hrp0084p2-568 | Thyroid | ESPE2015

Levothyroxine Replacement in Primary Congenital Hypothyroidism: The Higher the Initial Dose the Higher the Rate of Overtreatment

Tuhan Hale , Abaci Ayhan , Cicek Gizem , Anik Ahmet , Catli Gonul , Demir Korcan , Bober Ece

Background: Congenital hypothyroidism (CH) is the most frequent endocrine disorder during neonatal period and delay in diagnosis and treatment leads to irreversible complications. A high L-thyroxine (LT4) dose is recommended for treatment, while the optimal starting dose is still a matter of debate.Objective and hypotheses: The objective of this study was to determine the effects of various starting doses of LT4 on se...

hrp0094p2-4 | Adrenals and HPA Axis | ESPE2021

Serum Sex Hormone Binding Globulin Levels, But Not 4-Hour Profile of 17-Oh Progesterone, Would Be Useful in Monitoring Children with Congenital Adrenal Hyperplasia

Besci Ozge , Erbas Ibrahim Mert , Kume Tuncay , Acinikli Kubra Yuksek , Abacı Ayhan , Bober Ece , Demir Korcan ,

Background: There exists no gold standard for adjustment of treatment in congenital adrenal hyperplasia. Clinicians try to avoid over-and undertreatment by considering various indicators. We aimed to investigate the sampling times of 17-hydroxyprogesterone (17-OHP) and the use of sex hormone-binding globulin (SHBG) as a monitoring parameter, the association of which was not studied with clinical features. Materials and Methods: This cross-sectional study inclu...

hrp0094p2-353 | Pituitary, neuroendocrinology and puberty | ESPE2021

Clinical course of primary empty sella in children: a 10-year single-center experience

Besci Ozge , Yasar Elif , Mert Erbas Ibrahim , Yuksek Acinikli Kubra , Demir Korcan , Bober Ece , Abacı Ayhan ,

Background: Various studies, mostly conducted in adults, evaluated the hormonal axis in primary empty sella (PES), and reported different forms of pituitary deficiencies. We report our 10-year experience of pediatric cases with PES, investigating the pituitary function, associated impairments, and responses to treatments.Materials and Methods: We reviewed 10,560 cranial and 325 pituitary magnetic resonance imagings (MRIs) performed in ou...

hrp0097p1-193 | Thyroid | ESPE2023

Thyroid hormone resistance syndrome due to a new mutation in the TRHA gene

Tuhan Hale , Donbaloğlu Zeynep , Kırbıyık Özgür , Parlak Mesut , Demir Korcan

Introduction: Resistance to thyroid hormones is defined as lack of response of peripheral tissues to triiodothyronine (T3) which is the active form of thyroid hormones. In general (85%) a mutation is detected in the thyroid hormone receptor β (THRB) gene and more rarely, the thyroid hormone receptor α (TRHA) gene.Case: A 4.7-year-old boy, was admitted to the pediatric endocrinology outpatient clinic of Akdeniz...

hrp0095p1-391 | Thyroid | ESPE2022

Biochemical Indicators of Euthyroid Sick Syndrome in Critically Ill Children

Besci Tolga , Besci Özge , Arslan Gazi , Ilgaz Hande , Prencuva Pınar , Özdemir Göktuğ , Abacı Ayhan , Demir Korcan

Purpose: This study aimed to determine the prevalence and predictors of Euthyroid Sick syndrome (ESS) in pediatric intensive care, and to establish a link between thyroid function tests and mortality.Methods: Between January 2015 and March 2020, children admitted to our pediatric intensive care unit (PICU) and tested for free triiodothyronine (fT3), free thyroxine (fT4), and thyrotropin (TSH) levels were included. Patien...

hrp0092p1-28 | Diabetes and Insulin | ESPE2019

Elevated Anti-tissue Transglutaminase Antibodies in Children Newly Diagnosed with type 1 Diabetes do not Always Indicate Celiac Disease

Paketçi Ahu , Armagan Coskun , Erbas İbrahim Mert , Demir Korcan , Abaci Ayhan , Böber Ece

Introduction: The prevalence of celiac disease is 5–10 times higher in patients with type 1 diabetes mellitus (DM) than in the general population. Therefore, celiac serology should be screened intermittently in type 1 DM patients. However, anti-tissue transglutaminase (anti-TTG) antibody elevation may be detected incidentally at the time of type 1 DM diagnosis and regress spontaneously during follow-up, without medical or dietary interventions.<p clas...

hrp0086p2-p493 | Fat Metabolism and Obesity P2 | ESPE2016

Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents

Tunc Selma , Demir Korcan , Tukun F Ajlan , Topal Cihan , Hazan Filiz , Saglam Burcu , Nalbantoglu Ozlem , Yildiz Melek , Ozkan Behzat

Background: Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity but there is no data for Turkish children.Objective: To determine the prevalence of MC4R mutations in a group of Turkish morbid obese children and adolescents.Method: MC4R gene was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1–18 years) who presented dur...

hrp0082p3-d2-720 | Diabetes (1) | ESPE2014

Anti-Cyclic Citrullinated Peptide Antibodies are not Frequent in Children with Type 1 Diabetes

Yildiz Melek , Isleten Figen , Demir Korcan , Celik Nilufer , Korkmaz Huseyin Anil , Tuglu Birsen , Elmas Ozlem Nalbantoglu , Ozkan Behzat

Background: Type 1 diabetes mellitus is characterized by presence of several organ specific autoantibodies. Anti-cyclic citrullinated peptide (anti-CCP) antibody is a promising marker of rheumatoid arthritis (RA) which is known to coincide with autoimmune diabetes. Presence of these antibodies was not investigated in children with type 1 diabetes.Objective and hypotheses: To evaluate presence of anti-CCP antibodies in children with type 1 diabetes compar...

hrp0084p2-216 | Bone | ESPE2015

A Case with Acrodysostosis and Hormone Resistance

Tunc Selma , Demir Korcan , Hazan Filiz , Kirbiyik Ozgur , Soyaltin Eren , Nalbantoglu Ozlem , Yildiz Melek , Korkmaz Huseyin Anil , Ozkan Behzat

Aim: Acrodysostosis is a rare genetic syndrome characterized by small hands and feet with short, stubby fingers and toes, cone shaped epiphyses, broad nasal root, various abnormalities of mandible, skull, and vertebra, short stature, and mental retardation. Because of the hormone resistance that would accompany, acrodysostosis can be confused with pseudohypoparathyroidism. Mutations of PRKAR1A and PDE4D are reported to be responsible for the disease in less t...

hrp0094p1-64 | Diabetes B | ESPE2021

Initial Neutrophil/Lymphocyte and Lymphocyte/Monocyte Ratios Can Predict Future Insulin Need in Newly Diagnosed Type 1 Diabetes Mellitus

Erbaş Ibrahim Mert , Hajikhanova Aygun , Besci Ozge , Acinikli Kubra Yuksek , Demir Korcan , Bober Ece , Abacı Ayhan ,

Background: The exact mechanism of the partial clinical remission in type 1 diabetes mellitus (T1DM) has not been elucidated yet. The severity of the inflammation at the time of diagnosis may have an impact on the occurrence or duration of this phase.Objective: We aimed to investigate the relationship between hematological inflammatory parameters at the time of diagnosis in children and adolescents with T1DM and the need...