hrp0084p2-297 | Diabetes | ESPE2015

GH Promotes mRNA Expression and Secretion of Progranulin in 3T3-L1 Cells

Song Guo , Hongshan Chen , Jun Zhang , Minlian Du , Huamei Ma , Yanhong Li , Qiuli Chen , Yangshui Peng

Background: Recently, progranulin (PGRN) was a novel adipokine which is a key adipokine insulin resistance in adipose tissue. While GH was closely related to glucose metabolism and insulin resistance.Objective and hypotheses: We suspected that there maybe some positive relationship between GH and PGRN. Our study was to detect expression and regulation of PGRN in mouse 3T3-L1 cells follow the treatment with GH.Method: The mRNA was m...

hrp0097p2-162 | GH and IGFs | ESPE2023

Correlation between IGF-1 at diagnosis and adult height in children with short stature

Incandela Valeria , Lussu Anna , Guzzetti Chiara , Ibba Anastasia , Loche Sandro , Casula Letizia

Background: Insulin-like Growth Factor-1 (IGF-1) is an amino acid peptide produced under the effect of Growth Hormone (GH), mostly secreted by the liver, which stimulates bone growth. IGF-1 levels have high specificity and low sensitivity for the diagnosis of Growth Hormone Deficiency (GHD). Higher IGF-1 levels are classically associated with a better response to growth hormone therapy. The aim of this study was to investigate the correlation between serum IGF...

hrp0089p2-p092 | Diabetes & Insulin P2 | ESPE2018

Hypertriglyceridemia in Type 1 Diabetes Children During Diabetic Ketoacidosis; Relation to DKA Severity and Glycemic Control

Fawaz Lubna , Musa Noha , AbdelAtty Sahar , Nassef Ahmed

Background: Diabetic ketoacidosis (DKA) is a common, life-threatening complication of type 1 diabetes (T1D). Insulin deficiency impairs lipoprotein lipase (LPL) resulting in elevated serum triglycerides (TG) that usually normalize after establishing IV insulin.Objectives: To study the prevalence of hypertriglyceridemia during DKA in T1D patients and assess its relation to DKA severity and glycemic control after 3 months.Methodology...

hrp0086p1-p250 | Diabetes P1 | ESPE2016

Type 1 Diabetes (T1D) Management with Few Blood Glucose (BG) Measurements but Frequent Free Adjustment of Treatment with Cell Phones or E-mails

Bibal Cecile , Laure Castell Anne , Aboumrad Brigitte , Lucchini Philippe , Bougneres Pierre

Background: Many children with type 1 diabetes (T1D) are asked to measure blood glucose (BG) 4–6 times a day routinely to adjust insulin dosages. There is no evidence though that such high frequency is beneficial to HbA1C or glycemic profile, although this is often claimed.Objectives: We challenged ‘the more BG measurements, the better control’ dogma for alleviation of T1D burden in child life and evaluation of HbA1C.<p class="abstext"...

hrp0082p2-d3-485 | Hypoglycaemia | ESPE2014

Nocturnal Hypoglycaemia in Diabetic Children: Continuous Glucose Monitoring Reveals More of the Iceberg

Bachmann Sara , Martin Eva , Ritschard Vreni , Hess Melanie , Jockers Katharina , Vuissoz Jean-Marc , Zumsteg Urs

Background: Hypoglycaemia is the most common and threatening complication in diabetic children. Nocturnal hypoglycaemia is mostly unrecognised and asymptomatic, but recurrent mild hypoglycaemia at night can lead to hypoglycaemia unawareness and reduced performance at daytime.Aims: To evaluate frequency and duration of nocturnal hypoglycaemia in type 1 diabetic children and to identify risk factors for such events.Patients/methods: ...

hrp0082p3-d2-640 | Adrenals &amp; HP Axis (1) | ESPE2014

Therapeutic Troubles of Cushing’s Disease in Adolescence: Report of a Case

Deiana Manuela , Losa Marco , Trettene Adolfo , Scolari Alessandra , Salvatoni Alessandro

Background: Cushing’s disease, due to ACTH-secreting pituitary adenomas, is rare in the pediatric age (0.2–0.5/ million people per year), although accounts for 75–80% of Cushing syndrome in childhood compared to 49–71% in adulthood. We report clinical presentation, diagnostic workup and treatment of a new case with major therapeutics problems.Case report: A 15-year-old girl was referred to our clinic because of secondary amenorrhea, a...

hrp0082p3-d3-943 | Puberty and Neuroendocrinology (1) | ESPE2014

Triptorelin Test in the Diagnosis of Precocious Puberty

Kabour Saida , Fedala Soumeya , Yaker Fetta Amel , Haddam Ali el Mahdi , Rabhi Lila , Chentli Farida , Meskine Djamila

Background: Central precocious puberty (CPP) in girls is characterized by an activation of the hypothalamic–pituitary–ovarian (HPO) axis before 8 years of age. Given the gradual awakening of the GnRH pulse generator, a spectrum of presentations has been found among girls with premature sexual development. CPP are not easily distinguished from idiopathic precocious thelarche (PT) or other intermediate positions along this spectrum. The GnRH test is the gold standard t...

hrp0084p2-284 | Diabetes | ESPE2015

In-Patient Care for Children with Type 1 Diabetes – A Regional Audit in the Yorkshire and Humber Region in the North of England

Uday Suma , Amin Nadia , Campbell Fiona , Yong James

Introduction: An important part of diabetes management is maintaining high standards of in-patient care. A previous audit in the South of England demonstrated difficulties consistently achieving standards identified as good practice.Objectives: To identify variations in in-patient care provided to children with type 1 diabetes across the Yorkshire and Humber region.Methods: The audit was conducted against in-patient care standards ...

hrp0084p2-363 | Fat | ESPE2015

Sleep and Weight Status at 4 Years in the Inma Asturias Cohort

Riano-Galan Isolina , Rodriguez-Dehli Cristina , Fernandez-Somoano Ana , Tardon Adonina

Background: Epidemiologic studies have documented that sleep duration is associated with obesity risk children’s.Objectives: To investigate sleep duration of 4-year-old children (h/day) and to evaluate the association of sleep patterns with weight status at 4 years.Methods: 393 children from the INMA birth cohort of Asturias (Spain). We analysed sleep duration (h/day) during the night and afternoon nap, reported by their paren...

hrp0097p1-520 | Growth and Syndromes | ESPE2023

Does cervical medullary decompression have an impact on growth in children with achondroplasia?

Fava Daniela , Tedesco Caterina , Angelelli Alessia , Napoli Flavia , Pepino Carlotta , Pepe Alessia , Teruzzi Daniela , Pisati Angelica , Fay Cortella Maria , Binelli Maria , Maghnie Mohamad , Di Iorgi Natascia , Elsa Maria Allegri Anna

Background: Foramen magnum stenosis (FMS) is a life-threatening complication in children with achondroplasia (ACH) which may require cervicomedullary decompression (CMD). There is no evidence if FMS and CMD affects growth in children with ACH.Aim: To evaluate the impact of FSM and CMD surgery on anthropometric measurements in children with ACH.Methods: Sixty-five patients with ACH ...