW), body composition and cytokine levels throughout development and if these changes are sexually dimorphic. We hypothesised that the effects would be both age and sex dependant.Methods: At birth, Wistar rats wer...